Date published: 2025-9-9

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PNP 抗体 (H-7): sc-365081

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说明书
  • PNP抗体(H-7)是小鼠单克隆IgG2b κ, 在2篇文献中引用,规格为200 µg/ml
  • 针对human起源的PNP内部区域内的氨基酸95-150进行
  • 推荐用于 mouse, rat 和 human 来源的PNP WB, IP, IF 和 ELISA检测
  • 2b BP-HRP">m-IgG2b BP-HRPm-IgGκ BP-HRP是PNP Antibody (H-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与PNP Antibody (H-7) 打包提供(请参阅下面的订购信息)。

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関連項目

嘌呤核苷磷酸化酶(PNP),也称为肌苷磷酸化酶,形成同源三聚体。它属于PNP/MTAP磷酸化酶蛋白家族。人PNP催化核糖核苷和2′-脱氧核糖核苷的可逆磷酸解,对鸟嘌呤、次黄嘌呤及其类似物具有特异性。PNP缺陷是一种罕见的常染色体隐性遗传病,与儿童T淋巴细胞功能和神经障碍的严重缺陷有关,占联合免疫缺陷病例的4%。PNP缺陷儿童极易感染、患自身免疫性疾病、神经功能障碍和癌症。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PNP 抗体 (H-7) 参考文献:

  1. 人类PNP与鸟嘌呤的晶体结构。  |  de Azevedo, WF., et al. 2003. Biochem Biophys Res Commun. 312: 767-72. PMID: 14680831
  2. PNP抗癌基因治疗。  |  Zhang, Y., et al. 2005. Curr Top Med Chem. 5: 1259-74. PMID: 16305530
  3. 新型嘌呤核苷类似物治疗T细胞系急性淋巴细胞白血病和淋巴瘤。  |  Ravandi, F. and Gandhi, V. 2006. Expert Opin Investig Drugs. 15: 1601-13. PMID: 17107284
  4. 不含色氨酸的人类PNP揭示了催化位点的相互作用。  |  Ghanem, M., et al. 2008. Biochemistry. 47: 3202-15. PMID: 18269249
  5. 通过19F-NMR和晶体学分析人类PNP的催化位点构象。  |  Suarez, J., et al. 2013. Chem Biol. 20: 212-22. PMID: 23438750
  6. 使用PNP和HYNIC核制备99mTc标记的卟啉复合物的制备和评估:研究核选择对小鼠模型药代动力学和肿瘤摄取的影响。  |  Guleria, M., et al. 2019. Medchemcomm. 10: 606-615. PMID: 31057740
  7. 基于聚乳酸纤维增强聚乳酸(PLGA)的Trachyspermum Ammi Seed Essential Oil(TSEO-PNP)纳米胶囊作为一种安全, 天然, 高效的抗癌化合物在人HT-29结肠癌细胞系中的应用。  |  Almnhawy, M., et al. 2021. Nutr Cancer. 73: 2808-2820. PMID: 33319599
  8. 莲蓬多糖的结构特征、抗氧化和抗炎活性。  |  Zheng, Q., et al. 2022. Int J Biol Macromol. 212: 111-122. PMID: 35594937
  9. 肌磷脂屏障破坏、机械超敏反应和缺claudin-12的多发性神经病疼痛。  |  Chen, JT., et al. 2023. Neurobiol Dis. 185: 106246. PMID: 37527762
  10. 人类诱导多能干细胞/胚胎干细胞衍生的锥体神经元前体在大鼠脊髓损伤模型中显示出安全性和有效性。  |  Li, M., et al. 2024. Cell Mol Life Sci. 81: 318. PMID: 39073571

订购信息

产品名称产品编号规格价格数量收藏夹

PNP 抗体 (H-7)

sc-365081
200 µg/ml
RMB2377.00

PNP (H-7): m-IgGκ BP-HRP 套装

sc-535148
200 µg Ab; 40 µg BP
RMB2662.00

PNP (H-7): m-IgG2b BP-HRP 套装

sc-549345
200 µg Ab; 10 µg BP
RMB2662.00

What is the recommended fixation method for immunofluorescence staining with PNP (H-7): sc-365081 monoclonal antibody?

Asked by: Trav11
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Produced exceptional immunofluorescence cytoplasmicProduced exceptional immunofluorescence cytoplasmic and nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-03-15
Rated 5 out of 5 by from Great Western Blot data of PNP expression in IGreat Western Blot data of PNP expression in I-11. -SCBT QC
Date published: 2014-01-16
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PNP 抗体 (H-7) is rated 5.0 out of 5 by 2.
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