Date published: 2025-9-6

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P2X3 抗体 (B-5): sc-390572

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说明书
  • P2X3 抗体 B-5 是小鼠单克隆 IgG1 κ,P2X3抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列338-397位于human物种的P2X3的C-terminus
  • P2X3 抗体 (B-5) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 P2X3
  • 抗P2X3抗体(B-5)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取P2X3 (B-5): sc-390572免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是P2X3 Antibody (B-5) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与P2X3 Antibody (B-5) 搭配使用(请参阅下面的订购信息)。

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関連項目

P2X3抗体(B-5)是一种IgG1 κ小鼠单克隆P2X3抗体(也被称为P2RX3抗体),它可以通过WB, IP, IF 和 ELISA检测小鼠、大鼠和人类来源的P2X3蛋白。P2X3抗体(B-5)既可以作为非偶联的P2X3抗体形式提供,也可以作为多种偶联形式的P2X3抗体提供,包括琼脂糖、辣根过氧化物酶、藻红蛋白、异硫氰酸荧光素和多种Alexa Fluor®偶联物。P2X受体家族由配体门控离子通道组成,这些通道响应细胞外ATP而增加钙离子进入细胞的通透性。七个P2X受体,即P2X1-P2X7,可以形成同聚体或异聚体通道,或同时形成两种通道。它们的特征是细胞内具有氨基和羧基末端。P2X受体在多种组织中表达,包括神经元、前列腺、膀胱、胰腺、结肠、睾丸和卵巢。P2X受体的主要功能是通过结合作为神经递质的细胞外ATP来介导神经元之间以及神经元与其他组织之间的突触传递。在长时间暴露于高浓度的细胞外ATP后,P2X受体可能参与坏死或凋亡的发生。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

P2X3 抗体 (B-5) 参考文献:

  1. 细胞溶解 P2X 嘌呤受体。  |  Di Virgilio, F., et al. 1998. Cell Death Differ. 5: 191-9. PMID: 10200464
  2. 西巴克隆蓝对人类 P2X(3)受体的异构调节和加速再敏化。  |  Alexander, K., et al. 1999. J Pharmacol Exp Ther. 291: 1135-42. PMID: 10565834
  3. 二价阳离子对 P2X2 嘌呤受体的失活作用。  |  Ding, S. and Sachs, F. 2000. J Physiol. 522 Pt 2: 199-214. PMID: 10639098
  4. 大鼠视网膜 Müller 细胞中含有 P2X(3), P2X(4), P2X(5) 而非 P2X(7) 嘌呤能受体的证据  |  Jabs, R., et al. 2000. Brain Res Mol Brain Res. 76: 205-10. PMID: 10762695
  5. 因缺失一个氨基酸残基而形成的天然显性阴性 P2X1 受体。  |  Oury, C., et al. 2000. J Biol Chem. 275: 22611-4. PMID: 10816552
  6. 感觉神经元中的 P2X 受体  |  Burnstock, G. 2000. Br J Anaesth. 84: 476-88. PMID: 10823099
  7. 克隆 P2X 受体的药理学。  |  North, RA. and Surprenant, A. 2000. Annu Rev Pharmacol Toxicol. 40: 563-80. PMID: 10836147
  8. P2X3 和 P2X2/3 受体拮抗剂。  |  Bölcskei, H. and Farkas, B. 2014. Pharm Pat Anal. 3: 53-64. PMID: 24354979
  9. 将含 P2X3 受体作为治疗慢性疼痛的靶点  |  Krajewski, JL. 2020. Neurotherapeutics. 17: 826-838. PMID: 33009633
  10. 通过对 P2X3 的异构调节缓解慢性咳嗽,且无味觉干扰。  |  Guo, CR., et al. 2023. Nat Commun. 14: 5844. PMID: 37730705
  11. 治疗神经源性疾病的新型 P2X3 抑制剂。  |  Sabnis, RW. 2023. ACS Med Chem Lett. 14: 1146-1147. PMID: 37736194
  12. 人类 P2x1 受体:分子克隆, 组织分布和 17 号染色体定位。  |  Longhurst, PA., et al. 1996. Biochim Biophys Acta. 1308: 185-8. PMID: 8809107

订购信息

产品名称产品编号规格价格数量收藏夹

P2X3 抗体 (B-5)

sc-390572
200 µg/ml
RMB2377.00

P2X3 (B-5): m-IgG Fc BP-HRP 套装

sc-526173
200 µg Ab; 10 µg BP
RMB2662.00

P2X3 抗体 (B-5) AC

sc-390572 AC
500 µg/ml, 25% agarose
RMB3129.00

P2X3 抗体 (B-5) HRP

sc-390572 HRP
200 µg/ml
RMB2377.00

P2X3 抗体 (B-5) FITC

sc-390572 FITC
200 µg/ml
RMB2482.00

P2X3 抗体 (B-5) PE

sc-390572 PE
200 µg/ml
RMB2580.00

P2X3 抗体 (B-5) Alexa Fluor® 488

sc-390572 AF488
200 µg/ml
RMB2685.00

P2X3 抗体 (B-5) Alexa Fluor® 546

sc-390572 AF546
200 µg/ml
RMB2685.00

P2X3 抗体 (B-5) Alexa Fluor® 594

sc-390572 AF594
200 µg/ml
RMB2685.00

P2X3 抗体 (B-5) Alexa Fluor® 647

sc-390572 AF647
200 µg/ml
RMB2685.00

P2X3 抗体 (B-5) Alexa Fluor® 680

sc-390572 AF680
200 µg/ml
RMB2685.00

P2X3 抗体 (B-5) Alexa Fluor® 790

sc-390572 AF790
200 µg/ml
RMB2685.00

We tested the P2X3 (B-5, sc-390572) mouse monoclonal antibody in Western blots with mouse dorsal root ganglion tissue. Unfortunately there is only unpsecific band from secondary antibody (anti-mouse-IgG1 680, Licor). We didn´t detect band aroud 43 kDa.

Asked by: Ruirui Lu
Thank you for your question. Please contact our Technical Service Department and we would be happy to help you troubleshoot the antibody. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-11-02

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-390572: P2X3 (B-5) mouse monoclonal antibody will work?

Asked by: DefinitelyNotMatt
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Versatile AntibodyThis antibody is well-cited for a variety of applications including WB, IP, IF, and even ELISA. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-27
Rated 5 out of 5 by from Nice Western Blot data of P2X3 expression in RTNice Western Blot data of P2X3 expression in RT-4 whole cell lysate. -SCBT QC
Date published: 2015-04-03
Rated 5 out of 5 by from Produced positive Western Blot data of P2X3Produced positive Western Blot data of P2X3 expression in T24 and Hep G2 whole cell lysates. -SCBT QC
Date published: 2014-08-18
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P2X3 抗体 (B-5) is rated 5.0 out of 5 by 3.
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