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Pdcd-4 Antibody (k4C1) - Western Blotting - Image 57420
Pdcd-4 抗体 (k4C1): sc-130545. SK-BR-3 全细胞裂解液中 Pdcd-4 表达的 Western 印迹分析.
Pdcd-4 Antibody (k4C1) - Western Blotting - Image 57420
Pdcd-4 抗体 (k4C1): sc-130545. SK-BR-3 全细胞裂解液中 Pdcd-4 表达的 Western 印迹分析.
Pdcd-4 Antibody (k4C1) - Western Blotting - Image 47901
Pdcd-4 抗体 (k4C1): sc-130545. Hep G2 全细胞裂解液中 Pdcd-4 表达的 Western 印迹分析.
Pdcd-4 Antibody (k4C1) - Western Blotting - Image 58766
Pdcd-4 抗体 (k4C1): sc-130545. 未转染 293T: sc-117752 (A), 转染人 Pdcd-4 的 293T: sc-176183 (B) 和 SK-BR-3 (C) 全细胞裂解液中 Pdcd-4 表达的 Western 印迹分析.
Pdcd-4 抗体 (k4C1): sc-130545. SK-BR-3 全细胞裂解液中 Pdcd-4 表达的 Western 印迹分析.

Pdcd-4 抗体 (k4C1): sc-130545

5.0(7)
寫評論提問

说明书
  • Pdcd-4 抗体 k4C1 是小鼠单克隆 IgG1, 在13篇文献中引用，提供 50 µg/0.5 ml
  • 与全长重组蛋白Pdcd-4（human起源）杂交
  • 推荐用于 human 来源的Pdcd-4 WB, IP 和 ELISA检测
  • 目前，我们还没有完成Pdcd-4 抗体 (k4C1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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研究信息

関連項目

此外 Programmed Cell Death 抗体包括 Pdcd-1, Pdcd-2, Pdcd-4, Pdcd-7 和 Pdcd2L

转化抑制基因Pdcd-4（程序性细胞死亡基因4）抑制肿瘤促进剂介导的小鼠角质形成细胞的转化，是人类肺癌发展中的潜在抑癌基因。生化分析表明，Pdcd-4蛋白参与蛋白质翻译以及核事件。Pdcd-4直接与RNA解旋酶eIF4A相互作用，并通过干扰帽依赖的翻译起始复合物的组装来抑制蛋白质合成。Pdcd-4还抑制c-Jun对AP-1响应启动子的反式激活，这表明Pdcd-4的转化抑制活性可能至少部分是由于抑制c-Jun活性。除了影响c-Jun磷酸化外，Pdcd-4还阻断c-Jun对共激活因子p300的招募。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Pdcd-4 抗体 (k4C1) 参考文献:

  1. DTL 通过 PDCD4 泛素依赖性降解促进癌症进展。  |  Cui, H., et al. 2019. J Exp Clin Cancer Res. 38: 350. PMID: 31409387
  2. 西诺明通过调节 miR-29/PDCD-4 轴抑制乳腺癌细胞的增殖、迁移和侵袭  |  Gao, G., et al. 2019. Artif Cells Nanomed Biotechnol. 47: 3839-3846. PMID: 31556312
  3. PDCD4 限制了促癌神经胶质蛋白-ErbB 信号转导。  |  Montero, JC. and Pandiella, A. 2021. Cell Mol Life Sci. 78: 1799-1815. PMID: 32804243
  4. MicroRNA-16、程序性细胞死亡蛋白-4（PDCD-4）与多囊卵巢综合征。  |  Zehra, N., et al. 2020. J Coll Physicians Surg Pak. 30: 880-881. PMID: 32893806
  5. 右美托咪定通过下调 mircoRNA-21/PDCD 4 轴抑制腹主动脉瘤的发展。  |  Yu, Q., et al. 2021. Int J Mol Med. 47: PMID: 33786608
  6. 剖析 PDCD4 在乳腺癌中的作用  |  Cai, Q., et al. 2022. Front Oncol. 12: 855807. PMID: 35795053
  7. PDCD4 以 eIF4A 依赖性方式限制 PRRSV 复制，并被病毒非结构蛋白 9 拮抗。  |  Wei, R., et al. 2024. J Virol. 98: e0006024. PMID: 38557170
  8. 人类肿瘤抑制因子 PDCD4 直接与核糖体相互作用，抑制翻译。  |  Ye, X., et al. 2024. Cell Res. 34: 522-525. PMID: 38641729
  9. 通过促进 Daxx 介导的 PPARγ/IL-10 信号传导，小胶质细胞 Pdcd4 缺乏症可减轻神经炎症相关的抑郁症。  |  Li, Y., et al. 2024. J Neuroinflammation. 21: 143. PMID: 38822367
  10. 肝细胞中 PDCD4 的缺乏会通过增强 MHC II 类转录因子的表达而加剧非酒精性脂肪性肝炎。  |  Lu, K., et al. 2024. Metabolism. 161: 156036. PMID: 39342987

订购信息

产品名称产品编号规格价格数量收藏夹

Pdcd-4 抗体 (k4C1)

sc-130545
50 µg/0.5 ml
RMB2377.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Pdcd-4 (k4C1): sc-130545 antibody?

Asked by: Randy McDonald
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Great product!!!I bought this antibody several weeks ago and it works well on my WB.
Date published: 2019-08-12
Rated 5 out of 5 by from Published for WB in zebrafish embryosPublished for WB in zebrafish embryos. -SCBT Publication Review
Date published: 2015-06-29
Rated 5 out of 5 by from Robust signal in WB in SKRobust signal in WB in SK-BR-3 whole cell lysate. -SCBT QC
Date published: 2015-05-11
Rated 5 out of 5 by from Positive band in WB in human transfectedPositive band in WB in human transfected 293T and SK-BR-3 whole cell lysates. -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by from Good publishable data in WB in rat cardiacGood publishable data in WB in rat cardiac myocytes. -SCBT Publication Review
Date published: 2015-03-25
Rated 5 out of 5 by from Good pulldown in IP in human MCFGood pulldown in IP in human MCF-7 cells. -SCBT Publication Review
Date published: 2015-03-17
Rated 5 out of 5 by from Strong band in WB in HepG2 whole cell lysateStrong band in WB in HepG2 whole cell lysate. -SCBT QC
Date published: 2013-09-28
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Pdcd-4 抗体 (k4C1) is rated 5.0 out of 5 by 7.
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