RETRA CAS: 1036069-26-7
MF: C11H12ClNO3S2
MW: 305.80

RETRA (CAS 1036069-26-7)

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Alternate Names: 2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
Application: CAS: 1036069-26-7, MF: C11H12ClNO3S2, MW: 305.80, Purity: ≥98%
CAS Number: 1036069-26-7
Purity: ≥98%
Molecular Weight: 305.80
Molecular Formula: C11H12ClNO3S2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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This is a mutant p53-dependent activator of p73, an activator of p53-regulated genes, and a suppressor of mutant p53-bearing tumor cells. Greater than 50% of tumors express mutant p53 which is defective for the tumor-suppressor function and contributes to malignancy by blocking a p53 family member p73. Activation of p73 in human cancer produces a cytotoxic effect. RETRA increases the expression level of p73 and releases p73 from the inhibitory complex with mutant 53. This then produces a tumor-supressor effect, in vitro and in vivo.


参考文献

1. Kravchenko, J.E., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 6302-6307. PMID: 18424558

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.71 (Predicted)
IC50 :
tumor cell growth in a mutant p53- and p73-dependent manner: IC50 = 4 µM
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
46861546
MDL Number :
MFCD11114394
SMILES :
C1CSC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O.Cl

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Certificate of Analysis

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