PDGFR Tyrosine Kinase Inhibitor IV (CAS 627518-40-5)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (>10 mg/ml), water (<2 mg/ml), and methanol.

保存 :

Store at -20° C

熔点 :

154° C

沸点 :

~528.8° C at 760 mmHg (Predicted)

密度 :

~1.4 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.67

IC50 :

tumor cell lines: IC₅₀ = <33 nM (human); PDGFR-β: IC₅₀ = 4.2 nM; c-Abl: IC₅₀ = 22 nM; Lck: IC₅₀ = 100 nM; c-Src: IC₅₀ = 185 nM; Fyn: IC₅₀ = 378 nM; VEGFR: IC₅₀ = 3.1 µM; HER-2: IC₅₀ = >10 µM; Cdk′s-1,-2,-4 &-7: IC₅₀ = >10 µM; bFGFR-1: IC₅₀ = 45.8 µM; EGFR: IC₅₀ = >100 µM; PDGFR-α: IC₅₀ = 45 nM; A-375 (Malignant melanoma cells): IC₅₀ = 7 nM (human); NCI-H460 (Non-small cell lung carcinoma): IC₅₀ = 10 nM (human); LoVo (Colon adenocarcinoma cells): IC₅₀ = 17 nM (human)

pK值 :

pK_a: 14.00, pK_b: 3.10

德国水公害等级 :

3

PubChem CID :

SMILES :

COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC