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Rock-2 Antibody (30-J) - Western Blotting - Image 33798
Rock-2 抗体 (30-J): sc-100425. 对 HeLa 全细胞裂解液中 Rock-2 的表达进行 Western 印迹分析.
Rock-2 Antibody (30-J) - Western Blotting - Image 33798
Rock-2 抗体 (30-J): sc-100425. 对 HeLa 全细胞裂解液中 Rock-2 的表达进行 Western 印迹分析.
Rock-2 Antibody (30-J) - Immunofluorescence - Image 35562
Rock-2 抗体 (30-J): sc-100425. 免疫荧光染色多聚甲醛固定的 HeLa 细胞, 显示细胞核和细胞质定位.
Rock-2 抗体 (30-J): sc-100425. 对 HeLa 全细胞裂解液中 Rock-2 的表达进行 Western 印迹分析.

Rock-2 抗体 (30-J): sc-100425

4.7(3)
寫評論提問
说明书
  • Rock-2抗体(30-J)是小鼠单克隆IgG2b κ, 在7篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组Rock-2
  • 推荐用于 mouse, rat 和 human 来源的Rock-2 WB, IP, IF 和 ELISA检测
  • 看 Rock-2 (D-11): sc-398519，可查看有标记的 Rock-2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成Rock-2 抗体 (30-J)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

附加Rock抗体，包括Rock-1和Rock-2

Ras相关的小GTP酶Rho负责调节基于肌动蛋白的细胞骨架结构，包括应力纤维、局部粘附和收缩环装置。Rho蛋白作为分子开关，能够开启和关闭细胞质分裂。尽管对Rho下游的信号传导知之甚少，但已经描述了许多假定的Rho效应蛋白，包括rhophilin、Rhotekin、citron和丝氨酸/苏氨酸激酶、蛋白激酶N。另外还描述了两种Rho激活的丝氨酸/苏氨酸激酶，分别命名为Rock-1和Rock-2（也称为Roka），为含Rho相关卷曲蛋白激酶。Rock-1和Rock-2与肌强直性营养不良激酶在结构上具有相似性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Rock-2 抗体 (30-J) 参考文献:

  1. ROCK-2 与成肌细胞迁移过程中的病灶粘附成熟有关。  |  Goetsch, KP., et al. 2014. J Cell Biochem. 115: 1299-307. PMID: 24700588
  2. ROCK-2选择性靶向及其治疗效果  |  Sharma, P. and Roy, K. 2020. Drug Discov Today. 25: 446-455. PMID: 31837997
  3. CSE 衍生的 H2S 通过抑制 RhoA/ROCK2 通路抑制小鼠脑缺血再灌注损伤后反应性星形胶质细胞的增殖并促进神经功能恢复  |  Zhang, Y., et al. 2021. ACS Chem Neurosci. 12: 2580-2590. PMID: 34252278
  4. 胆固醇瘤患者中的RhoA、ROCK-1和ROCK-2基因表达和多态性。  |  Görür, K., et al. 2021. J Int Adv Otol. 17: 530-535. PMID: 35177391
  5. 贝卢莫司与ROCK-2抑制剂：化学和治疗开发，以获得FDA批准用于治疗慢性移植物抗宿主病。  |  Ali, F. and Ilyas, A. 2022. Curr Res Transl Med. 70: 103343. PMID: 35339032
  6. 在大鼠模型中，H2S 通过促进 ROCK2 在 Tyr722 处的磷酸化保护海马神经元免受缺氧-再氧合损伤。  |  Xue, M., et al. 2022. Molecules. 27: PMID: 35889443
  7. 通过抑制 ROCK2 在 Thr436 和 Ser575 处的磷酸化保护大鼠海马神经元免受缺氧/再氧合损伤的 H2S  |  Fang, F., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37259366
  8. 电针联合药物治疗对脑缺血大鼠纹状体RhoA/ROCK-2信号通路的影响。  |  Liu, M., et al. 2023. Brain Res Bull. 205: 110828. PMID: 38029846
  9. H2S通过抑制海马ROCK2在Thr436和Ser575位点的表达和激活来保护大鼠脑缺血再灌注损伤。  |  Fang, F., et al. 2024. Eur J Pharmacol. 985: 177079. PMID: 39486769
  10. 硫化氢介导的ROCK2抑制对缺血性脑损伤具有血管保护作用。  |  Chen, Y., et al. 2024. Am J Physiol Cell Physiol.. PMID: 39716722

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产品名称产品编号规格价格数量收藏夹

Rock-2 抗体 (30-J)

sc-100425
100 µg/ml
CNY2550.00

Which epitope is recognized by sc-100425 Rock-2 (30-J)?

Asked by: Anonymous
Thank you for your question. Rock-2 Antibody (30-J): sc-100425 has been raised against recombinant Rock-2 of human origin. No epitope mapping has been performed for this antibody yet, so the exact binding region of the antibody is not known. Please contact our Technical Service Department if you have any other questions. Our Asian Technical Service team is available at (+86) 021-60936350 or [email protected] or by live chat on our website.
Answered by: Sen Li
Date published: 2025-08-08

Which epitope is recognized by sc-100425 Rock-2 (30-J)?

Asked by: BG_Trieste
Thank you for your question. Rock-2 Antibody (30-J): sc-100425 has been raised against recombinant Rock-2 of human origin. No epitope mapping has been performed for this antibody yet, so the exact binding region of the antibody is not known.
Answered by: Tech Support Europe
Date published: 2019-06-05

I am using Rock-2 (30-J): sc-100425 for immunofluorescence, what dilution of this antibody should I use?

Asked by: cjMara
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by hongbo1134 from nice quality.We have also used the antibody for IP of endogenous Rock-2 from a primary culture of mouse astrocytes,I got expected signal.It's very nice quality.
Date published: 2017-08-12
Rated 5 out of 5 by TS from Great WB results with HeLa whole cell lysateGreat WB results with HeLa whole cell lysate. -SCBT QC
Date published: 2015-04-27
Rated 4 out of 5 by TO from Produced clear immunofluorescence nuclearProduced clear immunofluorescence nuclear and cytoplasmic staining in paraformaldehyde-fixed HeLa cells. -SCBT QC
Date published: 2015-02-05
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Rock-2 抗体 (30-J) is rated 4.7 out of 5 by 3.
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