Date published: 2026-10-19

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p38 alpha MAPK14 Antibody (27) - Western Blotting - Image 127545
p38α MAPK14 (27): sc-136210. 对 Jurkat 全细胞裂解液中 p38α MAPK14 的表达进行 Western 印迹分析.
p38 alpha MAPK14 Antibody (27) - Western Blotting - Image 127545
p38α MAPK14 (27): sc-136210. 对 Jurkat 全细胞裂解液中 p38α MAPK14 的表达进行 Western 印迹分析.
p38α MAPK14 (27): sc-136210. 对 Jurkat 全细胞裂解液中 p38α MAPK14 的表达进行 Western 印迹分析.

p38 alpha MAPK14 抗体 (27): sc-136210

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说明书
  • p38 alpha MAPK14 抗体 27 是小鼠单克隆 IgG1, 在15篇文献中引用，提供 50 µg/0.5 ml
  • 免疫human物种的p38α的氨基酸243-355
  • 推荐用于 mouse, rat, human 和 canine 来源的p38 alpha MAPK14 WB, IP 和 IF检测
  • 看 p38 alpha/beta MAPK (A-12): sc-7972，可查看有标记的 p38 alpha MAPK14 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成p38 alpha MAPK14 抗体 (27)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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附加p38 MAPK抗体，包括p38 alpha MAPK14, p38 beta MAPK11和p38 gamma MAPK12

MAP（丝裂原活化蛋白）激酶在许多生物学过程中发挥着重要作用，包括细胞粘附和扩散、细胞分化和凋亡。p38α、p38β和p38γ（分别称为MAPK14、MAPK11和MAPK12）各包含一个蛋白激酶结构域，属于MAP激酶家族。这些蛋白在体内不同部位表达，在心脏中有共同的表达模式，p38蛋白使用镁作为辅因子来催化ATP依赖性的靶蛋白磷酸化。通过其催化活性，p38α、p38β和p38γ参与细胞内的多种事件，包括信号转导途径、细胞因子产生以及细胞增殖和分化。p38蛋白在Thr和Tyr残基上发生磷酸化，这一事件被认为可以激活磷酸化蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p38 alpha MAPK14 抗体 (27) 参考文献:

  1. Mxi2 可促进与刺激无关的 ERK 核转位。  |  Casar, B., et al. 2007. EMBO J. 26: 635-46. PMID: 17255949
  2. MAPK p38α的三维对接。  |  Goldsmith, EJ. 2011. Sci Signal. 4: pe47. PMID: 22375047
  3. 基于咪唑骨架的p38α MAP激酶抑制剂作为抗炎剂的最新进展。  |  Kong, TT., et al. 2013. Curr Med Chem. 20: 1997-2016. PMID: 23317165
  4. p38α调节SERCA2a功能。  |  Kaikkonen, L., et al. 2014. J Mol Cell Cardiol. 67: 86-93. PMID: 24361238
  5. 整合非免疫细胞中的p38α MAPK免疫信号。  |  Gaffen, SL. and McGeachy, MJ. 2015. Sci Signal. 8: fs5. PMID: 25737584
  6. 酶促修饰的低密度脂蛋白刺激的人单核细胞中选择性p38α MAP激酶/MAPK14抑制：对动脉粥样硬化的影响。  |  Cheng, F., et al. 2017. FASEB J. 31: 674-686. PMID: 27871059
  7. 通过破坏胶质母细胞瘤中p38α-MAPK信号的稳定性，靶向ARNT可降低化疗耐药性。  |  Alafate, W., et al. 2024. Cell Death Dis. 15: 366. PMID: 38806469
  8. 鉴定丝裂原活化蛋白（MAP）激酶活化蛋白激酶-3--CSBP p38 MAP 激酶的新型底物。  |  McLaughlin, MM., et al. 1996. J Biol Chem. 271: 8488-92. PMID: 8626550
  9. 细胞对亚砷酸反应时，ERK、JNK/SAPK和P38/CSBP/RK map激酶家族成员的不同激活。  |  Liu, Y., et al. 1996. Free Radic Biol Med. 21: 771-81. PMID: 8902523
  10. 嘧啶基咪唑类CSBP/p38激酶抑制剂对肝细胞色素P450酶的抑制作用减弱。  |  Adams, JL., et al. 1998. Bioorg Med Chem Lett. 8: 3111-6. PMID: 9873686

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产品名称产品编号规格价格数量收藏夹

p38 alpha MAPK14 抗体 (27)

sc-136210
50 µg/0.5 ml
CNY2422.00

What is the recommended fixation method for immunofluorescence staining with p38α (27): sc-136210 monoclonal antibody?

Asked by: jerojero
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by Vasco from Very strong signalAntibody works really well. 20 µg of protein loaded and a very strong signal with a 1:1000 dilution of the antibody.
Date published: 2018-12-21
Rated 5 out of 5 by snowy from specific signalSignal not as strong as against human but still very good, non-specific bands are light and do not interfere with specific band
Date published: 2017-02-12
Rated 5 out of 5 by jjhou from GOOD antibodyI recommend this antibody!! The antibody was able to detect endogenous protein with WB in 293T, HELA whole cell lysates.I used it at a dilution of 1:500 for WB, and the results were great!
Date published: 2016-12-07
Rated 5 out of 5 by MS from Great WB data obtained using Jurkat wholeGreat WB data obtained using Jurkat whole cell lysate. -SCBT QC
Date published: 2015-03-16
Rated 5 out of 5 by JL from Good WB publishable data gathered with mouseGood WB publishable data gathered with mouse leukemic monocytic macrophage cell line. -SCBT Publication Review
Date published: 2014-12-08
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p38 alpha MAPK14 抗体 (27) is rated 5.0 out of 5 by 5.
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