Pimaricin, Streptomyces chattanoogensis CAS: 7681-93-8
MF: C33H47NO13
MW: 665.7
An antifungal polyene macrolide.

Pimaricin, Streptomyces chattanoogensis (CAS 7681-93-8)

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Alternate Names: Natamycin
Application: Pimaricin, Streptomyces chattanoogensis is an antifungal polyene macrolide
CAS Number: 7681-93-8
Purity: >98%
Molecular Weight: 665.7
Molecular Formula: C33H47NO13
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Investigations show that the compound predominantly binds to the main sterol in fungal and yeast membranes, ergosterol. Ergosterol is a building block of yeasts and molds, which is responsible for intracellular nutrient transport, and therefore vital for their survival. As ergosterol is not present in the outer membranes of bacteria, these remain unaffected.
Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE.


参考文献

1. Weisblum, B. 1984. Br. Med. Bull. 40: 47-53. PMID: 6442874
2. Pedersen, J.C. 1992. Appl. Environ. Microbiol. 58: 1064-1066. PMID: 16348667
3. Mendes, M.V., et al. 2007. Chem. Biol. 14: 279-290. PMID: 17379143
4. Kells, P.M., et al. 2010. Chem. Biol. 17: 841-851. PMID: 20797613
5. Santos-Aberturas, J., et al. 2010. J Biol Chem. [Epub ahead of print]. PMID: 21187288

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in Acetic acid (5 mg/ml), 0.1%HCOOH in Methanol (1 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), DMSO (7 mg/ml), and methanol (~1 mg/ml).
Storage :
Store at 4° C
Melting Point :
280° C
Boiling Point :
952.17° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D +265.8°, c = 0.6 in Acetic Acid
pK Values :
pKa: 3.71 (Predicted), pKb: 8.12 (Predicted)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
RTECS :
TK3325000
PubChem CID :
6473973
Merck Index :
14: 6427
MDL Number :
MFCD00135085
EC Number :
231-683-5

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