Date published: 2025-9-8

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PDE1C 抗体 (D-10): sc-166044

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说明书
  • PDE1C抗体(D-10)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 针对氨基酸448-709的抗原,在PDE1C的C-terminus处映射,human来源
  • 推荐用于 human 来源的PDE1C WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRP是PDE1C Antibody (D-10) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与PDE1C Antibody (D-10) 打包提供(请参阅下面的订购信息)。

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    関連項目

    磷酸二酯酶(PDE,也称为环核苷酸磷酸二酯酶)对于下调细胞内第二信使环腺苷酸(cAMP)和环鸟苷酸(cGMP)水平至关重要。PDE1家族是钙调素依赖性(CaM-PDE)蛋白质,通过钙-钙调素复合物受到刺激,并具有将cAMP水解为5'AMP和将cGMP水解为5'GMP的功能。PDE1C(磷酸二酯酶1C),也称为HCAM3,是一种广泛表达的蛋白质,对cAMP和cGMP都有很高的亲和力。由于C末端的可变剪接,存在两种异构体,称为PDE1C1和PDE1C2。虽然这两种异构体在整个身体中都以低水平表达,但PDE1C2主要在脑和心脏中表达,而PDE1C1主要在脑、心脏和肺中表达。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PDE1C 抗体 (D-10) 参考文献:

    1. 钙/钙调蛋白依赖性磷酸二酯酶 PDE1C 可下调葡萄糖诱导的胰岛素分泌。  |  Han, P., et al. 1999. J Biol Chem. 274: 22337-44. PMID: 10428803
    2. 环核苷酸磷酸二酯酶-1C(PDE1C)在体外驱动多形性胶质母细胞瘤细胞的增殖、迁移和侵袭。  |  Rowther, FB., et al. 2016. Mol Carcinog. 55: 268-79. PMID: 25620587
    3. PDE1C 缺乏可拮抗病理性心脏重塑和功能障碍。  |  Knight, WE., et al. 2016. Proc Natl Acad Sci U S A. 113: E7116-E7125. PMID: 27791092
    4. PDE1C 基因的显性变异与非综合征性听力损失有关。  |  Wang, L., et al. 2018. Hum Genet. 137: 437-446. PMID: 29860631
    5. EPAC1/PDE1C信号轴调控极化人动脉血管平滑肌细胞前缘突起的形成  |  Brzezinska, P. and Maurice, DH. 2019. Cells. 8: PMID: 31757003
    6. 敲除 hsa_circ_0134111 可通过海绵状 microRNA-224-5p 减轻骨关节炎的症状。  |  Zhang, L., et al. 2021. Cell Cycle. 20: 1052-1066. PMID: 33945396
    7. 环核苷酸磷酸二酯酶 1C 是腹主动脉瘤的诱因。  |  Zhang, C., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34312235
    8. 单细胞基因组学揭示痴呆症的跨障碍和疾病特异性途径。  |  Rexach, JE., et al. 2024. Cell. 187: 5753-5774.e28. PMID: 39265576
    9. Circ-PDE1C/miR-766-3p/SGTB轴调节IL-1β诱导的人软骨细胞凋亡、炎症和氧化应激。  |  Gao, L., et al. 2024. Adv Rheumatol. 64: 92. PMID: 39736775
    10. 钙调素刺激的环核苷酸磷酸二酯酶(PDE1C)在合成增殖表型的人类动脉平滑肌细胞中被诱导。  |  Rybalkin, SD., et al. 1997. J Clin Invest. 100: 2611-21. PMID: 9366577

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PDE1C 抗体 (D-10)

    sc-166044
    200 µg/ml
    RMB2377.00

    PDE1C (D-10): m-IgG Fc BP-HRP 套装

    sc-539995
    200 µg Ab; 10 µg BP
    RMB2662.00

    PDE1C (D-10): m-IgG2b BP-HRP 套装

    sc-549763
    200 µg Ab; 10 µg BP
    RMB2662.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with PDE1C (D-10): sc-166044 monoclonal antibody?

    Asked by: Cweed
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Produced nice Western blot data of PDE1CProduced nice Western blot data of PDE1C expression in WI 38 whole cell lysate. -SCBT QC
    Date published: 2013-01-04
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    PDE1C 抗体 (D-10) is rated 5.0 out of 5 by 1.
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