Date published: 2025-9-6

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PIASy 抗体 (H-9): sc-376315

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说明书
  • PIASy抗体(H-9)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列61-130位于mouse物种的PIASy的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的PIASy WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是PIASy Antibody (H-9) for WB applications. 的首选辅助检测试剂,这些试剂现与PIASy Antibody (H-9) 打包提供(请参阅下面的订购信息)。

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    関連項目

    白细胞介素-6(IL-6)型细胞因子家族,包括IL-6和许多类似的细胞因子和生长因子,在调节基因激活、增殖和分化方面发挥重要作用。STAT家族的转录因子参与IL-6家族介导的信号转导通路,激活后经历磷酸化、二聚化和核转位。细胞对细胞因子的反应持续时间和强度可以通过几种调节机制的作用来调整。一个例子涉及激活的信号转导物和转录激活物(STAT)家族(PIAS家族)的蛋白质抑制剂,它们在细胞因子信号传导中作为STATs的负调节因子。PIAS蛋白也能够共激活类固醇受体依赖性转录。人PIASy是雄激素受体(AR)的510个氨基酸转录共抑制因子。此外,PIASy可能调节p53介导的事件,并可能将p53导向不依赖反式激活的凋亡模式。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PIASy 抗体 (H-9) 参考文献:

    1. PIASy抑制Smad转录活性,是活化STAT的抑制剂。  |  Long, J., et al. 2003. Proc Natl Acad Sci U S A. 100: 9791-6. PMID: 12904571
    2. PIASy介导NEMO的sumoylation和NF-kappaB的激活,以应对基因毒性应激。  |  Mabb, AM., et al. 2006. Nat Cell Biol. 8: 986-93. PMID: 16906147
    3. PIASy 控制 Ets-1 的泛素依赖性蛋白酶体降解。  |  Nishida, T., et al. 2007. Biochem J. 405: 481-8. PMID: 17456046
    4. PIASy通过将C/EBPdelta隔离到核外围来抑制CCAAT/增强子结合蛋白delta(C/EBPdelta)的转录活性。  |  Zhou, S., et al. 2008. J Biol Chem. 283: 20137-48. PMID: 18477566
    5. PIASy 通过竞争 SRC-1 的结合抑制 LRH-1 依赖性 CYP11A1 的表达。  |  Hsieh, HT., et al. 2009. Biochem J. 419: 201-9. PMID: 19067654
    6. PIASy 可刺激 HIF1α SUMOylation,并在缺氧情况下负向调节 HIF1α 的活性。  |  Kang, X., et al. 2010. Oncogene. 29: 5568-78. PMID: 20661221
    7. 活化 STAT Y 蛋白抑制因子(PIASy)通过与 LIM 同源域转录因子 Isl1 相互作用调节胰岛素分泌  |  Yan, C., et al. 2016. Sci Rep. 6: 39308. PMID: 28000708
    8. 在E3连接酶PIASy中鉴定出一种新的小泛素样修饰(SUMO)相互作用基序。  |  Kaur, K., et al. 2017. J Biol Chem. 292: 10230-10238. PMID: 28455449
    9. SUMO E3连接酶PIASy介导高糖诱导的大鼠肾小球系膜细胞NF-κB炎症信号的激活。  |  Huang, W., et al. 2017. Mediators Inflamm. 2017: 1685194. PMID: 29038616
    10. 酒精诱导的通过PIASy上调的细胞自噬促进人类肝癌细胞中HCV的复制。  |  Ran, M., et al. 2018. Cell Death Dis. 9: 898. PMID: 30185779

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PIASy 抗体 (H-9)

    sc-376315
    200 µg/ml
    RMB2377.00

    PIASy (H-9): m-IgG Fc BP-HRP 套装

    sc-540545
    200 µg Ab; 10 µg BP
    RMB2662.00

    PIASy (H-9): m-IgG1 BP-HRP 套装

    sc-542196
    200 µg Ab; 20 µg BP
    RMB2662.00

    I need to use an antibody to detect the protein in samples of porcine origin. Do you know if PIASy (H-9): sc-376315 mouse monoclonal antibody will work?

    Asked by: DefinitelyNotMatt
    Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced positive Western blot data of PIASyProduced positive Western blot data of PIASy expression in non-transfected and human PIASy transfected 293T whole cell lysates. -SCBT QC
    Date published: 2013-01-14
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    PIASy 抗体 (H-9) is rated 5.0 out of 5 by 1.
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