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Pim-1 抗体 (G-11): sc-374116

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说明书
  • Pim-1 抗体 G-11 是小鼠单克隆 IgG2a κ,Pim-1抗体, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Pim-1的N-terminus的氨基酸90-115之间
  • Pim-1 抗体 (G-11) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Pim-1; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • Pim-1 抗体 (G-11) 可偶联 琼脂糖 用于 IP; 还可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是Pim-1 Antibody (G-11) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Pim-1 Antibody (G-11) 打包提供(请参阅下面的订购信息)。
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関連項目

Pim-1抗体(G-11)是一种IgG2a κ小鼠单克隆Pim-1抗体(也称为PIM1抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Pim-1蛋白。Pim-1抗体(G-11)既可以是非偶联的抗Pim-1抗体形式,也可以是多种偶联形式的抗Pim-1抗体,包括琼脂糖、PE、FITC和多种Alexa Fluor®偶联物。Pim-1是一种丝氨酸/苏氨酸激酶,在淋巴细胞转化过程中与c-Myc协同作用。在细胞周期从G1早期到G1晚期的进程中,pim-1的表达增加,在G1/S边界和G2期保持高水平。Pim-1在转录和翻译水平上都受到调控,并且已被证明可由IL-2刺激诱导。Pim-1还在T细胞分化中发挥作用,并且已被证明可刺激c-Myc介导的caspase-3样蛋白酶上游的凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Pim-1 抗体 (G-11) 参考文献:

  1. Pim-1激酶通过促进心脏保护信号抑制病理损伤。  |  Fischer, KM., et al. 2011. J Mol Cell Cardiol. 51: 554-8. PMID: 21255581
  2. Pim-1激酶调节动力学相关蛋白1介导七氟烷后条件诱导的心脏保护作用  |  Liu, JD., et al. 2017. Chin Med J (Engl). 130: 309-317. PMID: 28139514
  3. PIM-1 mRNA表达是急性髓细胞性白血病的潜在预后生物标志物。  |  Cheng, H., et al. 2017. J Transl Med. 15: 179. PMID: 28851457
  4. Pim-1激酶磷酸化心脏肌钙蛋白I并调节心脏肌丝功能。  |  Zhu, N., et al. 2018. Cell Physiol Biochem. 45: 2174-2186. PMID: 29544221
  5. 大鼠视网膜中的Pim-1表达及其在视神经挤压后的变化。  |  Zhang, S., et al. 2018. Anat Rec (Hoboken). 301: 1968-1976. PMID: 30299595
  6. Pim-1 通过增强视神经损伤后视网膜神经节细胞的再生能力来保护视网膜神经节细胞  |  Zhang, S., et al. 2020. Exp Neurobiol. 29: 249-272. PMID: 32624507
  7. 关于PIM-1蛋白活性位点和功能的系统综述。  |  Zhao, Y., et al. 2022. Hum Cell. 35: 427-440. PMID: 35000143
  8. 通过药效团模型、基于分子对接的虚拟筛选和生物学评估鉴定Pim-1激酶抑制剂。  |  Huang, J., et al. 2022. Curr Comput Aided Drug Des. 18: 240-246. PMID: 35490326
  9. 作为新型Pim-1激酶抑制剂的大环苯并[b]吡啶并[4,3-e][1,4]恶嗪衍生物的设计、合成和生物活性评估。  |  Xu, J., et al. 2022. Bioorg Med Chem Lett. 72: 128874. PMID: 35779826
  10. Pim-1在人类癌症中的临床意义:与预后和临床病理特征相关的荟萃分析。  |  Lai, L., et al. 2022. Cancer Control. 29: 10732748221106268. PMID: 35844176

订购信息

产品名称产品编号规格价格数量收藏夹

Pim-1 抗体 (G-11)

sc-374116
200 µg/ml
CNY2422.00

Pim-1 (G-11): m-IgG Fc BP-HRP 套装

sc-529665
200 µg Ab; 10 µg BP
CNY2715.00

Pim-1 (G-11): m-IgGκ BP-HRP 套装

sc-522628
200 µg Ab, 40 µg BP
CNY2715.00

Pim-1 (G-11): m-IgG2a BP-HRP 套装

sc-547356
200 µg Ab; 10 µg BP
CNY2715.00

Pim-1 抗体 (G-11) AC

sc-374116 AC
500 µg/ml, 25% agarose
CNY3189.00

Pim-1 抗体 (G-11) FITC

sc-374116 FITC
200 µg/ml
CNY2527.00

Pim-1 抗体 (G-11) PE

sc-374116 PE
200 µg/ml
CNY2625.00

Pim-1 抗体 (G-11) Alexa Fluor® 488

sc-374116 AF488
200 µg/ml
CNY2738.00

Pim-1 抗体 (G-11) Alexa Fluor® 546

sc-374116 AF546
200 µg/ml
CNY2738.00

Pim-1 抗体 (G-11) Alexa Fluor® 594

sc-374116 AF594
200 µg/ml
CNY2738.00

Pim-1 抗体 (G-11) Alexa Fluor® 647

sc-374116 AF647
200 µg/ml
CNY2738.00

Pim-1 抗体 (G-11) Alexa Fluor® 680

sc-374116 AF680
200 µg/ml
CNY2738.00

Pim-1 抗体 (G-11) Alexa Fluor® 790

sc-374116 AF790
200 µg/ml
CNY2738.00

Pim-1 (G-11) 中和勝肽

sc-374116 P
100 µg/0.5 ml
CNY519.00

Can this be used for flow cytometry? If so, is it surface or ICS?

Asked by: E R D
Thank you for your question. Pim-1 Antibody (G-11) is available conjugated to phycoerythrin or FITC as well as various AlexaFluor dyes for flow cytometry. The antibody is specific for an epitope mapping between amino acids 2-27 at the N-terminus of Pim-1 of human origin.
Answered by: Technical Support Europe
Date published: 2020-10-23

What application is the blocking peptide sc-374116 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
  • y_2026, m_10, d_23, h_6CST
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Rated 5 out of 5 by Sunny Lee from Great productThis antibody works well for western blot. dilution 1:500.
Date published: 2017-05-31
Rated 5 out of 5 by 小新贝贝 from wonderful antibody!WB of rat protein with a dilution of 1:500,the band is clear and special!
Date published: 2017-05-21
Rated 5 out of 5 by JM from Produced nice Western blot data of PimProduced nice Western blot data of Pim-1 expression in mouse spleen tissue extract and K-562 whole cell lysate . -SCBT QC
Date published: 2014-11-03
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Pim-1 抗体 (G-11) is rated 5.0 out of 5 by 3.
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