Date published: 2025-9-9

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RecQL1 抗体 (G-2): sc-166446

5.0(1)
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说明书
  • RecQL1抗体(G-2)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫human物种的RecQL1的氨基酸1-110
  • 推荐用于 mouse, rat 和 human 来源的RecQL1 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是RecQL1 Antibody (G-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与RecQL1 Antibody (G-2) 打包提供(请参阅下面的订购信息)。

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    在人类中,RecQ解旋酶家族由WRN、BLM、RecQL1、RecQL4和RecQL5蛋白组成,这些蛋白都含有一个保守的解旋酶结构域。已经证实,WRN和BLM分别是导致Werner综合征和Bloom综合征的致病基因。RecQL1和RecQL5也属于人类RecQ解旋酶家族,但它们与遗传疾病(如果存在)之间的关联尚不清楚。在转化或积极增殖的细胞中,为了保证基因组的稳定性,RecQ解旋酶家族成员的水平会进行差异性上调。编码人类RecQL4的基因位于染色体8q24.3,该基因被认为是导致Rothmund-Thomson综合征(RTS)发展的致病基因。而编码RecQL1和RecQL5的基因则分别位于染色体12p12.1和17q25.1上。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    RecQL1 抗体 (G-2) 参考文献:

    1. RECQL1 DNA 修复螺旋酶:卵巢癌的潜在治疗靶点和增殖标志物。  |  Sanada, S., et al. 2013. PLoS One. 8: e72820. PMID: 23951333
    2. 人类 RECQL1 参与端粒维护。  |  Popuri, V., et al. 2014. Nucleic Acids Res. 42: 5671-88. PMID: 24623817
    3. RECQL1 和 WRN DNA 修复螺旋酶:癌症的潜在治疗靶点和增殖标志物。  |  Futami, K. and Furuichi, Y. 2014. Front Genet. 5: 441. PMID: 25620975
    4. RECQL 基因突变与乳腺癌易感性有关。  |  Sun, J., et al. 2015. PLoS Genet. 11: e1005228. PMID: 25945795
    5. 乳腺癌基因种系突变的临床意义:RECQL.  |  Bowden, AR. and Tischkowitz, M. 2019. Breast Cancer Res Treat. 174: 553-560. PMID: 30610487
    6. RECQL 螺旋酶可在复制压力下防止复制叉崩溃。  |  Benedict, B., et al. 2020. Life Sci Alliance. 3: PMID: 32820027
    7. RECON 综合征是一种由 DNA 螺旋酶 RECQL1 突变引起的基因组不稳定疾病。  |  Abu-Libdeh, B., et al. 2022. J Clin Invest. 132: PMID: 35025765
    8. WRN RECQL螺旋酶的非酶促功能可调节拓扑异构酶-I-DNA共价复合物的清除,并触发癌症中的NF-κB信号传导。  |  Gupta, P., et al. 2022. Aging Cell. 21: e13625. PMID: 35582959
    9. ER阳性乳腺肿瘤中RECQL蛋白的高表达与较好的生存率有关。  |  Mahmoodi, A., et al. 2022. Front Oncol. 12: 877617. PMID: 35712517
    10. RECQL 螺旋酶缺陷型乳腺癌的免疫浸润、侵袭性病理和不良生存结果。  |  Lashen, A., et al. 2024. Neoplasia. 47: 100957. PMID: 38134458

    订购信息

    产品名称产品编号规格价格数量收藏夹

    RecQL1 抗体 (G-2)

    sc-166446
    200 µg/ml
    RMB2377.00

    RecQL1 (G-2): m-IgG Fc BP-HRP 套装

    sc-537491
    200 µg Ab; 10 µg BP
    RMB2662.00

    RecQL1 (G-2): m-IgGκ BP-HRP 套装

    sc-534770
    200 µg Ab; 40 µg BP
    RMB2662.00

    RecQL1 (G-2): m-IgG1 BP-HRP 套装

    sc-545203
    200 µg Ab; 20 µg BP
    RMB2662.00

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with RecQL1 (G-2): sc-166446?

    Asked by: Cweed
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Good Western Blot data of RecQL1 expression in nonGood Western Blot data of RecQL1 expression in non-transfected and mouse RecQL1 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-03-05
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    RecQL1 抗体 (G-2) is rated 5.0 out of 5 by 1.
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