Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

RBM9 抗体 (D-10): sc-365386

5.0(2)
寫評論提問

说明书
  • RBM9抗体(D-10)是小鼠单克隆IgM (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的RBM9的N-terminus附近的氨基酸22-47之间
  • 推荐用于 mouse, rat 和 human 来源的RBM9 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine and bovine
  • 目前,我们还没有完成RBM9 抗体 (D-10)的首选二抗检测试剂的鉴定。这项工作正在进行中。

    快捷链接

    関連項目

    RBM9(RNA结合基序蛋白9),也称为RTA、fxh、FOX2、Fox-2、HNRBP2或HRNBP2,是一种含有单个RRM(RNA识别基序)结构域的390个氨基酸的蛋白质。RBM9被认为是神经系统和其他细胞类型中替代外显子剪接的关键调节因子。RBM9调节高度保守的RNA 5'-UGCAUGU-3'元件的剪接活性,这是一种内含子剪接增强子,通常位于组织特异性替代外显子附近。RBM9阻止U2AF65(U2 snRNP辅助因子大亚基)与RNA剪接元件的3'剪接位点结合,这会影响组织特异性外显子的替代剪接。RBM9还与ERa(雌激素受体α)转录因子相互作用,并调节ERa的转录活性。由于替代剪接事件的存在,RBM9有八种同工型。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    RBM9 抗体 (D-10) 参考文献:

    1. RGS9-2的克隆和特征:RGS9基因的纹状体丰富替代剪接产物。  |  Rahman, Z., et al. 1999. J Neurosci. 19: 2016-26. PMID: 10066255
    2. RGS9-Gbeta 5L 与感光细胞膜上的蛋白锚特异性结合,大大提高了其催化活性。  |  Lishko, PV., et al. 2002. J Biol Chem. 277: 24376-81. PMID: 12006596
    3. RGS9 在阿片剂作用中的重要作用  |  Zachariou, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 13656-61. PMID: 14595021
    4. R9AP 基因敲除小鼠感光器中缺少 RGS9.Gbeta5 GTPase 激活复合物。  |  Keresztes, G., et al. 2004. J Biol Chem. 279: 1581-4. PMID: 14625292
    5. 脑特异性 RGS9-2 通过其独特的富脯氨酸结构域定位到细胞核。  |  Bouhamdan, M., et al. 2004. Biochim Biophys Acta. 1691: 141-50. PMID: 15110994
    6. RGS9-2 可调节大鼠纹状体胆碱能中间神经元中 D2 多巴胺受体介导的 Ca2+ 通道抑制。  |  Cabrera-Vera, TM., et al. 2004. Proc Natl Acad Sci U S A. 101: 16339-44. PMID: 15534226
    7. D2 多巴胺受体通过 RGS9 DEP 结构域与 G 蛋白信号转导调节器 9-2(RGS9-2)共定位,RGS9 基因敲除小鼠会出现与多巴胺通路相关的运动障碍。  |  Kovoor, A., et al. 2005. J Neurosci. 25: 2157-65. PMID: 15728856
    8. 缺乏 RGS9 的小鼠运动协调能力不足。  |  Blundell, J., et al. 2008. Brain Res. 1190: 78-85. PMID: 18073128
    9. RGS9:大鼠和小鼠纹状体中特异表达的 G 蛋白信号调节器。  |  Thomas, EA., et al. 1998. J Neurosci Res. 52: 118-24. PMID: 9556034
    10. 视锥中 RGS9 的高表达水平,RGS9 是视杆细胞中最主要的 GTPase 加速蛋白。  |  Cowan, CW., et al. 1998. Proc Natl Acad Sci U S A. 95: 5351-6. PMID: 9560279

    订购信息

    产品名称产品编号规格价格数量收藏夹

    RBM9 抗体 (D-10)

    sc-365386
    200 µg/ml
    RMB2377.00

    RBM9 (D-10) 中和勝肽

    sc-365386 P
    100 µg/0.5 ml
    RMB511.00

    Does this RBM9 antibody recognise all isoformes? In other words what is the sequence it recognises, is this present in all isoforms? Regards 

    Asked by: Helena88
    Thank you for your question. Our RBM9 antibody sc-365386 is specific for an epitope mapping between amino acids 22-47 near the N-terminus of RBM9 of human origin (accession # O43251). This sequence is conserved in all known isoforms currently, so it should detect all isoforms.
    Answered by: Technical Service
    Date published: 2017-03-31

    What application is the blocking peptide sc-365386 P appropriate for?

    Asked by: jerojero
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
    • y_2025, m_8, d_31, h_8CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_2
    • loc_zh_CN, sid_365386, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 102ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Produced exceptional immunofluorescence nuclearProduced exceptional immunofluorescence nuclear and cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-02-07
    Rated 5 out of 5 by from Good Western Blot data of RBM9 expressionGood Western Blot data of RBM9 expression in NIH/3T3 whole cell lysate. -SCBT QC
    Date published: 2013-04-27
    • y_2025, m_8, d_31, h_8
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_365386, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 16ms
    • REVIEWS, PRODUCT
    RBM9抗体 (D-10) is rated 5.0 out of 5 by 2.
    • y_2025, m_8, d_31, h_8
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_365386, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 100ms
    • REVIEWS, PRODUCT