Date published: 2025-9-7
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SATB2 Antibody (SATBA4B10) - Western Blotting - Image 141255
SATB2 抗体 (SATBA4B10): sc-81376. KNRK (A), HT-1080 (B) 和 SH-SY5Y (C) 核提取物中 SATB2 表达的 Western 印迹分析.
SATB2 抗体 (SATBA4B10): sc-81376. KNRK (A), HT-1080 (B) 和 SH-SY5Y (C) 核提取物中 SATB2 表达的 Western 印迹分析.

SATB2 抗体 (SATBA4B10): sc-81376

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说明书
  • SATB2 抗体 SATBA4B10 是小鼠单克隆 IgG1 κ，SATB2抗体, 在67篇文献中引用，规格为100 µg/ml
  • 针对与SATB2的human起源的C-terminal区域相对应的重组蛋白
  • 推荐用于 mouse, rat 和 human 来源的SATB2 WB, IP 和 IF检测
  • 关于如何获取SATB2 (SATBA4B10): sc-81376的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成SATB2 抗体 (SATBA4B10)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外SATB抗体，包括SATB2

SATB2抗体（SATBA4B10）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和免疫荧光（IF）检测小鼠、大鼠和人类来源的SATB2。抗SATB2抗体（SATBA4B10）以非结合形式提供。SATB2（特殊AT富集序列结合蛋白2）在颅面发育中起着至关重要的作用，特别是在颌骨和上颚的形成中，并且是调节骨骼发育和成骨细胞分化的转录网络中不可或缺的一部分。SATB2在成人和胎儿大脑中表现出主要表达，并具有两个CUT DNA结合结构域和一个同源框结构域，这对于基因调节功能至关重要。SATB2与已知的转录抑制因子SATB1关系密切，并与基质附着区（MAR）相互作用，调节包括HoxA2和ATF4（CREB-2）在内的多种基因的转录，而这两种基因对于骨骼发育至关重要。SATB2具有转录激活因子和转录抑制因子的功能，可作为蛋白质支架增强其他DNA结合蛋白的活性。SATB2基因突变可导致腭裂，并常伴有严重的认知障碍，这凸显了其在发育生物学和潜在临床应用中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SATB2 抗体 (SATBA4B10) 参考文献:

  1. 确定 SATB2 为 2q32-q33 上的腭裂基因。  |  FitzPatrick, DR., et al. 2003. Hum Mol Genet. 12: 2491-501. PMID: 12915443
  2. 新型 MAR 结合蛋白 SATB2 的 SUMO 修饰可调节免疫球蛋白 mu 基因的表达。  |  Dobreva, G., et al. 2003. Genes Dev. 17: 3048-61. PMID: 14701874
  3. 新型转录因子Satb2以组织特异性方式与基质附着区DNA元件相互作用，并在发育中的小鼠中枢神经系统中表现出细胞类型依赖性表达。  |  Britanova, O., et al. 2005. Eur J Neurosci. 21: 658-68. PMID: 15733084
  4. 大鼠大脑中以发育和细胞特异性方式表达的新型富含 AT 的 DNA 结合蛋白 SATB2 的分离和特征描述。  |  Szemes, M., et al. 2006. Neurochem Res. 31: 237-46. PMID: 16604441
  5. SATB2 是颅面形态和成骨细胞分化的多功能决定因素。  |  Dobreva, G., et al. 2006. Cell. 125: 971-86. PMID: 16751105
  6. 分析来自三个人群的口腔裂隙病例父母三人中 2 号染色体上的候选基因。  |  Beaty, TH., et al. 2006. Hum Genet. 120: 501-18. PMID: 16953426
  7. Satb2单倍体缺失表型与2q32-q33缺失表型相同，而Satb2缺失则表明Satb2在协调颌骨发育方面起着重要作用。  |  Britanova, O., et al. 2006. Am J Hum Genet. 79: 668-78. PMID: 16960803
  8. 杂合子无义突变 SATB2 与腭裂, 骨质疏松症和认知缺陷有关。  |  Leoyklang, P., et al. 2007. Hum Mutat. 28: 732-8. PMID: 17377962
  9. SATB2在癌症发生中的失调，强调miRNA介导的控制。  |  Chen, QY., et al. 2019. Carcinogenesis. 40: 393-402. PMID: 30916759
  10. SATB2通过增强子重塑来保持结肠干细胞的特性和介导回肠-结肠转换。  |  Gu, W., et al. 2022. Cell Stem Cell. 29: 101-115.e10. PMID: 34582804
  11. SATB2在血液淋巴肿瘤中的表达。  |  Tiu, GC., et al. 2023. J Hematop. 16: 119-122. PMID: 38175442
  12. MTA2-SATB2染色质复合物通过将HNF4A保留在结肠染色质中，抑制结肠向小肠的可塑性。  |  Gu, W., et al. 2024. Nat Commun. 15: 3595. PMID: 38678016

订购信息

产品名称产品编号规格价格数量收藏夹

SATB2 抗体 (SATBA4B10)

sc-81376
100 µg/ml
RMB2504.00

SATB2 (SATBA4B10): m-IgG Fc BP-HRP 套装

sc-551873
100 µg Ab; 10 µg BP
RMB2662.00

Can I use this mouse monoclonal antibody for immunohistochemical staining of mouse tissue?

Asked by: Cweed
This product, sc-81376, is recommended for immunostaining applications. However, it is not readily available directly conjugated to a fluorphore, which we suggest for the staining of mouse tissue. To inquire about directly conjugated primary antibodies, please contact our special orders department for more information.
Answered by: TechService7
Date published: 2016-12-22

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: Cweed
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: TechService7
Date published: 2016-12-22
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Rated 5 out of 5 by from Satb2 antibody reviewVery satisfied. Used with mouse cells. We got very specific nuclear staining in vitro and we also saw very clean specific staining on Western Blot.
Date published: 2019-09-17
Rated 5 out of 5 by from Great antibody both for IHC and western blottingWe used 1:1000 for western blotting and 1:200 for IHC. Both worked very well on mouse brain tissue and sections.
Date published: 2018-07-19
Rated 5 out of 5 by from Excellent staining on mice and rat brain sectionsI tested a sample of this antibody in both mice and rat free-floating brain sections (E17 and P1) and got excellent staining. Signals are stronger with antigen retrieval protocol (citrate buffer, pH 6.0), but are acceptable without antigen retrieval.
Date published: 2018-04-04
Rated 5 out of 5 by from Great antibody!Works great for IF on brain tissue! Dilution is 1:200.
Date published: 2017-02-22
Rated 5 out of 5 by from Great for Western blotSATB2 Antibody (SATBA4B10) produced clear, strong and specific signal by WB
Date published: 2017-01-11
Rated 5 out of 5 by from Strong wbVery clear western blot results; low background !!
Date published: 2016-12-31
Rated 5 out of 5 by from Got correct staining in IF in mouse tissueGot correct staining in IF in mouse tissue.
Date published: 2015-10-05
Rated 5 out of 5 by from WB: positive results in NIH3T3 whole cell lysateWB: positive results in NIH3T3 whole cell lysate. -SCBT QC
Date published: 2015-05-02
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SATB2 抗体 (SATBA4B10) is rated 5.0 out of 5 by 11.
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