Date published: 2025-9-7

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Rad23B 抗体 (H-8): sc-137088

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说明书
  • Rad23B 抗体 H-8 是小鼠单克隆 IgG1 (kappa轻链),Rad23B抗体,规格为200 µg/ml
  • 针对氨基酸77-196的图谱,在Rad23B的内部区域,mouse起源
  • Rad23B 抗体 (H-8) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Rad23B
  • 抗Rad23B抗体(H-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Rad23B (H-8): sc-137088免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Rad23B Antibody (H-8) for WB applications. 的首选辅助检测试剂,这些试剂现与Rad23B Antibody (H-8) 打包提供(请参阅下面的订购信息)。

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関連項目

Rad23B抗体(H-8)是一种IgG1 κ小鼠单克隆Rad23B抗体(也称为Rad23B抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Rad23B蛋白。Rad23B抗体(H-8)既可以是非偶联的抗Rad23B抗体形式,也可以是多种偶联形式的抗Rad23B抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。哺乳动物细胞表达两种Rad23(基因组修复蛋白)同源物:Rad23A(也称为HR23A)和Rad23B(也称为HR23B)。在典型细胞中,小鼠Rad23B的含量约为小鼠Rad23A的十倍。位于野生型小鼠胚胎成纤维细胞中的内源性XPC(着色性干皮病C蛋白)相对稳定;其稳态水平和稳定性似乎因小鼠Rad23B基因的靶向中断而显著降低,但小鼠Rad23A基因的中断并不会导致这种降低。小鼠Rad23双基因的缺失会导致XPC蛋白水平进一步强烈降低。RAD23基因(RAD23A和RAD23B)编码人类Rad23蛋白,对于紫外线损伤DNA的切除修复至关重要。RAD23基因与其他DNA修复基因RAD2、RAD6、RAD7、RAD18和RAD54相似,这些基因也都在响应DNA损伤和减数分裂期间表现出转录增加。Rad23是一种核蛋白,含有一个生物功能所需的泛素样结构域。这种高度保守的蛋白质参与核苷酸切除修复(NER),并通过其N端与蛋白酶体相关联。Rad23的C端泛素相关结构域从酵母到人类都是进化上保守的。Rad23还可以作为26S蛋白酶体活性的调节因子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Rad23B 抗体 (H-8) 参考文献:

  1. rhp23 是人类 HHR23A 和酿酒酵母 RAD23 核苷酸切除修复基因的同源物,它参与了细胞周期控制和蛋白质泛素化。  |  Elder, RT., et al. 2002. Nucleic Acids Res. 30: 581-91. PMID: 11788722
  2. 通过损伤诱导和 RAD23 依赖性稳定色素沉着病 C 组蛋白来调节 DNA 修复的新机制。  |  Ng, JM., et al. 2003. Genes Dev. 17: 1630-45. PMID: 12815074
  3. DNA 修复蛋白 hHR23a 的泛素识别。  |  Wang, Q., et al. 2003. Biochemistry. 42: 13529-35. PMID: 14621999
  4. hHR23A 的 XPC 结合域结构揭示了蛋白质相互作用的疏水斑块。  |  Kamionka, M. and Feigon, J. 2004. Protein Sci. 13: 2370-7. PMID: 15322280
  5. 两种哺乳动物 Rad23 同源物的相对水平决定了色素性角化病 C 组蛋白复合物的组成和稳定性。  |  Okuda, Y., et al. 2004. DNA Repair (Amst). 3: 1285-95. PMID: 15336624
  6. UBA2 结构域起着内在稳定信号的作用,可保护 Rad23 免受蛋白酶体降解。  |  Heessen, S., et al. 2005. Mol Cell. 18: 225-35. PMID: 15837425
  7. 人类 DNA 修复蛋白 hHR23B 的 XPC 结合域的溶液结构和骨架动力学。  |  Kim, B., et al. 2005. FEBS J. 272: 2467-76. PMID: 15885096
  8. HHR23A是酿酒酵母Rad23的人类同源物,它能调节色素沉着病C蛋白,是核苷酸切除修复所必需的。  |  Hsieh, HC., et al. 2005. Biochem Biophys Res Commun. 335: 181-7. PMID: 16105547
  9. 人类 DNA 修复因子 hHR23A 和 hHR23B 发挥不同功能的证据。  |  Chen, L. and Madura, K. 2006. FEBS Lett. 580: 3401-8. PMID: 16712842
  10. XPC-RAD23B和TFIIH在核苷酸切除修复中损伤识别和验证的分子基础。  |  Mu, H., et al. 2018. DNA Repair (Amst). 71: 33-42. PMID: 30174301
  11. 细胞质 RAD23B 与 CORO1C 相互作用,协同促进结直肠癌的进展和转移。  |  Li, J., et al. 2021. Cancer Lett. 516: 13-27. PMID: 34062216
  12. 通过 miR-142-3p/MAP4K3 轴敲除 circ-RAD23B 可抑制非小细胞肺癌的进展。  |  Zhuang, Q., et al. 2022. Thorac Cancer. 13: 750-760. PMID: 35106926

订购信息

产品名称产品编号规格价格数量收藏夹

Rad23B 抗体 (H-8)

sc-137088
200 µg/ml
RMB2377.00

Rad23B (H-8): m-IgG Fc BP-HRP 套装

sc-527120
200 µg Ab; 10 µg BP
RMB2662.00

Rad23B (H-8): m-IgG1 BP-HRP 套装

sc-532493
200 µg Ab; 20 µg BP
RMB2662.00

Rad23B 抗体 (H-8) AC

sc-137088 AC
500 µg/ml, 25% agarose
RMB3129.00

Rad23B 抗体 (H-8) HRP

sc-137088 HRP
200 µg/ml
RMB2377.00

Rad23B 抗体 (H-8) FITC

sc-137088 FITC
200 µg/ml
RMB2482.00

Rad23B 抗体 (H-8) PE

sc-137088 PE
200 µg/ml
RMB2580.00

Rad23B 抗体 (H-8) Alexa Fluor® 488

sc-137088 AF488
200 µg/ml
RMB2685.00

Rad23B 抗体 (H-8) Alexa Fluor® 546

sc-137088 AF546
200 µg/ml
RMB2685.00

Rad23B 抗体 (H-8) Alexa Fluor® 594

sc-137088 AF594
200 µg/ml
RMB2685.00

Rad23B 抗体 (H-8) Alexa Fluor® 647

sc-137088 AF647
200 µg/ml
RMB2685.00

Rad23B 抗体 (H-8) Alexa Fluor® 680

sc-137088 AF680
200 µg/ml
RMB2685.00

Rad23B 抗体 (H-8) Alexa Fluor® 790

sc-137088 AF790
200 µg/ml
RMB2685.00

Are there any issues with using sc-137088: Rad23B (H-8) mouse monoclonal primary antibody on mouse samples?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-137088 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Quality of AntibodyI bought this antibody as a sample to test. The antibody is of good quality.
Date published: 2018-07-31
Rated 4 out of 5 by from Potent and very specific antibodyThis monoclonal antibody was independently tested in-house by Kinexus Bioinformatics Corporation and validated for use for Western blotting. There was medium detection of the ~55 kDa target protein in a HeLa/Jurkat cell lysate mix, but not detected in mouse tissues (brain/testes/thymus/muscle mix). No major cross-reactivities were observed at 2 µg/ml antibody concentration with off-target proteins in the mouse tissues tested or in the HeLa/Jurkat cell lysate mix.
Date published: 2016-11-10
Rated 5 out of 5 by from Worked with transfected lysate by WBWorked with transfected lysate by WB -SCBT QC
Date published: 2013-11-13
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Rad23B 抗体 (H-8) is rated 4.7 out of 5 by 3.
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