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PAR-4 Antibody (5F4) - Western Blotting - Image 348982
PAR-4 抗体 (5F4): sc-293206. 人重组 PAR-4 融合蛋白的 Western 印迹分析.
PAR-4 Antibody (5F4) - Western Blotting - Image 348982
PAR-4 抗体 (5F4): sc-293206. 人重组 PAR-4 融合蛋白的 Western 印迹分析.
PAR-4 抗体 (5F4): sc-293206. 人重组 PAR-4 融合蛋白的 Western 印迹分析.

PAR-4 抗体 (5F4): sc-293206

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说明书
  • PAR-4 抗体 5F4 是小鼠单克隆 IgG1 (kappa轻链)，PAR-4抗体，规格为100 µg/ml
  • 免疫human物种的PAR-4的氨基酸18-82
  • 推荐用于 human 来源的PAR-4 WB, IP 和 ELISA检测
  • 目前，我们还没有完成PAR-4 抗体 (5F4)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    描述
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    说明书与实验方案

    関連項目

    此外 PAR 抗体包括 PAR-2, PAR-3, PAR-4 和 Thrombin R

    PAR-4抗体（5F4）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测人类PAR-4蛋白。抗PAR-4抗体（5F4）有非结合形式。PAR-4，也称为蛋白酶激活受体4，在调节血小板活化和血栓形成方面起着至关重要的作用，因此PAR-4对于维持止血功能至关重要。作为蛋白酶激活受体家族的一员，PAR-4受凝血酶（一种切割受体的丝氨酸蛋白酶）激活，导致一系列细胞内信号传导事件，最终导致细胞内钙水平升高和血小板聚集。这一过程对于机体对血管损伤的反应至关重要，因为PAR-4有助于形成稳定的血凝块，防止过度出血。此外，PAR-4与其他蛋白质（如PAR-1和PAR-2）的相互作用凸显了PAR-4在血栓形成和炎症的复杂信号通路网络中的重要性。了解PAR-4的功能和相互作用对于制定针对凝血障碍和炎症性疾病的治疗策略至关重要。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PAR-4 抗体 (5F4) 参考文献:

    1. 蛋白酶活化受体 1 和 4 介导凝血酶对人体血小板的激活。  |  Kahn, ML., et al. 1999. J Clin Invest. 103: 879-87. PMID: 10079109
    2. 人类角质形成细胞中存在不同于凝血酶受体的蛋白酶活化受体的证据。  |  Santulli, RJ., et al. 1995. Proc Natl Acad Sci U S A. 92: 9151-5. PMID: 7568091
    3. 蛋白酶激活受体 2 和凝血酶受体的激动剂识别。细胞外环相互作用对受体功能的重要性。  |  Lerner, DJ., et al. 1996. J Biol Chem. 271: 13943-7. PMID: 8662993
    4. 人内皮细胞中的蛋白酶活化受体 2 受炎症介质诱导。与凝血酶受体的比较。  |  Nystedt, S., et al. 1996. J Biol Chem. 271: 14910-5. PMID: 8663011
    5. 人类蛋白酶活化受体-3（PAR-3）基因。在 Par 基因簇中进行鉴定，并在血管内皮细胞和血小板中进行表征。  |  Schmidt, VA., et al. 1998. J Biol Chem. 273: 15061-8. PMID: 9614115
    6. 人类蛋白酶激活受体 4 的克隆和特征描述。  |  Xu, WF., et al. 1998. Proc Natl Acad Sci U S A. 95: 6642-6. PMID: 9618465
    7. 凝血酶  |  Goldsack, NR., et al. 1998. Int J Biochem Cell Biol. 30: 641-6. PMID: 9695019
    8. 分析通过凝血酶受体途径介导超极化的 Ca2+ 激活的 K+ 通道。  |  Sullivan, R., et al. 1998. Am J Physiol. 275: C1342-8. PMID: 9814983

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PAR-4 抗体 (5F4)

    sc-293206
    100 µg/ml
    		RMB2377.00

    May I know whether this antibodies are suitable and can be used for flow cytometry analysis?

    Asked by: LLouise
    Thank you for your question. This antibody has not been tested for Flow cytometry use, and is not recommended or warrantied for this use. If you have any further questions, please contact Technical Service or your local distributor for further information.
    Answered by: Tech Service
    Date published: 2019-03-12

    For Western Blot, is it recommended to use denatured or non-denatured conditions with PAR-4 (5F4): sc-293206 antibody?

    Asked by: Trav11
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27

    Hi, I am looking for antibodies specific to Epstein-Barr Virus Thymidine Kinase. May I know whether this antibodies are suitable and can be used for western blott?

    Asked by: Nurur Raudhah
    Thank you for your question. We are not aware of this Par-4 antibody being able to detect Epstein-Barr Virus, nor Thymidine Kinase. We do have quite a few EBV reactive antibodies: https://www.scbt.com/scbt/browse/antibodies-Primary-Antibodies-non-mammalian-antibodies-ebv-Antibodies/_/N-1rjyhy4?Nr=AND%28product.siteId%3AscbtSite%2COR%28product.catalogId%3AscbtCatalog%29%2Cproduct.webDisplayFlag%3A1%2Cproduct.suppressDisplayFlag%3A0%29 and here is a link to our Thymidine Kinases, all of which are only human reactive: https://www.scbt.com/scbt/browse/antibodies-Primary-Antibodies-kinases-and-phosphatases-antibodies-thymidine-kinase-Antibodies/_/N-1fealo9 If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: [email protected] or by live chat directly on our website, www.scbt.com
    Answered by: Tech Service
    Date published: 2017-03-17
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant PAR-4 fusion protein by Western Blot. -SCBT QC
    Date published: 2023-09-14
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    PAR-4 抗体 (5F4) is rated 5.0 out of 5 by 1.
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