Date published: 2025-9-8
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PICK1 Antibody (A-8) - Western Blotting - Image 93745
PICK1 抗体 (A-8): sc-166591. 非转染: sc-117752 (A) 和小鼠 PICK1 转染: sc-122567 (B) 293T 全细胞裂解液中 PICK1 表达的 Western 印迹分析.
PICK1 抗体 (A-8): sc-166591. 非转染: sc-117752 (A) 和小鼠 PICK1 转染: sc-122567 (B) 293T 全细胞裂解液中 PICK1 表达的 Western 印迹分析.

PICK1 抗体 (A-8): sc-166591

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说明书
  • PICK1抗体(A-8)是小鼠单克隆IgG2a (kappa轻链)，规格为200 µg/ml
  • 针对氨基酸1-300的抗原，在PICK1的N-terminus处映射，human来源
  • 推荐用于 mouse, rat 和 human 来源的PICK1 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是PICK1 Antibody (A-8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与PICK1 Antibody (A-8) 打包提供（请参阅下面的订购信息）。

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    基因信息
    说明书与实验方案
    研究信息

    関連項目

    与C激酶1相互作用的蛋白质（PICK1）是一种含有PDZ结构域的蛋白质，它位于核周区域，并在响应PKCα激活时被磷酸化。PKCα对于调节多种细胞类型的增殖和分化至关重要，其催化区域内含有一个PDZ结合域，这是其他PKC亚型所没有的。PICK1的PDZ结构域发生突变会抑制PICK1与PKCα的结合。此外，PICK1还与α-氨基-3-羟基-5-甲基-异噁唑-4-丙酸（AMPA）受体的羧基末端相互作用，这是一种位于兴奋性突触的神经递质受体。这表明PICK1通过靶向和锚定AMPA到特定突触，在突触传递的调制中发挥作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PICK1 抗体 (A-8) 参考文献:

    1. 钙与PICK1的结合对于AMPA受体的细胞内保留至关重要，而AMPA受体是长期抑制的基础。  |  Citri, A., et al. 2010. J Neurosci. 30: 16437-52. PMID: 21147983
    2. BAR结构域蛋白PICK1控制肾上腺色细胞中囊泡的数量和大小。  |  Pinheiro, PS., et al. 2014. J Neurosci. 34: 10688-700. PMID: 25100601
    3. Syntabulin调节神经元中含PICK1的囊泡的运输。  |  Xu, J., et al. 2016. Sci Rep. 6: 20924. PMID: 26868290
    4. PICK1 PDZ 结构域与钙调素 B 的结合可调控破骨细胞的分化。  |  Kamano, Y., et al. 2018. Biochem Biophys Res Commun. 496: 83-88. PMID: 29305867
    5. PICK1缺乏会加剧败血症相关的急性肺损伤，并通过减少xCT来损害谷胱甘肽的合成。  |  Qian, M., et al. 2018. Free Radic Biol Med. 118: 23-34. PMID: 29471107
    6. PICK1抑制帕金（Parkin）的E3泛素连接酶活性，并降低其神经保护作用。  |  He, J., et al. 2018. Proc Natl Acad Sci U S A. 115: E7193-E7201. PMID: 29987020
    7. 小胶质细胞上的PICK1/TLR4复合物参与调节LPS诱导的败血症相关性脑病。  |  Wang, L., et al. 2021. Int Immunopharmacol. 100: 108116. PMID: 34500285
    8. 适配蛋白PICK1靶向分拣受体SorLA。  |  Binkle, L., et al. 2022. Mol Brain. 15: 18. PMID: 35183222
    9. 通过全原子模拟研究PICK1 PDZ结构域对不同配体的变构反应。  |  Stevens, AO., et al. 2022. Protein Sci. 31: e4474. PMID: 36251217
    10. PICK1通过调节铁稳态来调节缺氧内皮细胞的糖酵解和血管生成。  |  Cao, Y., et al. 2024. Mol Cell Biochem. 479: 1297-1312. PMID: 37368155

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PICK1 抗体 (A-8)

    sc-166591
    200 µg/ml
    		RMB2377.00

    PICK1 (A-8): m-IgG Fc BP-HRP 套装

    sc-537509
    200 µg Ab; 10 µg BP
    		RMB2662.00

    PICK1 (A-8): m-IgGκ BP-HRP 套装

    sc-534792
    200 µg Ab; 40 µg BP
    		RMB2662.00

    PICK1 (A-8): m-IgG2a BP-HRP 套装

    sc-548036
    200 µg Ab; 10 µg BP
    		RMB2662.00

    I need to use an antibody to detect the protein in samples of porcine origin. Do you know if PICK1 (A-8): sc-166591 mouse monoclonal antibody will work?

    Asked by: jerojero
    Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 4 out of 5 by from good features!After the SDS-PAGE electrophoresis of protein extracted from rat hippocampus, the brand of PICK1 was clearly visible. PICK1 played an important role in the experiment.
    Date published: 2016-12-03
    Rated 5 out of 5 by from Great Western blot data of PICK1 expression in nonGreat Western blot data of PICK1 expression in non-transfected and mouse PICK1 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-11-17
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    PICK1 抗体 (A-8) is rated 4.5 out of 5 by 2.
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