Date published: 2026-10-24

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SENP3 Antibody (G-3) - Immunofluorescence - Image 295352
SENP3 抗体 (G-3): sc-133149. 福尔马林固定的 Hep G2 细胞免疫荧光染色, 显示核定位.
SENP3 抗体 (G-3): sc-133149. 福尔马林固定的 Hep G2 细胞免疫荧光染色, 显示核定位.

SENP3 抗体 (G-3): sc-133149

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寫評論提問
说明书
  • SENP3抗体(G-3)是小鼠单克隆mouse IgG1 κ κ, 在3篇文献中引用，规格为200 µg/ml
  • 针对酸195-389，映射在SENP3的内部区域，human来源
  • 推荐用于 mouse, rat 和 human 来源的SENP3 WB, IP, IF 和 ELISA检测
  • 1 BP-HRP">m-IgG1 BP-HRP是SENP3 Antibody (G-3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与SENP3 Antibody (G-3) 打包提供（请参阅下面的订购信息）。
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関連項目

额外SENP抗体，包括SENP1, SENP3, SENP5, SENP6, SENP7和SENP8

SUMO（small ubiquitin-related modifier，小泛素相关修饰物）是泛素样蛋白家族的一员，可调节多种靶蛋白的多种细胞功能，包括转录、DNA修复、核质转运和染色体分离。SUMO前体蛋白在成熟过程中会被SUMO特异性蛋白酶在"GG"区域后的残基处进行切割。这种前体切割是随后进行SUMO化修饰的先决条件。sentrin特异性（或SUMO特异性）蛋白酶（SENP）蛋白属于肽酶C48家族，包括SENP1-3和SENP5-8。SENP1、SENP2和SENP3可降解UBL1和SMT3H2结合物，随后从SUMO化底物中释放单体。HIPK2是SENP1的一个去SUMO化目标，其在细胞质和细胞核之间穿梭。突变分析表明，SENP1在羧基末端区域含有核输出序列（NES），并且SENP1以NES依赖的方式输出到细胞质。SENP2已被证实为CTNNB1水平的下调因子，因此可能是Wnt通路的调节因子。SUMO蛋白酶SENP3可逆转MEF2的SUMO化，以增强其转录和成肌活性。SENP5定位于核仁，优先处理SUMO-3。它被认为在有丝分裂和/或细胞质分裂中发挥作用。SENP6定位于细胞质并释放SUMO-1。SENP6在生殖器官中的表达较高，表明其可能介导与生殖有关的过程。SENP8参与sentrins的释放。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SENP3 抗体 (G-3) 参考文献:

  1. SENP3缺失可促进M2巨噬细胞极化和乳腺癌进展。  |  Xiao, M., et al. 2022. Mol Oncol. 16: 1026-1044. PMID: 33932085
  2. SUMO蛋白酶SENP3调节由Fis1介导的线粒体自噬。  |  Waters, E., et al. 2022. EMBO Rep. 23: e48754. PMID: 34994490
  3. DNA-PKcs 活性和 DNA 损伤修复需要 SENP3 介导的 TIP60 deSUMOylation。  |  Han, Y., et al. 2022. MedComm (2020). 3: e123. PMID: 35356800
  4. 有丝分裂中的SENP3激活与肿瘤细胞中的cGAS信号传导相结合，从而刺激抗肿瘤免疫。  |  Hu, G., et al. 2022. Cell Death Dis. 13: 640. PMID: 35869062
  5. SENP3促进肿瘤进展，是三阴性乳腺癌的一种新型预后生物标志物。  |  Zhu, Y., et al. 2022. Front Oncol. 12: 972969. PMID: 36698419
  6. SENP3介导的c-Jun去SUMOylation促进了脑缺血和再灌注损伤后小胶质细胞诱导的神经炎症。  |  Xia, Q., et al. 2023. iScience. 26: 106953. PMID: 37332598
  7. 骨髓SENP3缺乏通过调节YAP1的SUMO化，保护小鼠免受饮食和年龄引起的肥胖。  |  Jiang, Y., et al. 2023. Cell Mol Life Sci. 81: 4. PMID: 38070059
  8. SENP3通过调节Wnt10a的表达促进套细胞淋巴瘤的发展。  |  Ma, YN., et al. 2024. Curr Med Sci. 44: 134-143. PMID: 38273178
  9. SENP3通过FSP1的去SUMO化使巨噬细胞对铁死亡敏感。  |  Chen, X., et al. 2024. Redox Biol. 75: 103267. PMID: 39025016
  10. METTL16-SENP3-LTF轴赋予铁死亡抗性并促进肝癌的肿瘤发生。  |  Wang, J., et al. 2024. J Hematol Oncol. 17: 78. PMID: 39218945

订购信息

产品名称产品编号规格价格数量收藏夹

SENP3 抗体 (G-3)

sc-133149
200 µg/ml
CNY2422.00

SENP3 (G-3): m-IgG1 BP-HRP 套装

sc-542640
200 µg Ab; 20 µg BP
CNY2715.00

Hello, Is it possible to get a free sample of antibody ref. Sc-133149? Bests Laurent

Asked by: Laurent
Thank you for your question. We do not offer a sample size.
Answered by: BlakeJ
Date published: 2026-08-13

I am looking for an anti-SENP3 antibody suitable for flow cytometry. I will be using human samples

Asked by: issa
The conjugated primary antibody is recommended and warrantied for flow cytometry (FCM), however we are still gathering data to show on our website. Check back for updates!
Answered by: Technical Support
Date published: 2020-03-09

What is the recommended fixation method for immunofluorescence staining with SENP3 (G-3): sc-133149 monoclonal antibody?

Asked by: Cweed
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24

I was wondering whether i could have a trial sample for the antibody SENP3 Antibody (G-3): sc-133149

Asked by: PARU
Thank you for your question. We do not currently offer a sample size for our mouse monoclonal, SENP3 Antibody (G-3): sc-133149. As an alternative, we do offer a sample size of a different clone to this same protein target, SENP3 Antibody (E-7): sc-137219. Please contact our Technical Service Department for more information and to request a sample. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-01-11
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Rated 5 out of 5 by TinTin from Strong and reliable for IF and WBSpecific and strong Western blot and immunofluorescence data on mouse and human samples. Great choice!
Date published: 2017-01-27
Rated 5 out of 5 by JT from Strong band in WB in human HeLa cellsStrong band in WB in human HeLa cells. -SCBT Publication Review
Date published: 2015-05-16
Rated 5 out of 5 by SM from Published for CoIP in human HeLa cellsPublished for CoIP in human HeLa cells. -SCBT Publication Review
Date published: 2015-04-11
Rated 5 out of 5 by MS from Produced great immunofluorescence nuclearProduced great immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-04-08
Rated 5 out of 5 by SM from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-26
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SENP3 抗体 (G-3) is rated 5.0 out of 5 by 5.
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