Date published: 2025-9-7

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PDGF Receptor alpha/PDGFRA 抗体 (16A1): sc-21789

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说明书
  • PDGF Receptor alpha/PDGFRA抗体(16A1)是小鼠单克隆IgG1 κ, 在12篇文献中引用,规格为200 µg/ml
  • 针对human来源NIH/3T3细胞转染PDGFR-α的
  • 抗-PDGF Receptor alpha/PDGFRA 抗体 (16A1) 推荐用于 IF 和 FCM,检测mouse, rat 和human 来源的 PDGFR-α
  • 抗PDGF Receptor alpha/PDGFRA抗体(16A1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PDGF Receptor alpha/PDGFRA (16A1): sc-21789免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是PDGF Receptor alpha/PDGFRA Antibody (16A1). 的首选辅助检测试剂,这些试剂现与PDGF Receptor alpha/PDGFRA Antibody (16A1) 打包提供(请参阅下面的订购信息)。

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関連項目

PDGFR-α抗体(16A1)是一种小鼠单克隆IgG1κ轻链抗体,可通过免疫荧光(IF)和流式细胞术(FCM)检测小鼠、大鼠和人类样本中的PDGFR-α。抗PDGFR-α抗体(16A1)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。血小板衍生生长因子受体α(PDGFR-α)在细胞增殖、存活和迁移等过程中发挥着关键作用,因此PDGFR-α对于正常发育和组织修复至关重要。PDGFR-α主要位于细胞表面,与PDGF-AA和PDGF-AB配体相互作用,启动影响细胞行为的信号级联。PDGFR-α在配体结合后形成同二聚体和异二聚体的能力对于其功能至关重要,因为这种形成决定了信号反应的特异性和强度。PDGFR-α信号传导失调与多种疾病有关,包括癌症和纤维化疾病,这凸显了PDGFR-α在健康和疾病中的重要性。PDGFR-α单克隆抗体(16A1)是研究人员研究这些关键生物过程及其对疾病的影响的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PDGF Receptor alpha/PDGFRA 抗体 (16A1) 参考文献:

  1. 石杉碱对大鼠肺肌成纤维细胞中 PDGFR-α 的调节作用  |  Lindroos, PM., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 280: L354-62. PMID: 11159015
  2. 通过非生物活性测定法测得的抗 PDGFR-α 抗体对系统硬化症没有特异性。  |  Balada, E., et al. 2008. Ann Rheum Dis. 67: 1027-9. PMID: 18272670
  3. 抑制 PDGFR-α 可保护脑出血后的血脑屏障。  |  Ma, Q., et al. 2011. Ann Neurol. 70: 920-31. PMID: 22190365
  4. 鼻腔NK/T细胞淋巴瘤中Ku80和PDGFR-α的表达及其意义  |  Li, J., et al. 2016. Pathol Res Pract. 212: 204-9. PMID: 26778387
  5. 两类 PDGF 受体可识别不同的 PDGF 异构体。  |  Hart, CE., et al. 1988. Science. 240: 1529-31. PMID: 2836952
  6. 不同二聚体形式的 PDGF 与人类成纤维细胞的结合:两种不同受体类型的证据。  |  Heldin, CH., et al. 1988. EMBO J. 7: 1387-93. PMID: 2842148
  7. 血小板衍生生长因子的生物学  |  Ross, R., et al. 1986. Cell. 46: 155-69. PMID: 3013421
  8. Alcam-a和Pdgfr-α对支持造血的硬骨瘤衍生基质细胞的发育至关重要。  |  Murayama, E., et al. 2023. Nat Commun. 14: 1171. PMID: 36859431
  9. PDGFRα+ITGA11+成纤维细胞通过ITGA11-SELE相互作用促进早期癌症淋巴管侵袭和淋巴转移  |  Zheng, H., et al. 2024. Cancer Cell. 42: 682-700.e12. PMID: 38428409
  10. 对 PDGFR-α 进行免疫组化分析以确定伤口年龄。  |  Zhang, W., et al. 2024. Int J Legal Med. 138: 1351-1356. PMID: 38520552
  11. 来自异源二聚体受体复合物的血小板衍生物生长因子α受体中一个独特的自磷酸化位点。  |  Rupp, E., et al. 1994. Eur J Biochem. 225: 29-41. PMID: 7523122
  12. 血小板衍生生长因子α受体中酪氨酸 720 的磷酸化是 Grb2 和 SHP-2 结合所必需的,但不是激活 Ras 或细胞增殖所必需的。  |  Bazenet, CE., et al. 1996. Mol Cell Biol. 16: 6926-36. PMID: 8943348

订购信息

产品名称产品编号规格价格数量收藏夹

PDGF Receptor alpha/PDGFRA 抗体 (16A1)

sc-21789
200 µg/ml
RMB2377.00

PDGF Receptor alpha/PDGFRA (16A1): m-IgG Fc BP-HRP 套装

sc-526616
200 µg Ab; 10 µg BP
RMB2662.00

PDGF Receptor alpha/PDGFRA (16A1): m-IgG1 BP-HRP 套装

sc-531989
200 µg Ab; 20 µg BP
RMB2662.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) AC

sc-21789 AC
500 µg/ml, 25% agarose
RMB3129.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) HRP

sc-21789 HRP
200 µg/ml
RMB2377.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) FITC

sc-21789 FITC
200 µg/ml
RMB2482.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) PE

sc-21789 PE
200 µg/ml
RMB2580.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 488

sc-21789 AF488
200 µg/ml
RMB2685.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 546

sc-21789 AF546
200 µg/ml
RMB2685.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 594

sc-21789 AF594
200 µg/ml
RMB2685.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 647

sc-21789 AF647
200 µg/ml
RMB2685.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 680

sc-21789 AF680
200 µg/ml
RMB2685.00

PDGF Receptor alpha/PDGFRA 抗体 (16A1) Alexa Fluor® 790

sc-21789 AF790
200 µg/ml
RMB2685.00

Can PDGFR-α (16A1): sc-21789 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, PDGFR-α (16A1): sc-21789 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Indirect FCM on HFFF cellsThis antibody was tested on HFFF cells by FACS and shown a clear signal .
Date published: 2019-03-14
Rated 4 out of 5 by from Good stainingsuccessful staining on human fibroblasts. I'm really satisfied whit this antibody
Date published: 2019-02-05
Rated 5 out of 5 by from Great featuresI was really excited that this antibody has no background and worked very well.
Date published: 2017-01-13
Rated 4 out of 5 by from Worked well in IHC in mouse brain tissuesWorked well in IHC in mouse brain tissues. -SCBT Publication Review
Date published: 2014-11-01
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PDGF Receptor alpha/PDGFRA 抗体 (16A1) is rated 4.3 out of 5 by 4.
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