Date published: 2025-9-8
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Rev-erbα Antibody (RS-14) - Western Blotting - Image 34280
Rev-erba (RS-14): sc-100910. 对 HeLa 核提取物中 Rev-erba 的表达进行 Western 印迹分析.
Rev-erba (RS-14): sc-100910. 对 HeLa 核提取物中 Rev-erba 的表达进行 Western 印迹分析.

Rev-erbα 抗体 (RS-14): sc-100910

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说明书
  • Rev-erbα抗体(RS-14)是小鼠单克隆IgG1 κ, 在10篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组Rev-erbα
  • 推荐用于 mouse, rat 和 human 来源的Rev-erbα WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取Rev-erbα (RS-14): sc-100910的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Rev-erbα 抗体 (RS-14) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Rev-erbα 抗体 (RS-14) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Rev-erb 抗体包括 Rev-erb α 和 Rev-erb β

Rev-erbα抗体（RS-14）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过应用诸如蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠和人类样本中的Rev-erbα。Rev-erbα抗体（RS-14）以非结合形式提供，可用于多种实验。Rev-erbα是一种孤核受体，通过作为转录抑制剂在调节昼夜节律和代谢过程中发挥着关键作用。Rev-erbα（RS-14）抗体主要识别核中的蛋白质，Rev-erbα与特定的DNA序列结合以调节基因表达。Rev-erbα的核定位使其能够直接影响昼夜节律和能量平衡相关基因的转录，从而影响生理过程，如睡眠-觉醒周期和新陈代谢。Rev-erbα与多种共调控因子相互作用，包括核受体共激活因子5（NCOA5），后者可增强转录活性，进一步凸显其在细胞调节中的重要性。Rev-erbα的多重作用使其成为生物钟学和代谢紊乱研究的重要靶标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Rev-erbα 抗体 (RS-14) 参考文献:

  1. CIA，一种新型雌激素受体辅助激活剂，具有双功能核受体相互作用决定因子。  |  Sauvé, F., et al. 2001. Mol Cell Biol. 21: 343-53. PMID: 11113208
  2. Rev-erbalpha能上调血管平滑肌细胞中的NF-kappaB反应基因。  |  Migita, H., et al. 2004. FEBS Lett. 561: 69-74. PMID: 15013753
  3. 缺乏 rev-erbAalpha 孤儿受体基因的小鼠骨骼肌中肌球蛋白同工酶的异常表达。  |  Pircher, P., et al. 2005. Am J Physiol Regul Integr Comp Physiol. 288: R482-90. PMID: 15374821
  4. 孤儿核受体 Rev-Erb alpha 在脂肪细胞分化和功能中的作用。  |  Laitinen, S., et al. 2005. Biochimie. 87: 21-5. PMID: 15733732
  5. 人类甲状腺激素受体 alpha（c-erbA-1）基因的基因组结构。  |  Laudet, V., et al. 1991. Nucleic Acids Res. 19: 1105-12. PMID: 1850510
  6. REV-ERBα通过调控NF-κB/NLRP3轴整合结肠时钟与实验性结肠炎。  |  Wang, S., et al. 2018. Nat Commun. 9: 4246. PMID: 30315268
  7. 昼夜节律时钟蛋白Rev-erbα可通过小胶质细胞NLRP3炎性体提供神经保护并减轻帕金森病的神经炎症。  |  Kou, L., et al. 2022. J Neuroinflammation. 19: 133. PMID: 35668454
  8. 小胶质细胞REV-ERB&α调节炎症和脂滴的形成，从而驱动雄性小鼠的tauopathy。  |  Lee, J., et al. 2023. Nat Commun. 14: 5197. PMID: 37626048
  9. 抑制REV-ERB&α介导的铁蛋白沉积可减轻2型糖尿病心肌缺血再灌注损伤的易感性。  |  Huang, Q., et al. 2023. Free Radic Biol Med. 209: 135-150. PMID: 37805047
  10. 昼夜节律调节因子 REV-ERB&alpha 的功能反转导致肿瘤基因重编程。  |  Yang, Y., et al. 2024. Proc Natl Acad Sci U S A. 121: e2411321121. PMID: 39383000
  11. 与 Rev-Erb 关系密切的核荷尔蒙受体超家族的新孤儿成员。  |  Dumas, B., et al. 1994. Mol Endocrinol. 8: 996-1005. PMID: 7997240
  12. 孤儿核受体-DNA 复合物的结构要素。  |  Zhao, Q., et al. 1998. Mol Cell. 1: 849-61. PMID: 9660968

订购信息

产品名称产品编号规格价格数量收藏夹

Rev-erbα 抗体 (RS-14)

sc-100910
100 µg/ml
RMB2504.00

Rev-erbα (RS-14): m-IgG Fc BP-HRP 套装

sc-539722
100 µg Ab; 10 µg BP
RMB2662.00

Rev-erbα (RS-14): m-IgG1 BP-HRP 套装

sc-541670
100 µg Ab; 20 µg BP
RMB2662.00

Hello, Do you have this antibody WITHOUT gelatin or BSA? Or do you have AlexaFluor-labeled version?

Asked by: JESH
Thank you for your question. We can offer this antibody without gelatin (there is no BSA) as a special order. Please contact our Special Orders Department to inquire about ordering information. Please call our Technical Service Department, or email <[email protected]>.
Answered by: Technical Support
Date published: 2019-12-11

Hi, can you please tell me what part of the protein the antibody binds to? N-term or C-term? Thank you

Asked by: Andrea Galmozzi
Thank you for your question. This antibody was raised against recombinant Rev-erbα protein spanning amino acids 1-615 (accession#P20393) of human origin. The exact binding epitope has not been mapped. If you have any further questions, please contact Technical Service.
Answered by: Tech Service
Date published: 2019-03-22

I need to use an antibody to detect the protein in samples of canine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 15
Date published: 2017-02-13
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Rated 5 out of 5 by from Great for western blot and IHC-PWe used this antibody at 1:1000 dilution for western blot and IHC-P. We validated the result by using Nr1d1-/- samples.
Date published: 2017-12-01
Rated 5 out of 5 by from Good detectionThis antibody works in WB and provides good signal in staining applications. It is reactive with mouse and human samples and has been used to publish.
Date published: 2017-01-31
Rated 5 out of 5 by from Used this antibody for IF and worked wellUsed this antibody for IF and worked well in staining.
Date published: 2015-08-12
Rated 5 out of 5 by from Performed well in WB in HeLa nuclear extractPerformed well in WB in HeLa nuclear extract. -SCBT QC
Date published: 2015-06-27
Rated 5 out of 5 by from Produced excellent immunoperoxidase nuclearProduced excellent immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human kidney tissue. -SCBT QC
Date published: 2015-03-12
Rated 5 out of 5 by from Positive signal obtained in WB in mouse RevPositive signal obtained in WB in mouse Rev-erb transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-03-06
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Rev-erbα 抗体 (RS-14) is rated 5.0 out of 5 by 6.
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