Date published: 2025-9-7
访问圣克鲁斯动物健康

021-6093-6350

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
PDGF Receptor beta/PDGFRB Antibody (18A2) - Immunohistochemistry - Image 352967
PDGFR-β (18A2): sc-19995. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色显示肾小管细胞的胞浆染色.
PDGFR-β (18A2): sc-19995. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色显示肾小管细胞的胞浆染色.

PDGF Receptor beta/PDGFRB 抗体 (18A2): sc-19995

3.7(10)
寫評論提問

说明书
  • PDGF Receptor beta/PDGFRB抗体(18A2)是小鼠单克隆IgG1 κ, 在14篇文献中引用，规格为200 µg/ml
  • 免疫human物种的PDGFR-β
  • PDGF Receptor beta/PDGFRB 抗体 (18A2) 推荐用于IF, IHC(P) 和 FCM，检测human 来源的 PDGF receptor type β
  • 抗PDGF Receptor beta/PDGFRB抗体（18A2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PDGF Receptor beta/PDGFRB (18A2): sc-19995的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是PDGF Receptor beta/PDGFRB Antibody (18A2) 适用于 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与PDGF Receptor beta/PDGFRB Antibody (18A2) 打包提供（请参阅下面的订购信息）。

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

额外PDGFR抗体，包括PDGFR-α, PDGFR-β和PDGFRL

PDGFR-β抗体（18A2）是一种小鼠单克隆IgG1κ轻链抗体，可通过免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测人类来源的PDGF受体β。PDGFR-β单克隆抗体（18A2）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。血小板衍生生长因子（PDGF）受体β型在细胞信号传导中起着至关重要的作用，特别是在细胞生长、存活和迁移的调节中，这些是组织修复和发育的重要过程。PDGFR-β主要位于间充质细胞和胶质细胞的表面，PDGFR-β在这里介导其配体PDGF-BB的作用，导致受体二聚化和下游信号传导途径的激活。PDGFR-β能够与PDGF的B亚基特异性结合，这是其发挥功能的关键，因为PDGFR-β能够引发一系列影响细胞行为的细胞内事件。PDGFR-β信号传导失调与多种疾病有关，包括慢性粒细胞白血病（CMML），这凸显了PDGFR-β作为癌症治疗靶点的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PDGF Receptor beta/PDGFRB 抗体 (18A2) 参考文献:

  1. PDGFR-β(+)细胞产生促红细胞生成素。  |  Gerl, K., et al. 2016. Pflugers Arch. 468: 1479-87. PMID: 27220347
  2. PDGFR-β在小鼠局灶性脑缺血模型中恢复血脑屏障功能。  |  Shen, J., et al. 2019. J Cereb Blood Flow Metab. 39: 1501-1515. PMID: 29629621
  3. PDGF-B/PDGFR-BETA轴在乳腺正常发育和癌变中的作用。  |  Jitariu, AA., et al. 2018. Crit Rev Oncol Hematol. 131: 46-52. PMID: 30293705
  4. PDGFR-β信号调节心肌细胞增殖和心肌再生。  |  Yue, Z., et al. 2019. Cell Rep. 28: 966-978.e4. PMID: 31340157
  5. 间质 PDGFR-β 失调导致肾脏纤维化  |  Buhl, EM., et al. 2020. EMBO Mol Med. 12: e11021. PMID: 31943786
  6. PDGFR-β+成纤维细胞在人类实体肿瘤中的存活率下降：荟萃分析。  |  Hu, G., et al. 2021. Aging (Albany NY). 13: 13693-13707. PMID: 33946048
  7. 癌相关成纤维细胞通过PDGF-BB/PDGFR-β介导的旁分泌信号网络促进胆管癌的淋巴转移。  |  Yan, J., et al. 2024. Aging Dis. 15: 369-389. PMID: 37307823
  8. 抑制PDGFRβ可减轻线粒体自噬后DRP-1过度表达和线粒体融合失败引起的内皮细胞凋亡损伤。  |  An, X., et al. 2023. Cell Death Dis. 14: 756. PMID: 37980402
  9. 靶向内皮 PDGFR-β 可通过 PAK1/NICD 轴促进血管生成相关骨形成。  |  Lin, H., et al. 2024. J Cell Physiol. 239: e31291. PMID: 38721633
  10. 巨噬细胞衍生的PDGF-BB通过PDGFR-β/TXNIP通路调节髓核细胞的糖酵解酶表达和热解作用。  |  Zheng, X., et al. 2024. Osteoarthritis Cartilage. 32: 1245-1260. PMID: 38744373

订购信息

产品名称产品编号规格价格数量收藏夹

PDGF Receptor beta/PDGFRB 抗体 (18A2)

sc-19995
200 µg/ml
RMB2377.00

PDGF Receptor beta/PDGFRB (18A2): m-IgG Fc BP-HRP 套装

sc-528345
200 µg Ab; 10 µg BP
RMB2662.00

PDGF Receptor beta/PDGFRB (18A2): m-IgGκ BP-HRP 套装

sc-520699
200 µg Ab, 40 µg BP
RMB2662.00

PDGF Receptor beta/PDGFRB (18A2): m-IgG1 BP-HRP 套装

sc-542881
200 µg Ab; 20 µg BP
RMB2662.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) AC

sc-19995 AC
500 µg/ml, 25% agarose
RMB3129.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) HRP

sc-19995 HRP
200 µg/ml
RMB2377.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) FITC

sc-19995 FITC
200 µg/ml
RMB2482.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) PE

sc-19995 PE
200 µg/ml
RMB2580.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 488

sc-19995 AF488
200 µg/ml
RMB2685.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 546

sc-19995 AF546
200 µg/ml
RMB2685.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 594

sc-19995 AF594
200 µg/ml
RMB2685.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 647

sc-19995 AF647
200 µg/ml
RMB2685.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 680

sc-19995 AF680
200 µg/ml
RMB2685.00

PDGF Receptor beta/PDGFRB 抗体 (18A2) Alexa Fluor® 790

sc-19995 AF790
200 µg/ml
RMB2685.00

Hello, what buffer do you recommend for antigen unmasking for PDFGR-beta (sc-19995). Thank you,

Asked by: Anna1
We recommend using sodium citrate buffer (pH 6.0) and heat treatment for antigen retrieval on formalin-fixed paraffin-embedded tissue sections.
Answered by: Technical Support
Date published: 2019-09-11

Can PDGFR-β (18A2): sc-19995 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, PDGFR-β (18A2): sc-19995 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_9, d_7, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_19995, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 107ms
  • QUESTIONS, PRODUCT
Rated 1 out of 5 by from Doesn't work on frozen human kidney sectionsNo staining on frozen human kidney at 1:50 or 1:100 dilutions
Date published: 2020-08-17
Rated 5 out of 5 by from Tested on HFFF by FACSThis mab gives a very nice signal by indirect FCM on HFFFs cells
Date published: 2019-03-14
Rated 1 out of 5 by from Not valid for IF on rat frozen liver sectionsRat liver frozen sections were subjected to immunofluorescence using PDGFR-β (D-6) antibody. Antigen retrieval methods were optimized between without antigen retrieval, heat-induced citrate buffer, and trypsin-induced antigen retrieval. However, a positive signal was not clear on each slide.
Date published: 2018-02-28
Rated 5 out of 5 by from Great results for Flow citometryI received this antibody as a free sample. I used it for FACS and it worked very well. I worked with HFF(Human Foreskin Fibroblast) and Primary Breast Cancer Cells. First I tried with a dilution of 1ul per 100000 cells in HFF and the result wasn´t the expected. After, I used a dilution of 2ul per 100000 cells of HFF and 2ul per 200000 Primary Breast Cancer Cells. This time I obteined better results.
Date published: 2017-11-22
Rated 5 out of 5 by from Great Antibody for IHC and IFStrong, clear signal with little to no background. Beautiful tissue staining and IF imaging.
Date published: 2017-01-24
Rated 4 out of 5 by from Produced wonderful immunoperoxidase cytoplasmicProduced wonderful immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human placenta tissue. -SCBT QC
Date published: 2015-05-17
Rated 4 out of 5 by from Strong staining in IHC in human localizedStrong staining in IHC in human localized prostate cancer tissue. -SCBT Publication Review
Date published: 2015-05-15
Rated 4 out of 5 by from Worked well in WB in human thoracic aortasWorked well in WB in human thoracic aortas. -SCBT Publication Review
Date published: 2015-04-17
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_19995, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 26ms
  • REVIEWS, PRODUCT
PDGF Receptor beta/PDGFRB 抗体 (18A2) is rated 3.7 out of 5 by 10.
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_10
  • loc_zh_CN, sid_19995, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 105ms
  • REVIEWS, PRODUCT
021-6093-6350
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打0086-021-60936350联系我们。
版权所有© 2007-2025 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。