Pimaricin, Streptomyces chattanoogensis CAS: 7681-93-8
MF: C33H47NO13
MW: 665.7
An antifungal polyene macrolide.

Pimaricin, Streptomyces chattanoogensis (CAS 7681-93-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: Natamycin
Application: Pimaricin, Streptomyces chattanoogensis is an antifungal polyene macrolide
CAS Number: 7681-93-8
Purity: >98%
Molecular Weight: 665.7
Molecular Formula: C33H47NO13
* 参考分析证明 大量特定数据 (包括水 含量).

Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Investigations show that the compound predominantly binds to the main sterol in fungal and yeast membranes, ergosterol. Ergosterol is a building block of yeasts and molds, which is responsible for intracellular nutrient transport, and therefore vital for their survival. As ergosterol is not present in the outer membranes of bacteria, these remain unaffected.
Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE.


1. Weisblum, B. 1984. Br. Med. Bull. 40: 47-53. PMID: 6442874
2. Pedersen, J.C. 1992. Appl. Environ. Microbiol. 58: 1064-1066. PMID: 16348667
3. Mendes, M.V., et al. 2007. Chem. Biol. 14: 279-290. PMID: 17379143
4. Kells, P.M., et al. 2010. Chem. Biol. 17: 841-851. PMID: 20797613
5. Santos-Aberturas, J., et al. 2010. J Biol Chem. [Epub ahead of print]. PMID: 21187288

Appearance :
Physical State :
Solubility :
Soluble in Acetic acid (5 mg/ml), 0.1%HCOOH in Methanol (1 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), DMSO (7 mg/ml), and methanol (~1 mg/ml).
Storage :
Store at 4° C
Melting Point :
280° C
Boiling Point :
952.17° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D +265.8°, c = 0.6 in Acetic Acid
pK Values :
pKa: 3.71 (Predicted), pKb: 8.12 (Predicted)
WGK Germany :
PubChem CID :
Merck Index :
14: 6427
MDL Number :
EC Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 107ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 19ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎致电我们的免费电话 800-820–8626.
版权© 2007-2020圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。