Date published: 2025-9-7
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SCGN Antibody (F-9) - Western Blotting - Image 368688
SCGN 抗体 (F-9): sc-374355. 人胰腺 (A) 和大鼠胰腺 (B) 组织提取物中 SCGN 表达的 Western 印迹分析.
SCGN 抗体 (F-9): sc-374355. 人胰腺 (A) 和大鼠胰腺 (B) 组织提取物中 SCGN 表达的 Western 印迹分析.

SCGN 抗体 (F-9): sc-374355

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说明书
  • SCGN 抗体 F-9 是小鼠单克隆 IgG1 κ，SCGN抗体, 在3篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列186-276位于human物种的SCGN的C-terminus
  • SCGN 抗体 (F-9) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 SCGN
  • 抗SCGN抗体（F-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取SCGN (F-9): sc-374355的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 SCGN 抗体 (F-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与SCGN 抗体 (F-9) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

SCGN抗体（F-9）是一种IgG1 κ型小鼠单克隆SCGN抗体（也称为SCGN抗体），可通过WB、IP、IF、IHC(P)和ELISA技术检测小鼠、大鼠和人类来源的SCGN蛋白。SCGN抗体（F-9）既可以是非偶联的抗SCGN抗体形式，也可以是多种偶联形式的抗SCGN抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。SCGN，也称为Secretagogin、CALBL、setagin或SECRET，是一种由276个氨基酸组成的胞质蛋白，含有六个EF-hand结构域，与钙结合蛋白Calretinin和Calbindin D28K相关。SCGN在胃、甲状腺、结肠、大脑和神经内分泌细胞等多种组织中表达，被认为参与细胞增殖和KCl（氯化钾）介导的钙流事件。通过与KCl的相互作用以及随后调节细胞内钙储存池的能力，SCGN可能起负向控制生长和分化速率的作用，从而间接抑制细胞复制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SCGN 抗体 (F-9) 参考文献:

  1. 一种新型神经内分泌和胰岛朗格汉斯特异性 Ca2+ 结合蛋白 secretagogin 的克隆和表达。  |  Wagner, L., et al. 2000. J Biol Chem. 275: 24740-51. PMID: 10811645
  2. 最近克隆的一种 EF 手 Ca（2+）结合蛋白--secretagogin 在大脑中的表达和血清中的可检测性。  |  Gartner, W., et al. 2001. Cereb Cortex. 11: 1161-9. PMID: 11709487
  3. Secretagogin 是神经内分泌分化的新型标记物。  |  Birkenkamp-Demtröder, K., et al. 2005. Neuroendocrinology. 82: 121-38. PMID: 16449819
  4. 钙离子和 SNAP-25 与六 EF 手蛋白 secretagogin 的结合。  |  Rogstam, A., et al. 2007. Biochem J. 401: 353-63. PMID: 16939418
  5. 泌乳素启动子活性的鉴定和表征。  |  Skovhus, KV., et al. 2006. Scand J Immunol. 64: 639-45. PMID: 17083620
  6. Secretagogin 是人类前列腺中一种新的神经内分泌标记物。  |  Adolf, K., et al. 2007. Prostate. 67: 472-84. PMID: 17285592
  7. 基于大鼠同源物特征的神经内分泌标志物分泌蛋白的新功能。  |  Gartner, W., et al. 2007. Am J Physiol Endocrinol Metab. 293: E347-54. PMID: 17426113
  8. 人脑及其覆盖物肿瘤中分泌蛋白的表达。  |  Pipp, I., et al. 2007. APMIS. 115: 319-26. PMID: 17504298
  9. SCGN 缺乏会导致结肠炎易感性。  |  Sifuentes-Dominguez, LF., et al. 2019. Elife. 8: PMID: 31663849
  10. SCGN调节的阶段性SNARE组装：对突触外排的新见解。  |  Lv, Y., et al. 2020. Neurosci Bull. 36: 1576-1578. PMID: 33025412
  11. SCGN缺乏是自闭症谱系障碍的危险因素。  |  Liu, Z., et al. 2023. Signal Transduct Target Ther. 8: 3. PMID: 36588101
  12. SCGN和STAT3表达与ccRCC的预后相关。  |  Lai, C., et al. 2023. Pathol Res Pract. 252: 154940. PMID: 37977033

订购信息

产品名称产品编号规格价格数量收藏夹

SCGN 抗体 (F-9)

sc-374355
200 µg/ml
RMB2377.00

SCGN (F-9): m-IgG Fc BP-HRP 套装

sc-525955
200 µg Ab; 10 µg BP
RMB2662.00

SCGN 抗体 (F-9) AC

sc-374355 AC
500 µg/ml, 25% agarose
RMB3129.00

SCGN 抗体 (F-9) HRP

sc-374355 HRP
200 µg/ml
RMB2377.00

SCGN 抗体 (F-9) FITC

sc-374355 FITC
200 µg/ml
RMB2482.00

SCGN 抗体 (F-9) PE

sc-374355 PE
200 µg/ml
RMB2580.00

SCGN 抗体 (F-9) Alexa Fluor® 488

sc-374355 AF488
200 µg/ml
RMB2685.00

SCGN 抗体 (F-9) Alexa Fluor® 546

sc-374355 AF546
200 µg/ml
RMB2685.00

SCGN 抗体 (F-9) Alexa Fluor® 594

sc-374355 AF594
200 µg/ml
RMB2685.00

SCGN 抗体 (F-9) Alexa Fluor® 647

sc-374355 AF647
200 µg/ml
RMB2685.00

SCGN 抗体 (F-9) Alexa Fluor® 680

sc-374355 AF680
200 µg/ml
RMB2685.00

SCGN 抗体 (F-9) Alexa Fluor® 790

sc-374355 AF790
200 µg/ml
RMB2685.00

Can SCGN (F-9): sc-374355 monoclonal antibody be used in fish tissues is there any such references regarding the SCGN can you supply a free sample of antibody to test it on fish species.

Asked by: Yashica
Thank you for your question. SCGN Antibody (F-9) is only recommended for detection of SCGN of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. We do not have any data on its compatibility with cell or tissue samples from fish species. Please reach out to our technical service team directly to arrange for a free sample of this antibody.
Answered by: Tech Support Europe
Date published: 2023-01-19

I have a enquiry about secretagogin antibody available in santa cruz [SCGN (F-9): sc-374355]. I want to know if any control scgn peptide is supplied along with the antibody or if that is at all available and we can purchase that seperately.

Asked by: Sumela
Thank you for your question. This SCGN antibody was raised against amino acids 186-276 mapping at the C-terminus of SCGN of human origin. Since it was not raised against a peptide, there is no control peptide for it. I would suggest using a normal mouse IgG as a negative control.
Answered by: Tech Service
Date published: 2020-02-10

Can SCGN (F-9): sc-374355 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, SCGN (F-9): sc-374355 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Great immunoperoxidase cytoplasmic and nuclearGreat immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-02-26
Rated 5 out of 5 by from Satisfactory Western Blot data of SCGN expressionSatisfactory Western Blot data of SCGN expression in non-transfected and mouse SCGN transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-06-27
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SCGN 抗体 (F-9) is rated 5.0 out of 5 by 2.
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