PCNA 抗体 (F-2): sc-25280
- PCNA(F-2) is a mouse monoclonal IgG2a κ, cited in 391 publications, provided at 200 µg/ml
- Anti-PCNA(F-2) is recommended for detection in mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- 抗PCNA抗体（F-2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
- 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
- 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
- 关于如何获取PCNA (F-2): sc-25280的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 PCNA 抗体 (F-2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PCNA 抗体 (F-2) 组合成套装提供。 (请参阅下面的订购信息)。
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関連項目
Proliferating Cell Nuclear Antigen, also known as cyclin, is a highly conserved nuclear protein that plays a critical role in DNA replication and repair. Functioning as a sliding clamp, Proliferating Cell Nuclear Antigen forms a homotrimeric ring around DNA, facilitating the processivity of DNA polymerases delta (δ) and epsilon (ε) during replication. This allows Proliferating Cell Nuclear Antigen to act as a scaffold for recruiting various proteins that are key players in DNA repair, chromatin remodeling, and the regulation of the cell cycle. Proliferating Cell Nuclear Antigen expression peaks during the S phase of the cell cycle, making it a useful marker for cell proliferation studies. Proliferating Cell Nuclear Antigen is widely used in research to investigate the mechanisms governing DNA replication, genome stability, and cellular responses to DNA damage. Playing a crucial role in various DNA repair pathways, such as nucleotide excision repair, base excision repair, and mismatch repair, Proliferating Cell Nuclear Antigen interacts with key proteins to fix DNA lesions and correct base-pair mismatches after replication. Proliferating Cell Nuclear Antigen is involved in chromatin assembly and nucleosome formation, which are critical for maintaining genomic integrity during replication and repair processes. Post-translational modifications, such as ubiquitination and sumoylation, play a significant role in regulating Proliferating Cell Nuclear Antigen’s functions, particularly in DNA damage tolerance pathways like translesion synthesis and template switching. These modifications ensure that Proliferating Cell Nuclear Antigen can function effectively even when the cell encounters damaged DNA, aiding in genome maintenance. In cancer research, Proliferating Cell Nuclear Antigen is particularly important due to its overexpression in highly proliferative tumor cells. The high proliferation rates of cancer cells make Proliferating Cell Nuclear Antigen a significant biomarker for both diagnosis and prognosis. Proliferating Cell Nuclear Antigen also serves as a promising target for developing novel cancer therapies, as modulating Proliferating Cell Nuclear Antigen or its interactions could inhibit tumor growth.
仅限研究使用。不适用于诊断和治疗用途。
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
PCNA 抗体 (F-2) | sc-25280 | 200 µg/ml | RMB2377.00 | |||
PCNA (F-2): m-IgG Fc BP-HRP 套装 | sc-528392 | 200 µg Ab; 10 µg BP | RMB2662.00 | |||
PCNA (F-2): m-IgGκ BP-HRP 套装 | sc-520762 | 200 µg Ab, 40 µg BP | RMB2662.00 | |||
PCNA (F-2): m-IgG2a BP-HRP 套装 | sc-547083 | 200 µg Ab; 10 µg BP | RMB2662.00 | |||
PCNA 抗体 (F-2) AC | sc-25280 AC | 500 µg/ml, 25% agarose | RMB3129.00 | |||
PCNA 抗体 (F-2) HRP | sc-25280 HRP | 200 µg/ml | RMB2377.00 | |||
PCNA 抗体 (F-2) FITC | sc-25280 FITC | 200 µg/ml | RMB2482.00 | |||
PCNA 抗体 (F-2) PE | sc-25280 PE | 200 µg/ml | RMB2580.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 488 | sc-25280 AF488 | 200 µg/ml | RMB2685.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 546 | sc-25280 AF546 | 200 µg/ml | RMB2685.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 594 | sc-25280 AF594 | 200 µg/ml | RMB2685.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 647 | sc-25280 AF647 | 200 µg/ml | RMB2685.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 680 | sc-25280 AF680 | 200 µg/ml | RMB2685.00 | |||
PCNA 抗体 (F-2) Alexa Fluor® 790 | sc-25280 AF790 | 200 µg/ml | RMB2685.00 |