PAC 1 (CAS 315183-21-2)

物理状态 :

Solid

溶解度 :

Soluble in 1eq. HCl (75 nM), DMSO (100 mM), deionized water (≤2 mg/mL), water (0.25 mg/mL) at 25° C, ethanol (~5 mg/mL), DMSO:PBS(PH 7.2)(1:3), DMF (~30 mg/ml), and 1:3 solution of ethanol :PBS(PH 7.2) (~0.25 mg/ml).

保存 :

Store at 4° C

熔点 :

250.41° C (Mean or Weighted MP)

沸点 :

580.94° C (Adapted Stein & Brown method)

IC50 :

: IC₅₀ = 3 nM (cancer cells); Adjacent normal tissue: IC₅₀ = 3.2-8.5 µM (cancer cells); Procaspase-3: EC₅₀50 = 0.22 µM; Procaspase-7: EC₅₀50 = 4.5 µM; : IC₅₀ = 0.003-1.41 µM (Cancerous cells); : IC₅₀ = 5.02-9.98 µM (Non-cancerous cells ); Caspase-3: IC₅₀ = 0.35 µM (human); Mutant procaspase-3 with DAD: EC₅₀50 = 2.77 µM; Mutant procaspase-3 with DDA: EC₅₀50 = 113 µM; Mutant procaspase-3 with ADD : EC₅₀50 = 131 µM

pK值 :

pK_a: 8.78, pK_b: 6.65

德国水公害等级 :

3

PubChem CID :

MDL 号码 :

MFCD03302441

SMILES :

C=CCc1cccc(/C=N/NC(=O)CN2CCN(CC2)Cc2ccccc2)c1O