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PKA IIβ reg Antibody (C-2) - Western Blotting - Image 358564
PKA IIβ reg 抗体 (C-2): sc-376778. NIH/3T3 (A) 和 Neuro-2A (B) 全细胞裂解液中 PKA IIβ reg 表达的 Western 印迹分析.
PKA IIβ reg Antibody (C-2) - Western Blotting - Image 358564
PKA IIβ reg 抗体 (C-2): sc-376778. NIH/3T3 (A) 和 Neuro-2A (B) 全细胞裂解液中 PKA IIβ reg 表达的 Western 印迹分析.
PKA IIβ reg Antibody (C-2) - Western Blotting - Image 159014
PKA IIβ reg (C-2): sc-376778. 未转染: sc-110760 (A) 和转染人 PKA IIβ reg: sc-129479 (B) 293 全细胞裂解液中 PKA IIβ reg 表达的 Western 印迹分析.
PKA IIβ reg 抗体 (C-2): sc-376778. NIH/3T3 (A) 和 Neuro-2A (B) 全细胞裂解液中 PKA IIβ reg 表达的 Western 印迹分析.

PKA IIβ reg 抗体 (C-2): sc-376778

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说明书
  • PKA II beta reg 抗体 C-2 是小鼠单克隆 IgG3 κ，PKA IIβ reg抗体, 在14篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列21-110位于human物种的PKA IIβ regulatory chain的N-terminus附近
  • 推荐用于 mouse, rat 和 human 来源的PKA IIβ reg WB, IP, IF 和 ELISA检测
  • 关于如何获取PKA IIβ reg (C-2): sc-376778的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP是PKA IIβ reg Antibody (C-2) 适用于 WB 应用。 的首选辅助检测试剂，该试剂现与PKA IIβ reg Antibody (C-2) 搭配使用（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

附加PKA抗体，包括PKA Phosphopeptide Substrate, PKA I α reg, PKA I β reg, PKA II α reg, PKA II β reg, PKA α cat, PKA β cat和PKA γ cat

PKA IIβ reg抗体（C-2）是一种IgG3 κ小鼠单克隆PKA II beta reg抗体（也称为PKA IIβ reg抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的PKA II beta reg蛋白质。PKA IIβ reg抗体（C-2）以非偶联的抗PKA II beta reg抗体形式提供。第二信使环磷酸腺苷（cAMP）通过激活cAMP依赖性蛋白激酶（cAPK或PKA）介导细胞对外部信号的各种反应，如增殖、离子转运、代谢调节和基因转录。当cAMP与四聚体PKA全酶的两个调节亚基结合时，PKA被激活，导致活性催化亚基的释放。已经鉴定出三种催化（C）亚基，分别命名为Cα、Cβ和Cγ，每种都代表特定的基因产物。Cα和Cβ密切相关（93%的氨基酸序列相似性），而Cγ与Cα和Cβ的相似性分别为83%和79%。cAMP水平升高时，转录的激活是由PKA转位到细胞核中引起的，在细胞核中，PKA在丝氨酸133上磷酸化转录因子cAMP反应元件结合蛋白（CREB），进而导致TFIIB与TATA盒结合蛋白TBP1结合，从而将磷酸化CREB与Pol II转录起始复合物连接起来。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PKA IIβ reg 抗体 (C-2) 参考文献:

  1. 人类睾丸组织特异性蛋白激酶（C gamma）的分子克隆--代表 cAMP 依赖性蛋白激酶催化亚基的第三种同工型。  |  Beebe, SJ., et al. 1990. Mol Endocrinol. 4: 465-75. PMID: 2342480
  2. 环磷酸腺苷可通过 CREB 在丝氨酸 133 处的磷酸化刺激体生长抑素基因的转录。  |  Gonzalez, GA. and Montminy, MR. 1989. Cell. 59: 675-80. PMID: 2573431
  3. 编码人 cAMP 依赖性蛋白激酶催化亚基 C alpha 的 cDNA 克隆。  |  Maldonado, F. and Hanks, SK. 1988. Nucleic Acids Res. 16: 8189-90. PMID: 2843813
  4. 多巴胺在学习过程中对 PKA 的异步调节具有细胞类型特异性  |  Lee, SJ., et al. 2021. Nature. 590: 451-456. PMID: 33361810
  5. PKA 分隔将 cAMP 信号转导和自噬联系起来。  |  Grisan, F., et al. 2021. Cell Death Differ. 28: 2436-2449. PMID: 33742135
  6. PKA/ PKG 抑制剂在血小板研究中的潜力和局限性。  |  Shpakova, V., et al. 2022. Platelets. 33: 859-868. PMID: 34845961
  7. STK25 通过磷酸化 PRKAR1A 来抑制 PKA 信号传导。  |  Zhang, X., et al. 2022. Cell Rep. 40: 111203. PMID: 35977512
  8. 运动通过多巴胺和腺苷激活纹状体神经元中的 PKA。  |  Ma, L., et al. 2022. Nature. 611: 762-768. PMID: 36352228
  9. 通过 cAMP/PKA 和 cGMP/PKG 促进蛋白稳态。  |  Ahammed, MS. and Wang, X. 2024. Trends Mol Med.. PMID: 39477759
  10. 生理浓度的环磷酸腺苷对蛋白激酶的激活作用。  |  Beavo, JA., et al. 1974. Proc Natl Acad Sci U S A. 71: 3580-3. PMID: 4372627
  11. 通过 cAMP 依赖性蛋白激酶进行信号转导。  |  Meinkoth, JL., et al. 1993. Mol Cell Biochem. 127-128: 179-86. PMID: 7935349
  12. 酶的磷酸化-磷酸化。  |  Krebs, EG. and Beavo, JA. 1979. Annu Rev Biochem. 48: 923-59. PMID: 38740

订购信息

产品名称产品编号规格价格数量收藏夹

PKA IIβ reg 抗体 (C-2)

sc-376778
200 µg/ml
RMB2377.00

PKA IIβ reg (C-2): m-IgG3 BP-HRP 套装

sc-550587
200 µg Ab; 40 µg BP
RMB2662.00

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-376778: PKA IIβ reg (C-2) mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 4 out of 5 by from PKA IIbeta Anticorpo C-2Ho comprato questo anticorpo qualche mese fa. E' stato utilizzato sia in Western blotting che i immunofluorescenza e sono molto soddisfatta.
Date published: 2018-06-11
Rated 4 out of 5 by from Great antibody for Western BlotThis antibody has been used in Western Blot to detect PKA RIIb in rat skeletal muscle samples, showing only one band at ~50 kDa. Antibody dilution 1:1000.
Date published: 2017-11-09
Rated 4 out of 5 by from Good qualityThis antibody been used detect human brain tissue sample by western blot at dilution 1:400,I got specific band at 53kd.
Date published: 2016-12-21
Rated 5 out of 5 by from Potent and very specific antibodyThis monoclonal antibody was independently tested in-house by Kinexus Bioinformatics Corporation and validated for use for Western blotting. There was strong detection of the ~64 kDa target protein in mouse tissues (brain/testes/thymus/muscle mix). No major cross-reactivities were observed at 2 µg/ml antibody concentration with off-target proteins in the mouse tissues tested.
Date published: 2016-11-10
Rated 5 out of 5 by from Nice Western blot data of PKA II reg expressionNice Western blot data of PKA II reg expression in non-transfected and human PKA II reg transfected 293 whole cell lysates. -SCBT QC
Date published: 2013-07-19
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PKA IIβ reg 抗体 (C-2) is rated 4.4 out of 5 by 5.
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