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SDF-1/CXCL12 抗体 (P-159X): sc-74271

4.5(10)
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说明书
  • SDF-1/CXCL12抗体(P-159X)是小鼠单克隆IgG1 κ, 在27篇文献中引用，规格为50 µg/0.5 ml
  • 免疫human物种的SDF-1的氨基酸20-89
  • 推荐用于 mouse, rat 和 human 来源的SDF-1α and SDF-1β WB, IF 和 IHC(P)检测
  • 目前，我们还没有完成SDF-1/CXCL12 抗体 (P-159X)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

附加SDF抗体，包括SDF-1, SDF-2和SDF-4

C-X-C或α趋化因子家族的特征是一对半胱氨酸残基，它们被单个氨基酸分隔开，并主要作为中性粒细胞的趋化剂。C-X-C家族包括IL-8、NAP-2、MSGA和基质细胞衍生因子-1（SDF-1）。SDF-1最初被描述为前B细胞刺激因子，但现已被证明对T细胞和单核细胞具有强效的趋化作用，但对中性粒细胞无此作用。C-X-C家族的受体是G蛋白偶联的、七次跨膜的域蛋白，包括IL-8RA、IL-8RB和fusin（也被称为LESTR或CXCR-4）。Fusin与IL-8受体具有高度同源性，在氨基酸水平上共享37%的序列同一性。IL-8受体与IL-8、NAP-2和MSGA结合，而fusin与其同源配体SDF-1结合。Fusin已被确定为T嗜性HIV-1的主要共受体，而SDF-1已被证明可以抑制HIV-1感染。由于CXCL12（编码SDF-1的基因）的选择性剪接，存在六种人类SDF-1异构体。已知小鼠和大鼠有三种异构体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SDF-1/CXCL12 抗体 (P-159X) 参考文献:

  1. CXCL12（SDF-1）/CXCR4通路在癌症中的作用。  |  Teicher, BA. and Fricker, SP. 2010. Clin Cancer Res. 16: 2927-31. PMID: 20484021
  2. 在多发性骨髓瘤肿瘤微环境中靶向 SDF-1。  |  Bouyssou, JM., et al. 2016. Cancer Lett. 380: 315-8. PMID: 26655999
  3. 基质细胞衍生因子-1（SDF-1）作为肝脏疾病的治疗靶点。  |  Liepelt, A. and Tacke, F. 2016. Am J Physiol Gastrointest Liver Physiol. 311: G203-9. PMID: 27313175
  4. SDF-1/CXCR4/CXCR7在脑缺血后神经元再生中的作用。  |  Cheng, X., et al. 2017. Front Neurosci. 11: 590. PMID: 29123467
  5. SDF-1调节牙周韧带-间充质干细胞（pdl-MSCs）。  |  Hakki, SS., et al. 2021. J Periodontal Res. 56: 774-781. PMID: 33733508
  6. 间充质干细胞移植过程中SDF-1/CXCR4相互作用的修饰策略。  |  Jiang, Q., et al. 2022. Gen Thorac Cardiovasc Surg. 70: 1-10. PMID: 34510332
  7. SDF-1/CXCR4信号通路在正常发育中的意义。  |  Sadri, F., et al. 2022. Mol Biol Rep. 49: 3307-3320. PMID: 35067815
  8. SDF-1功能化水凝胶微载体用于皮肤瓣修复。  |  Liu, X., et al. 2022. ACS Biomater Sci Eng. 8: 3576-3588. PMID: 35899941
  9. 用Himanthalia elongata提取物靶向SDF-1作为解决皮肤色素沉着问题的有效策略  |  Meunier, M., et al. 2023. J Cosmet Dermatol. 22: 383-394. PMID: 36062379
  10. SDF-1和NOTCH信号在肌源性细胞分化中的作用：miRNA10a、425和5100的作用。  |  Mierzejewski, B., et al. 2023. Stem Cell Res Ther. 14: 204. PMID: 37582765

订购信息

产品名称产品编号规格价格数量收藏夹

SDF-1/CXCL12 抗体 (P-159X)

sc-74271
50 µg/0.5 ml
CNY2422.00

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Tech Service 3
Date published: 2017-02-02
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Rated 3 out of 5 by JoanK from works wellthe product came as a replacement for a lot that didn't work in our hands. It worked well this time with nitrocellulose membrane. It didn't work when we used PVDF membrane. We get 2 bands.
Date published: 2017-11-16
Rated 5 out of 5 by junge12 from well performedThis antibody works well in IHC on human parafin sections.The sections deparafinized, but no antigen retrieval were used.The antibody was used in a 1:200 dilution
Date published: 2017-07-23
Rated 5 out of 5 by anxiang from no background , good qualityLoading 50ug Hela cell lysates, the antibody diluted at 1:600 ,the seconary diluted at 1:5000,both incubated at roo temperature for 2hour.clear band and no background.
Date published: 2017-06-24
Rated 5 out of 5 by zhuoya from Robust signalRobust signal seen in WB in human transfected 293T whole cell lysates.
Date published: 2017-06-01
Rated 5 out of 5 by Berylll from good productSanta antibody samples provide excellent results, Great product! Very clean!
Date published: 2017-02-11
Rated 5 out of 5 by jenni from Highly recommendedVersatile antibody! Cited in multiple publications for use in ELISA, WB, IHC (P) and IF
Date published: 2017-01-05
Rated 5 out of 5 by muzi from Great WBApplied in western blot to detect mouse brain，It shows single and clear ~10 kDa band，Dilution is 1:200.
Date published: 2016-12-17
Rated 4 out of 5 by HF from Produced publishable sandwich ELISA dataProduced publishable sandwich ELISA data with mouse hippocampi were dissected from postnatal mice - SCBT Publication Review
Date published: 2015-03-24
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SDF-1/CXCL12抗体 (P-159X) is rated 4.5 out of 5 by 10.
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