Date published: 2025-9-7

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RSAD2 抗体 (G-8): sc-390342

3.5(4)
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说明书
  • RSAD2 抗体 G-8 是小鼠单克隆 IgG3 κ,RSAD2抗体, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的RSAD2的内部区域内的氨基酸126-138之间
  • 推荐用于 mouse, rat 和 human 来源的RSAD2 WB, IP, IF 和 ELISA检测
  • 关于如何获取RSAD2 (G-8): sc-390342免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成RSAD2 抗体 (G-8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

RSAD2抗体(G-8)是一种IgG3κ型小鼠单克隆RSAD2抗体(也称为RSAD2抗体),可通过WB、IP、IF和ELISA等方法检测小鼠、大鼠和人源的RSAD2蛋白。RSAD2抗体(G-8)为非共轭形式的抗RSAD2抗体。RSAD2(含Radical S-腺苷甲硫氨酸结构域的蛋白2),也称为CIG5(巨细胞病毒诱导基因5蛋白)、vig1、viperin或CIG33,是一种由361个氨基酸组成的蛋白质,参与对丙型肝炎病毒、巨细胞病毒和HIV-1等病原体的抗病毒防御。RSAD2定位于内质网的胞质侧,并在病毒感染时重新定位到高尔基体,通过破坏质膜上的脂质筏并支持干扰素诱导的细胞抗病毒状态,从而阻止病毒出芽。此外,RSAD2可以与FDPS(一种对胆固醇以及香叶基化和法尼基化蛋白质的合成至关重要的酶)结合并使其失活,从而在脂质合成中发挥作用。RSAD2的过度表达会导致与动脉粥样硬化相关的异常脂质积累,动脉粥样硬化是一种以动脉硬化为特征的慢性炎症性疾病。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

RSAD2 抗体 (G-8) 参考文献:

  1. Viperin (cig5),一种由人类巨细胞病毒直接诱导的 IFN 诱导型抗病毒蛋白。  |  Chin, KC. and Cresswell, P. 2001. Proc Natl Acad Sci U S A. 98: 15125-30. PMID: 11752458
  2. 抗病毒巨细胞病毒诱导基因 5/viperin 在动脉粥样硬化中表达,并受促炎因子调节。  |  Olofsson, PS., et al. 2005. Arterioscler Thromb Vasc Biol. 25: e113-6. PMID: 15890971
  3. 对慢性丙型肝炎中 ISG 表达的分析发现毒蛇素是一种潜在的抗病毒效应因子。  |  Helbig, KJ., et al. 2005. Hepatology. 42: 702-10. PMID: 16108059
  4. 依赖和不依赖于 Toll 样受体的毒蛇素基因表达以及 PRDI 结合因子-1/BLIMP1 的反调节作用。  |  Severa, M., et al. 2006. J Biol Chem. 281: 26188-95. PMID: 16849320
  5. TLR3配体聚(I:C)诱导星形胶质细胞吲哚胺2,3-二氧化酶:诱导机制及在抗病毒反应中的作用。  |  Suh, HS., et al. 2007. J Virol. 81: 9838-50. PMID: 17626075
  6. 干扰素诱导蛋白蝰蛇蛋白通过扰动脂质筏抑制流感病毒的释放。  |  Wang, X., et al. 2007. Cell Host Microbe. 2: 96-105. PMID: 18005724
  7. 鉴定三种抑制丙型肝炎病毒复制的干扰素诱导细胞酶。  |  Jiang, D., et al. 2008. J Virol. 82: 1665-78. PMID: 18077728
  8. 基于RSAD2(viperin)的自由基-SAM化学,对RSAD2(viperin)广谱抗病毒活性进行统一分析。  |  Honarmand Ebrahimi, K. 2018. Metallomics. 10: 539-552. PMID: 29568838
  9. RSAD2是MDCK细胞中高产疫苗的有效靶标。  |  Qiao, Z., et al. 2022. Viruses. 14: PMID: 36423196
  10. RSAD2在动脉粥样硬化斑块中含量丰富,并促进人平滑肌细胞中干扰素诱导的CXCR3趋化因子。  |  Hayderi, A., et al. 2024. Sci Rep. 14: 8196. PMID: 38589444
  11. RSAD2/viperin在免疫调节、线粒体代谢和自身免疫性疾病中的关键作用。  |  Chen, S., et al. 2024. Inflammation.. PMID: 38909344
  12. HIV诱导的RSAD2/Viperin支持单核细胞衍生巨噬细胞的持续感染。  |  Zankharia, U., et al. 2024. J Virol. 98: e0086324. PMID: 39258908

订购信息

产品名称产品编号规格价格数量收藏夹

RSAD2 抗体 (G-8)

sc-390342
200 µg/ml
RMB2377.00

RSAD2 (G-8) 中和勝肽

sc-390342 P
100 µg/0.5 ml
RMB511.00

是否可用于猪

Asked by: kimbeauty
感谢您的提问。RSAD2 抗体 (G-8): sc-390342 没有在猪的样本上进行过验证,因此不推荐用于猪的样本。 Thank you for your question. RSAD2 antibody (G-8): sc-390342 is not recommended for detection of pig samples.
Answered by: Technical Service SH
Date published: 2025-08-27

What application is the blocking peptide sc-390342 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
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Rated 3 out of 5 by from Ok for WBWestern blot Band of mouse sample is faint but detectable
Date published: 2022-05-01
Rated 1 out of 5 by from Antibody does not workThis antibody recognizes an unknown protein at a similar size as Viperin. Viperin is an interferon-inducible gene whose basal expression is low and is highly upregulated upon IFN treatment. Instead, this antibody recognizes a protein whose expression is consistently high regardless of IFN treatment. I also confirmed my blots using an RSAD2 antibody from a different vendor which demonstrated clear IFN inducibility.
Date published: 2021-12-15
Rated 5 out of 5 by from Excellent RSAD2 antibodyIt works really well, single band, very strong. Samples are liver homogenates from bacteria-infected mice.
Date published: 2021-06-04
Rated 5 out of 5 by from Produced positive Western blot data of RSAD2Produced positive Western blot data of RSAD2 expression in Jurkat and HUV-EC-C whole cell lysates. -SCBT QC
Date published: 2013-05-27
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RSAD2 抗体 (G-8) is rated 3.5 out of 5 by 4.
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