Date published: 2025-9-8

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Pendrin 抗体 (G-11): sc-518108

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说明书
  • Pendrin 抗体 G-11 是小鼠单克隆 IgM (kappa轻链),Pendrin抗体,规格为200 µg/ml
  • 抗原表位位于human来源Pendrin胞外域的462-481氨基酸之间
  • 推荐用于 mouse, rat 和 human 来源的Pendrin WB, IP, IF 和 ELISA检测
  • 抗Pendrin抗体(G-11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Pendrin (G-11): sc-518108免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是Pendrin Antibody (G-11) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与Pendrin Antibody (G-11) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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    関連項目

    Pendrin抗体(G-11)是一种小鼠单克隆IgM抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附(ELISA)等方法检测小鼠、大鼠和人类样本中的Pendrin。Pendrin (G-11) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。Pendrin是一种重要的跨膜蛋白,由位于7号染色体上的基因编码,Pendrin功能障碍与Pendred综合征有关,后者是最常见的综合征性耳聋,表现为先天性感觉神经性听力损失和甲状腺肿。Pendrin在氯离子和碘离子转运中发挥着重要作用,特别是在甲状腺、内耳、胎儿耳蜗和肾脏中,Pendrin有助于肾碳酸氢盐的分泌和离子交换过程。Pendrin在耳蜗内淋巴管和囊以及耳蜗特定区域表达,有助于建立听觉功能所需的离子梯度。这些组织中的Pendrin的存在凸显了Pendrin在维持电解质平衡和正常细胞功能方面的重要性,使Pendrin成为听力损失和相关疾病研究的重要目标。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Pendrin 参考文献:

    1. 彭德综合征基因编码一种氯-碘转运蛋白。  |  Scott, DA., et al. 1999. Nat Genet. 21: 440-3. PMID: 10192399
    2. 彭德氏综合征基因(Pds)的小鼠直向同源物的表达模式表明,pendrin 在内耳中起着关键作用。  |  Everett, LA., et al. 1999. Proc Natl Acad Sci U S A. 96: 9727-32. PMID: 10449762
    3. 在爪蟾卵母细胞中表达的人pendrin可介导氯离子/甲酸盐交换。  |  Scott, DA. and Karniski, LP. 2000. Am J Physiol Cell Physiol. 278: C207-11. PMID: 10644529
    4. 垂体促肾上腺皮质激素和彭德综合征(PDS)基因在人类甲状腺组织中的表达。  |  Bidart, JM., et al. 2000. J Clin Endocrinol Metab. 85: 2028-33. PMID: 10843192
    5. Pendrin:肾皮质顶端的 Cl-/OH-/HCO3- 交换器。  |  Soleimani, M., et al. 2001. Am J Physiol Renal Physiol. 280: F356-64. PMID: 11208611
    6. 垂体促肾上腺皮质激素在肾脏生理中的作用  |  Wall, SM. and Lazo-Fernandez, Y. 2015. Annu Rev Physiol. 77: 363-78. PMID: 25668022
    7. pendrin在血压调节中的作用。  |  Wall, SM. 2016. Am J Physiol Renal Physiol. 310: F193-203. PMID: 26538443
    8. 醛固酮诱导的高血压病理生理学中Pendrin的作用。  |  Shibata, S. 2019. Am J Hypertens. 32: 607-613. PMID: 30982848
    9. 对pendrin(SLC26A4)及其与疾病相关的变体的阴离子转运功能进行系统定量。  |  Wasano, K., et al. 2020. Hum Mutat. 41: 316-331. PMID: 31599023
    10. CFTR和pendrin之间的功能相互作用:生理和病理生理学的相关性。  |  Tamma, G. and Dossena, S. 2022. Front Biosci (Landmark Ed). 27: 75. PMID: 35227018
    11. 彭德综合征是由推测的硫酸盐转运体基因(PDS)突变引起的。  |  Everett, LA., et al. 1997. Nat Genet. 17: 411-22. PMID: 9398842
    12. 彭德综合征 PDS 基因的分子分析。  |  Coyle, B., et al. 1998. Hum Mol Genet. 7: 1105-12. PMID: 9618167

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Pendrin 抗体 (G-11)

    sc-518108
    200 µg/ml
    RMB2377.00

    Pendrin (G-11): m-IgGκ BP-HRP 套装

    sc-551124
    200 µg Ab; 40 µg BP
    RMB2662.00

    Pendrin 抗体 (G-11) AC

    sc-518108 AC
    500 µg/ml, 25% agarose
    RMB3129.00

    Pendrin 抗体 (G-11) HRP

    sc-518108 HRP
    200 µg/ml
    RMB2377.00

    Pendrin 抗体 (G-11) FITC

    sc-518108 FITC
    200 µg/ml
    RMB2482.00

    Pendrin 抗体 (G-11) PE

    sc-518108 PE
    200 µg/ml
    RMB2580.00

    Pendrin 抗体 (G-11) Alexa Fluor® 488

    sc-518108 AF488
    200 µg/ml
    RMB2685.00

    Pendrin 抗体 (G-11) Alexa Fluor® 546

    sc-518108 AF546
    200 µg/ml
    RMB2685.00

    Pendrin 抗体 (G-11) Alexa Fluor® 594

    sc-518108 AF594
    200 µg/ml
    RMB2685.00

    Pendrin 抗体 (G-11) Alexa Fluor® 647

    sc-518108 AF647
    200 µg/ml
    RMB2685.00

    Pendrin 抗体 (G-11) Alexa Fluor® 680

    sc-518108 AF680
    200 µg/ml
    RMB2685.00

    Pendrin 抗体 (G-11) Alexa Fluor® 790

    sc-518108 AF790
    200 µg/ml
    RMB2685.00

    Dear Sirs, what do you recommend as a control for agarose-conjugated Anti-Pendrin Antibody (G-11; mouse monoclonal IgM, kappa light chain)? Optimal would be agarose-conjugated normal mouse IgM. Do you provide this? Thank you!

    Asked by: SDos
    Thank you for your question. You can use normal mouse IgG-AC sc-2343 as isotype control for agarose-conjugated IgM antibodies.
    Answered by: Tech Support Europe
    Date published: 2020-07-29

    I would like to know whether the the mouse thyroid tissue extract by which the antibody was validated is commercial and what kind of extract it is - denaturing or non-denaturing conditions, and what kind of detergent was used. Thank you!

    Asked by: SDos
    Thank you for your question. This mouse thyroid tissue extract is not currently available for purchase. It was prepared using our RIPA Lysis Buffer (sc-24948) and then run on the gel under denaturing conditions with Electrophoresis Sample Buffer (sc-24945) which contains DTT, TCEP-HCl, and SDS.
    Answered by: Technical Support
    Date published: 2020-07-17
    • y_2025, m_9, d_7, h_4CST
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    Rated 5 out of 5 by from Strong detection of human Pendrin by Western BlotAntibody works well by Western Blot with human cell lines SH-SY5Y (middle lane) and COLO 320DM (right lane) Banding pattern resembles the pattern observed by others (Cell Physiol Biochem 2006;17:245-256) -SCBT QC
    Date published: 2023-09-14
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    Pendrin 抗体 (G-11) is rated 5.0 out of 5 by 1.
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