Date published: 2025-9-7
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p57 Kip2 Antibody (KP39) - Western Blotting - Image 44027
p57 Kip2 抗体 (KP39): sc-56341. 对 Jurkat 全细胞裂解液中 p57 Kip2 的表达进行 Western 印迹分析.
p57 Kip2 抗体 (KP39): sc-56341. 对 Jurkat 全细胞裂解液中 p57 Kip2 的表达进行 Western 印迹分析.

p57 Kip2 抗体 (KP39): sc-56341

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说明书
  • p57 Kip2 抗体 KP39 是小鼠单克隆 IgG2b κ，p57 Kip2抗体, 在22篇文献中引用，规格为200 µg/ml
  • 针对全长p57 Kip2，human起源
  • p57 Kip2 抗体 (KP39) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 p57 Kip2
  • 抗p57 Kip2抗体（KP39）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取p57 Kip2 (KP39): sc-56341的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2b BP-HRP 是 p57 Kip2 抗体 (KP39) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与p57 Kip2 抗体 (KP39) 组合成套装提供。 (请参阅下面的订购信息)。

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研究信息

関連項目

p57 Kip2抗体（KP39）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的p57 Kip2蛋白。p57 Kip2抗体（KP39）有非 以及各种结合形式，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。p57 Kip2蛋白通过作为细胞周期依赖性激酶（Cdks）的强效抑制剂，在调节细胞周期进展中发挥着关键作用，特别是针对几种G1细胞周期蛋白/细胞周期依赖性激酶复合物。这种调节对于维持正常的细胞分裂和防止不受控制的细胞增殖至关重要，否则会导致肿瘤形成。与p21 Waf1/Cip1家族的其他成员不同，p57 Kip2在细胞周期控制机制中独立于p53发挥作用。p57 Kip2能够阻止细胞进入G1期，这凸显了其在细胞对生长信号和压力的反应中的重要性，使p57 Kip2成为癌症生物学和治疗干预研究的重要焦点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p57 Kip2 抗体 (KP39) 参考文献:

  1. p57kip2在发育、分化和疾病过程中的转录调控。  |  Rossi, MN., et al. 2018. Front Biosci (Landmark Ed). 23: 83-108. PMID: 28930539
  2. p57Kip2决定了胃首领细胞的储备干细胞状态。  |  Lee, JH., et al. 2022. Cell Stem Cell. 29: 826-839.e9. PMID: 35523142
  3. p57Kip2作为转录核心抑制因子调控肠干细胞的命运和增殖  |  Creff, J., et al. 2023. Cell Rep. 42: 112659. PMID: 37327110
  4. 克隆具有独特结构域和组织分布的细胞周期蛋白依赖性激酶抑制因子 p57KIP2。  |  Lee, MH., et al. 1995. Genes Dev. 9: 639-49. PMID: 7729683
  5. p57KIP2 是 p21CIP1 Cdk 抑制剂家族中一个结构独特的成员，是一个候选肿瘤抑制基因。  |  Matsuoka, S., et al. 1995. Genes Dev. 9: 650-62. PMID: 7729684
  6. p15INK4B 是 TGF-beta 诱导的细胞周期停滞的潜在效应因子。  |  Hannon, GJ. and Beach, D. 1994. Nature. 371: 257-61. PMID: 8078588
  7. 一种受细胞周期调控的细胞周期蛋白依赖性激酶抑制剂。  |  Hengst, L., et al. 1994. Proc Natl Acad Sci U S A. 91: 5291-5. PMID: 8202483
  8. WAF1，p53 抑制肿瘤的潜在媒介。  |  el-Deiry, WS., et al. 1993. Cell. 75: 817-25. PMID: 8242752
  9. p21 是一种通用的细胞周期蛋白激酶抑制剂。  |  Xiong, Y., et al. 1993. Nature. 366: 701-4. PMID: 8259214
  10. 细胞周期控制中的一种新的调节基因，可对细胞周期蛋白 D/CDK4 产生特异性抑制作用。  |  Serrano, M., et al. 1993. Nature. 366: 704-7. PMID: 8259215
  11. p27Kip1是一种细胞周期蛋白-Cdk抑制剂，它将转化生长因子-β和接触抑制与细胞周期停滞联系在一起。  |  Polyak, K., et al. 1994. Genes Dev. 8: 9-22. PMID: 8288131
  12. 哺乳动物 G1 细胞周期蛋白  |  Sherr, CJ. 1993. Cell. 73: 1059-65. PMID: 8513492

订购信息

产品名称产品编号规格价格数量收藏夹

p57 Kip2 抗体 (KP39)

sc-56341
200 µg/ml
RMB2377.00

p57 Kip2 (KP39): m-IgG Fc BP-HRP 套装

sc-525656
200 µg Ab; 10 µg BP
RMB2662.00

p57 Kip2 (KP39): m-IgG2b BP-HRP 套装

sc-549608
200 µg Ab; 10 µg BP
RMB2662.00

p57 Kip2 抗体 (KP39) AC

sc-56341 AC
500 µg/ml, 25% agarose
RMB3129.00

p57 Kip2 抗体 (KP39) HRP

sc-56341 HRP
200 µg/ml
RMB2377.00

p57 Kip2 抗体 (KP39) FITC

sc-56341 FITC
200 µg/ml
RMB2482.00

p57 Kip2 抗体 (KP39) PE

sc-56341 PE
200 µg/ml
RMB2580.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 488

sc-56341 AF488
200 µg/ml
RMB2685.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 546

sc-56341 AF546
200 µg/ml
RMB2685.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 594

sc-56341 AF594
200 µg/ml
RMB2685.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 647

sc-56341 AF647
200 µg/ml
RMB2685.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 680

sc-56341 AF680
200 µg/ml
RMB2685.00

p57 Kip2 抗体 (KP39) Alexa Fluor® 790

sc-56341 AF790
200 µg/ml
RMB2685.00

The representative picture of western blot shows non-57 kDa size band in the page (https://www.scbt.com/ja/p/p57-antibody-kp39). Why the size are not 57kDa? One of the pictures shows more than two bands. What are those bands? Thanks.

Asked by: ISSS
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with p57 (KP39): sc-56341 monoclonal antibody?

Asked by: TinTin
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 13
Date published: 2017-02-08
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Rated 5 out of 5 by from Strong staining in IHC-PObtained strong signal in mouse podocyte in FFPE kidney tissue.
Date published: 2022-09-01
Rated 4 out of 5 by from working good!This antibody shows good results in IHC for mouse samples.
Date published: 2021-10-15
Rated 5 out of 5 by from Really good in western blotThe antibody was tested on whole lysates of Saos, Jurkat cell line and on human primary articular chondrocytes lysates. On chondrocytes lysates the band was defined and with high signal. The MW observed is around 57kDa.
Date published: 2018-12-13
Rated 5 out of 5 by from Molto soddisfacente in western blotL'anticorpo mostra un buon segnale in western blot su lisati di condrociti articolari umani di controllo e trattati con LiCl (5uM) (lane 2-3). Un segnale più debole si osserva in lisati di Jurkat (100kcells) (lane 4) . Molto specifico, buona reattività. Peso osservato circa 55kDa (banda compresa tra 50kDa e 60kDa).
Date published: 2018-12-11
Rated 2 out of 5 by from The antibody specificity is not good.Previous study has shown that p57 expression is restricted to the ventricular trabecular myocardium, but the immunofluorescence image shows that p57 expression in endothelium and epicardium.
Date published: 2017-11-01
Rated 3 out of 5 by from Not quite suitable for wb of rat protein1:200 diluted for wb of rat protein ,the band is not quite strong.
Date published: 2017-08-16
Rated 5 out of 5 by from Strong staining, low backgroundTested this antibody on formalin fixed mouse tissue using various antigen retrieval buffers. Antibody works very well and is comparable to antibody H-91 that this antibody replaces.
Date published: 2017-05-08
Rated 5 out of 5 by from Will give you strong bandsThis is a great p57 antibody. It reacts with mouse, rat, and human and will provide great results in standard lab applications. It has been published with several times.
Date published: 2017-01-18
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p57 Kip2 抗体 (KP39) is rated 4.5 out of 5 by 13.
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