Penicillin G potassium salt CAS: 113-98-4
MF: C16H17KN2O4S
MW: 372.48
A β-lactam antibiotic.

Penicillin G potassium salt (CAS 113-98-4)

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Alternate Names: Benzylpenicillin Potassium Salt
Application: Penicillin G potassium salt is a β-lactam antibiotic
CAS Number: 113-98-4
Molecular Weight: 372.48
Molecular Formula: C16H17KN2O4S
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Penicillin G potassium salt is a salt of Penicillin G. Penicillin G is a hydrophobic, β-lactam antibiotic produced by Penicillium spp. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to Penicillin G. Penicillin G is also known as benzylpenicillin and contains a 6′ phenylacetyl side chain. In acid aqueous solutions, Penicillin is reported to decompose into penillic acid and penilloic acid. Penicillin G is also available as a non-salt (sc-344973) and in salt forms such as Penicillin G sodium (sc-257971).


参考文献

1. Schwartz, M.A. 1965. J Pharm Sci. 54: 472-473. PMID: 14301592
2. Demain, A.L. 1991. Proc. Natl. Sci. Counc. Repub. China B. 15: 251-265. PMID: 1815263
3. Livermore, D.M. 2009. Curr. Protein Pept. Sci. 10: 397-400. PMID: 19538149

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
Storage :
Store at 4° C
Melting Point :
214-217° C (lit.)
Density :
1.36 g/cm3
Refractive Index :
n20D ~1.66 (Predicted)
Optical Activity :
α20/D 285°±15°, c = 1 in water
IC50 :
Penicillin-binding protein 1A: IC50 = 0.002 µg/ml (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2B: IC50 = 0.007 µg/ml (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2x: IC50 = 0.007 µg/ml (Streptococcus pneumoniae serotype 4 ); Bacillus subtilis: IC50 = 1.56 µg/ml; Staphylococcus aureus: IC50 = 1.56 µg/ml
Ki Data :
Beta-lactamase TEM: Ki= 20 µM (Escherichia coli); Solute carrier family 22 member 8: Ki= 52.8 µM (rat); OAT3: Ki= 97.6 µM (human); Solute carrier family 22 member 6: Ki= 328 µM (mouse); Solute carrier family 22 member 6: Ki= 418 µM (rat)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
2
RTECS :
XH9700000
PubChem CID :
23664709
Merck Index :
14: 7094
MDL Number :
MFCD00036193
EC Number :
204-038-0
Beilstein Registry :
3832841
SMILES :
CC1([[email protected]@H](N2[[email protected]](S1)[[email protected]@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]

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