Date published: 2025-9-7
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PTH/PTHrP-R Antibody (3D1.1) - Western Blotting - Image 355477
PTH/PTHrP-R 抗体 (3D1. 1): sc-12722. MCF7 (A), HeLa (B) 和 F9 (C) 全细胞裂解液中 PTH/PTHrP-R 表达的 Western 印迹分析.
PTH/PTHrP-R 抗体 (3D1. 1): sc-12722. MCF7 (A), HeLa (B) 和 F9 (C) 全细胞裂解液中 PTH/PTHrP-R 表达的 Western 印迹分析.

PTH/PTHrP-R 抗体 (3D1.1): sc-12722

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说明书
  • PTH/PTHrP-R 抗体 3D1.1 是小鼠单克隆 IgG1 κ，PTH/PTHrP-R抗体, 在43篇文献中引用，规格为200 µg/ml
  • 表位定位到PTH/PTHrP-R的155-169氨基酸，该氨基酸来自human
  • PTH/PTHrP-R 抗体 (3D1.1) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 PTH/PTHrP-R type I
  • 抗PTH/PTHrP-R抗体（3D1.1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还可偶联TRITC 用于IF, IHC(P) 和FCM
  • 关于如何获取PTH/PTHrP-R (3D1.1): sc-12722的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 PTH/PTHrP-R 抗体 (3D1.1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PTH/PTHrP-R 抗体 (3D1.1) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

Parathyroid Hormone Receptor 抗体

PTH/PTHrP-R抗体（3D1.1）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测小鼠、大鼠和人类来源的PTH/PTHrP-R蛋白。PTH/PTHrP-R 单克隆抗体（3D1.1）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种 Alexa Fluor® 结合物。甲状旁腺激素（PTH）受体，也称为PTH/PTHrP-R，通过调节PTH和甲状旁腺激素相关肽（PTHrP）的作用，在钙稳态和骨代谢中起着至关重要的作用。PTH/PTHrP-R主要位于骨骼和肾脏目标细胞的表面，在那里PTH/PTHrP-R促进PTH和PTHrP的作用，导致肾脏钙的重吸收增加和骨吸收增强。PTH/PTHrP-R的正常运作对于维持血液中的钙水平至关重要，而PTH/PTHrP-R的失调会导致甲状旁腺功能亢进或骨质疏松等疾病。编码PTH/PTHrP-R的基因位于人类染色体3p21.31上，PTH/PTHrP-R的表达受钙水平和其他激素信号的严格调控，这凸显了PTH/PTHrP-R在内分泌信号通路中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PTH/PTHrP-R 抗体 (3D1.1) 参考文献:

  1. 信号转导在甲状旁腺激素（PTH）G 蛋白偶联受体和 PTH 相关蛋白内化过程中的作用  |  Huang, Z., et al. 1999. Endocrinology. 140: 1294-300. PMID: 10067856
  2. PTH 和 PTHrP 的受体：其生物学重要性和功能特性。  |  Mannstadt, M., et al. 1999. Am J Physiol. 277: F665-75. PMID: 10564229
  3. 甲状旁腺激素（PTH）/PTH 相关蛋白（PTHrP）的 G 蛋白偶联受体激活介导的细胞凋亡。  |  Turner, PR., et al. 2000. Mol Endocrinol. 14: 241-54. PMID: 10674397
  4. 1 型甲状旁腺激素/甲状旁腺激素相关肽受体在 MC3T3-E1 细胞中的核定位：与血清诱导的细胞增殖有关。  |  Watson, PH., et al. 2000. Bone. 26: 221-5. PMID: 10709993
  5. 牛卵巢中 PTHrP 和 PTHR（PTH/PTHrP-r）mRNA 和多肽的表达以及卵母细胞成熟过程中 PTHrP 处理后对牛囊胚体外发育的刺激。  |  Watson, PH., et al. 2001. Anat Embryol (Berl). 203: 175-84. PMID: 11303903
  6. 甲状旁腺激素相关蛋白（PTHrP）和PTH/PTHrP-受体（PTH/PTHrP-R）在胃肠道间质瘤（GIST）, 子宫肌瘤和裂殖瘤中的表达。  |  Yoshizaki, A., et al. 2004. Scand J Gastroenterol. 39: 133-7. PMID: 15000274
  7. 甲状旁腺激素受体配体特立帕肽、阿帕帕肽和长效 PTH 对细胞内信号通路的初始参与具有可比性。  |  Sato, T., et al. 2021. JBMR Plus. 5: e10441. PMID: 33977197
  8. 通过对吡啶并[2,3-d][1]苯并氮杂卓-6-酮衍生物的先导优化，发现了一种强效、选择性和口服型人类甲状旁腺激素受体 1 (hPTHR1) 拮抗剂 (DS69910557)。  |  Arai, Y., et al. 2022. Bioorg Med Chem. 64: 116763. PMID: 35487102
  9. 甲状旁腺激素相关蛋白（PTHrP）和甲状旁腺激素受体-1（PTH1R）在颞下颌关节髁状软骨中的表达受咬合升高的影响。  |  Zhuang, Q., et al. 2023. J Dent Sci. 18: 626-635. PMID: 37021209
  10. 甲状旁腺激素相关肽及其受体信使核糖核酸在人类羊膜和绒毛膜蜕膜中的表达：对分泌和功能的影响。  |  Bruns, ME., et al. 1995. Am J Obstet Gynecol. 173: 739-46. PMID: 7573236
  11. 乳腺癌中甲状旁腺激素相关蛋白及其受体的共表达：一种潜在的自分泌效应系统。  |  Iezzoni, JC., et al. 1998. Mod Pathol. 11: 265-70. PMID: 9521473
  12. 人类 PTH/PTHrP 受体的双重信号和配体选择性。  |  Takasu, H., et al. 1999. J Bone Miner Res. 14: 11-20. PMID: 9893061

订购信息

产品名称产品编号规格价格数量收藏夹

PTH/PTHrP-R 抗体 (3D1.1)

sc-12722
200 µg/ml
RMB2377.00

PTH/PTHrP-R (3D1.1): m-IgG Fc BP-HRP 套装

sc-526533
200 µg Ab; 10 µg BP
RMB2662.00

PTH/PTHrP-R (3D1.1): m-IgG1 BP-HRP 套装

sc-531906
200 µg Ab; 20 µg BP
RMB2662.00

PTH/PTHrP-R 抗体 (3D1.1) AC

sc-12722 AC
500 µg/ml, 25% agarose
RMB3129.00

PTH/PTHrP-R 抗体 (3D1.1) HRP

sc-12722 HRP
200 µg/ml
RMB2377.00

PTH/PTHrP-R 抗体 (3D1.1) FITC

sc-12722 FITC
200 µg/ml
RMB2482.00

PTH/PTHrP-R 抗体 (3D1.1) PE

sc-12722 PE
200 µg/ml
RMB2580.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 488

sc-12722 AF488
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 546

sc-12722 AF546
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 594

sc-12722 AF594
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 647

sc-12722 AF647
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 680

sc-12722 AF680
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) Alexa Fluor® 790

sc-12722 AF790
200 µg/ml
RMB2685.00

PTH/PTHrP-R 抗体 (3D1.1) TRITC

sc-12722 TRITC
200 µg/ml
RMB2407.00

What is the recommended antigen retrieval method for IHC-P with the sc-12722 antibody? Thanks

Asked by: Paula Lemos
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2023-01-25

I am a Phd student in NUI Galway. We are to purchase Anti-PTH/PTHrP-R Antibody (3D1.1) sc-12722. I was wondering if it already comes in dissolved form or in powdered form? If it does come in dissolved form, how much quantity is provided per vial? Thanks

Asked by: Vatsal
Thank you for your question. As indicated in the product datasheet, this antibody is supplied as 200 µg in 1 ml of PBS with 0.1 % gelatin and <0.1 % sodium azide.
Answered by: Tech Support Europe
Date published: 2021-09-13

I would like to use sc-12722 for some double staining. Any tips for using only mouse monoclonal antibodies?

Asked by: Cweed
We recommend using directly conjugated primary antibodies. This product, sc-12722, is available directly conjugated to FITC, AF488, and AF647.
Answered by: Technical Support 15
Date published: 2017-01-25
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Rated 4 out of 5 by from 做组化不错哦做过细胞组化荧光，都不错，但是我的WB结果出的不太好，求大神指导，总体很好用，因为这个分子其他抗体试了不少了
Date published: 2019-11-01
Rated 4 out of 5 by from It's fine.PTH/PTHrP-R(3D1.1) expression in human urine(1:200 in 5%non-fat milk).
Date published: 2017-09-18
Rated 4 out of 5 by from Great resultI used this product for western blot. It works good in Breast cancer cell lines.
Date published: 2017-06-01
Rated 5 out of 5 by from Excellent antibodyThe (3D1.1) clone is an excellent antibody with clean and specific results in WB and IHC(P). Very popular antibody with over a dozen product citations!
Date published: 2017-01-12
Rated 4 out of 5 by from Data published in: Cafforio PData published in: Cafforio P, Savonarola A, Stucci S, De Matteo M, Tucci M, Brunetti AE, Vecchio VM, Silvestris F. PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression. J Bone Miner Res. 2014;29(1):55-66. doi: 10.1002/jbmr.2022.
Date published: 2015-10-27
Rated 4 out of 5 by from Publishable data in IP using human HEK293 cellsPublishable data in IP using human HEK293 cells -SCBT Publication Review
Date published: 2015-07-18
Rated 5 out of 5 by from Great band detected in WB using SaosGreat band detected in WB using Saos-2 whole cell lysate. -SCBT QC
Date published: 2015-03-31
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-03-18
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PTH/PTHrP-R 抗体 (3D1.1) is rated 4.3 out of 5 by 12.
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