Date published: 2025-9-6
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Per1 Antibody (E-8) - Immunohistochemistry - Image 370266
Per1 抗体 (E-8): sc-398890. 对福尔马林固定, 石蜡包埋的人食管组织进行免疫过氧化物酶染色, 显示鳞状上皮细胞的细胞核和细胞质染色.
Per1 抗体 (E-8): sc-398890. 对福尔马林固定, 石蜡包埋的人食管组织进行免疫过氧化物酶染色, 显示鳞状上皮细胞的细胞核和细胞质染色.

Per1 抗体 (E-8): sc-398890

4.2(10)
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说明书
  • Per1 抗体 E-8 是小鼠单克隆 IgM κ，Per1抗体, 在8篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的Per1的N-terminus附近的氨基酸17-43之间
  • 推荐用于 mouse, rat 和 human 来源的Per1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-398890 X, 200 µg/0.1 ml)
  • 关于如何获取Per1 (E-8): sc-398890的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP 是 Per1 抗体 (E-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Per1 抗体 (E-8) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品，请参阅我们的小鼠 IgG 结合蛋白完整列表。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Per 抗体 包括 Per1, Per2和Per3

Per1抗体（E-8）是一种IgM κ小鼠单克隆Per1抗体（也称为RIGUI抗体、Period Circadian Protein Homolog 1抗体、Circadian Clock Protein PERIOD 1抗体、Period Circadian Clock 1抗体、HPER1抗体、PER抗体、Circadian Pacemaker Protein RIGUI抗体、Period Homolog 1抗体或HPER抗体），可以通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的Per1蛋白。Per1抗体（E-8）是非偶联型抗Per1抗体。生物钟是负责调节激素节律、睡眠周期和其他行为的生物计时器。位于大脑中的视交叉上核（SCN）是第一个被发现的哺乳动物生物钟。已经确定了一些似乎是SCN时钟分子组分的转录因子。Clock基因内的突变会增加内生周期的长度并导致昼夜节律的丧失。三种哺乳动物周期蛋白，即Per1、Per2和Per3，在SCN中表现出昼夜节律。在主观夜晚，Per1和Per2的RNA水平响应光脉冲而增加，而Per3的RNA水平对光脉冲没有变化。Tim（意为永恒）与Per1和Per2相互作用；Tim和Per1负向调节Clock-BMAL1诱导的转录。Per1蛋白异构体显示出不同的细胞区室化以及组织特异性大小差异。全长Per1异构体主要存在于细胞质中，但也存在较短的核异构体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Per1 抗体 (E-8) 参考文献:

  1. 缺氧会影响小鼠大脑中昼夜节律基因 PER1 和 CLOCK 的表达。  |  Chilov, D., et al. 2001. FASEB J. 15: 2613-22. PMID: 11726537
  2. 通过转基因 BAC 挽救小鼠昼夜节律时钟基因的功能鉴定。  |  Antoch, MP., et al. 1997. Cell. 89: 655-67. PMID: 9160756
  3. 小鼠的 Clock 基因突变表现为反形态，位于 Kit 远端的 W19H 缺失区。  |  King, DP., et al. 1997. Genetics. 146: 1049-60. PMID: 9215907
  4. 哺乳动物的三个周期同源物：嗜睡上皮细胞昼夜节律钟和脑外摆动转录物的不同光反应。  |  Zylka, MJ., et al. 1998. Neuron. 20: 1103-10. PMID: 9655499
  5. 哺乳动物昼夜节律自律环：永恒同源物和 mPer1 相互作用并负向调节 CLOCK-BMAL1 诱导的转录。  |  Sangoram, AM., et al. 1998. Neuron. 21: 1101-13. PMID: 9856465
  6. 哺乳动物视网膜中存在 24 小时昼夜节律时钟。  |  Morell, V. 1996. Science. 272: 349. PMID: 8602520

订购信息

产品名称产品编号规格价格数量收藏夹

Per1 抗体 (E-8)

sc-398890
200 µg/ml
RMB2377.00

Per1 (E-8): m-IgGκ BP-HRP 套装

sc-524524
200 µg Ab, 40 µg BP
RMB2662.00

Per1 (E-8) 中和勝肽

sc-398890 P
100 µg/0.5 ml
RMB511.00

Per1 抗体 (E-8) X

sc-398890 X
200 µg/0.1 ml
RMB2377.00

How do I request a sample for this antibody?

Asked by: A Szemiel
Thank you very much for your inquiry. Please send us an email to [email protected] with the following information: - complete address for shipping - telephone, fax number and e-mail address - a contact person the products should be addressed to - catalogue number and product description Remember once you try the sample, you can write a review in our web about it, indicating all the information you think might be useful for other researchers.
Answered by: Technical Support Europe
Date published: 2017-08-09

What application is the blocking peptide sc-398890 P appropriate for?

Asked by: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-03-01
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Rated 4 out of 5 by from Buen resultadoEl anticuerpo da buen resultado para células HCT-116 de cáncer colorrectal humano en cultivo.
Date published: 2018-05-16
Rated 1 out of 5 by from It is not useful for immunohistochemitryWe processed rat brain tissue sections (perfused in PFA, postfixed in PFA and cryoprotected in sucrose) of the same subject with different dilutions and with a polyclonal antibody that has resulted very good for our purposes. The monoclonal Per-1 (E-8) did not give a good immunostaining. Moreover, it uncovered structures that look like blood vessels and obstruct a good appreciation of the Per-1 IR cells. It is important to indicate that such vessels were not vissible with our reference antibody.
Date published: 2018-04-30
Rated 5 out of 5 by from Great antibodyI used it for IF on mouse brain tissue (perfused in PFA, postfixed in PFA and cryoprotected in sucrose) and it worked perfectly. The concentration used was 1/200 and the incubation was ON at 4C.
Date published: 2018-01-06
Rated 5 out of 5 by from Excellent antibodyPer1 Antibodies is tidy and with a clear robust strip, the WB (1:250) has perfect work.The expressions were much higher.
Date published: 2017-10-27
Rated 4 out of 5 by from Good signalI got this sample around 3 weeks ago, Per1 work in mouse E13 brain tissue,
Date published: 2017-08-04
Rated 3 out of 5 by from ImmunohistochemistryThis antibody works well for immunohistochemistry. Positive staining was observed in human tissues.
Date published: 2017-08-01
Rated 5 out of 5 by from Per1This antibody produced positive Western Blot data of Per1 expression in PC-3 nuclear extract, dilution 1:300, clear signal.
Date published: 2017-06-01
Rated 5 out of 5 by from effect is goodThis antibody has very good sensitivity and specificity for WB with Per1 from mouse testis tissue extract.
Date published: 2017-02-12
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Per1 抗体 (E-8) is rated 4.2 out of 5 by 10.
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