Date published: 2025-9-7

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SDHA 抗体 (D-4): sc-166947

4.3(4)
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说明书
  • SDHA抗体(D-4)是小鼠单克隆IgG2a κ, 在18篇文献中引用,规格为200 µg/ml
  • 针对氨基酸461-664的抗原,在SDHA的C-terminus处映射,human来源
  • 推荐用于 mouse, rat 和 human 来源的precursor and mature SDHA WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 SDHA 抗体 (D-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SDHA 抗体 (D-4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

在有氧呼吸反应中,琥珀酸脱氢酶(SDH)催化琥珀酸和泛醌氧化为延胡索酸和泛醇。SDH蛋白复合物由四个亚基组成:一个黄素蛋白亚基(SDHA)、一个铁硫蛋白(SDHB)和两个膜结合亚基(SDHC和SDHD),它们锚定在线粒体内膜上。这些亚基的突变会导致线粒体功能障碍,对应于几种不同的疾病。膜结合组分的突变可能导致遗传性副神经节瘤,而SDHA的突变则与青少年脑病以及Leigh综合征(一种严重的神经系统疾病)相关。SDHB的失活突变与遗传性(但不一定是散发性)嗜铬细胞瘤病例相关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SDHA 抗体 (D-4) 参考文献:

  1. SDHA 的表达缺失可预测胃肠道间质瘤中的 SDHA 突变。  |  Wagner, AJ., et al. 2013. Mod Pathol. 26: 289-94. PMID: 22955521
  2. MiR-31/SDHA 轴通过线粒体代谢调节重编程效率  |  Lee, MR., et al. 2016. Stem Cell Reports. 7: 1-10. PMID: 27346679
  3. SDHA突变的副神经节瘤可能有很高的转移风险。  |  Tufton, N., et al. 2017. Endocr Relat Cancer. 24: L43-L49. PMID: 28500238
  4. Sdha+/-大鼠表现出轻微的肌肉病理变化,但没有明显的行为或生化异常。  |  Siebers, EM., et al. 2018. J Neuropathol Exp Neurol. 77: 665-672. PMID: 29850869
  5. SDHA 功能增益通过 KEAP1-Nrf2 参与炎症线粒体逆行信号传导。  |  Burgener, AV., et al. 2019. Nat Immunol. 20: 1311-1321. PMID: 31527833
  6. Myc介导的SDHA乙酰化引发了基因表达和肿瘤发生的表观遗传调控。  |  Li, ST., et al. 2020. Nat Metab. 2: 256-269. PMID: 32694775
  7. SDHA基因中的一种新发杂合致病变体会导致儿童期发病的双侧视神经萎缩和认知障碍。  |  Zehavi, Y., et al. 2021. Metab Brain Dis. 36: 581-588. PMID: 33471299
  8. 上调SDHA可通过灭活Wnt/β-catenin通路抑制透明细胞肾细胞癌细胞的增殖、迁移和侵袭。  |  Xu, X., et al. 2022. J Recept Signal Transduct Res. 42: 180-188. PMID: 33602019
  9. 含黄素的 SDHA 是口腔癌内在光学特性变化的基础。  |  Marumo, T., et al. 2023. Commun Biol. 6: 1134. PMID: 37945749
  10. SDHA 相关线粒体疾病患者的实验室和基因型关系。  |  Civelek Ürey, B., et al. 2023. Mol Syndromol. 14: 459-460. PMID: 38058758

订购信息

产品名称产品编号规格价格数量收藏夹

SDHA 抗体 (D-4)

sc-166947
200 µg/ml
RMB2377.00

SDHA (D-4): m-IgG Fc BP-HRP 套装

sc-537552
200 µg Ab; 10 µg BP
RMB2662.00

SDHA (D-4): m-IgGκ BP-HRP 套装

sc-534850
200 µg Ab; 40 µg BP
RMB2662.00

SDHA (D-4): m-IgG2a BP-HRP 套装

sc-548052
200 µg Ab; 10 µg BP
RMB2662.00

I am using SDHA (D-4): sc-166947 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Professor Griffin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from WELL BY WBIT WORKED WELL BY WB IN LAB, WILL PURCHASE IT IN THE FUTURE
Date published: 2017-02-20
Rated 4 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of SDHA expression in HeLa whole cell lysate and human heart and rat heart tissue extracts. -SCBT QC
Date published: 2015-04-10
Rated 4 out of 5 by from We have those antibodies as a routine inWe have those antibodies as a routine in our Lab and they work as expected if they are used within a year no more.
Date published: 2015-04-07
Rated 5 out of 5 by from Great immunofluorescence mitochondrial stainingGreat immunofluorescence mitochondrial staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-03-16
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SDHA 抗体 (D-4) is rated 4.3 out of 5 by 4.
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