Date published: 2025-9-8
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p-Ribosomal Protein S6 Antibody (B-6) - Western Blotting - Image 354437
核糖体蛋白 S6 抗体 (B-6): sc-514033. 核糖体蛋白 S6 磷酸化在 Hep G2 (A), K-562 (B) 和 CCRF-CEM (C) 全细胞裂解液中的 Western 印迹分析.
核糖体蛋白 S6 抗体 (B-6): sc-514033. 核糖体蛋白 S6 磷酸化在 Hep G2 (A), K-562 (B) 和 CCRF-CEM (C) 全细胞裂解液中的 Western 印迹分析.

p-Ribosomal Protein S6 抗体 (B-6): sc-514033

2.8(6)
寫評論提問

说明书
  • p-Ribosomal Protein S6抗体(B-6)是小鼠单克隆IgM κ, 在2篇文献中引用，规格为200 µg/ml
  • 特异性表位，对应于含有磷酸化丝氨酸236的短氨基酸序列，来源于Ribosomal Protein S6的human
  • 推荐用于 mouse, rat 和 human 来源的Ser 236 phosphorylated 40S Ribosomal Protein S6 WB, IP, IF 和 ELISA检测
  • 关于如何获取p-Ribosomal Protein S6 (B-6): sc-514033的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成p-Ribosomal Protein S6 抗体 (B-6)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Ribosomal Protein 抗体 包括 Ribosomal Protein L11, Ribosomal Protein L13, Ribosomal Protein L14, Ribosomal Protein L17, Ribosomal Protein L18, Ribosomal Protein L19, Ribosomal Protein L21, Ribosomal Protein L22, Ribosomal Protein L23a和Ribosomal Protein L30

p-核糖体蛋白S6抗体（B-6）是一种IgM κ小鼠单克隆p-核糖体蛋白S6抗体（也称为p-核糖体蛋白S6抗体或RPS6抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的Ser 236磷酸化的40S核糖体蛋白S6。p-核糖体蛋白S6抗体（B-6）可作为非偶联抗p-核糖体蛋白S6抗体形式使用。编码哺乳动物核糖体蛋白的基因由多基因家族组成，这些基因家族主要由多个加工过的假基因和一个功能性的内含子基因组成。RPS6基因产生核糖体蛋白S6（也称为RPS6）。RPS6是真核核糖体中蛋白激酶的主要底物。序列比较已确定RPS6与酿酒酵母的核糖体蛋白S10相当。来自进化上遥远的真核生物（如酵母和人类）的核糖体蛋白的序列比较表明，RPS6的结构和可能的功能高度保守。RPS6磷酸化受生长因子、肿瘤促进剂和有丝分裂原的刺激。它在生长停滞时被去磷酸化。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-Ribosomal Protein S6 抗体 (B-6) 参考文献:

  1. 静止盐水虾胚胎在进入出芽前发育时，S6激酶活性被激活，表现为p70核糖体蛋白S6激酶：分离Artemia franciscana p70S6k cDNA。  |  Santiago, J. and Sturgill, TW. 2001. Biochem Cell Biol. 79: 141-52. PMID: 11310561
  2. 瘦素受体的长链通过替代机制调节STAT5和核糖体蛋白S6。  |  Gong, Y., et al. 2007. J Biol Chem. 282: 31019-27. PMID: 17726024
  3. 通过杆状病毒介导的表达、纯化和表征，构建了70 kDa 40S核糖体蛋白S6激酶-1αII亚型（S6K1αII）的完全激活催化激酶结构域。  |  Keshwani, MM., et al. 2008. Protein Expr Purif. 58: 32-41. PMID: 18160308
  4. 磷酸化核糖体蛋白 S6 在食管鳞状细胞癌中的预后意义和功能  |  Kim, SH., et al. 2013. Mod Pathol. 26: 327-35. PMID: 22996377
  5. 磷酸化核糖体蛋白S6是Akt驱动的增生和恶性转化所必需的，但不是胰腺β细胞肥大、非整倍性和功能亢进所必需的。  |  Wittenberg, AD., et al. 2016. PLoS One. 11: e0149995. PMID: 26919188
  6. 磷酸化核糖体蛋白S6与口腔鳞状细胞癌中p21表达相关，与肿瘤大小呈负相关。  |  de Vicente, JC., et al. 2017. Head Neck. 39: 1876-1887. PMID: 28675642
  7. IL-7疗法对接受抗逆转录病毒治疗的患者中HIV特异性CD8 T细胞中磷酸化核糖体蛋白S6和TRAF1表达的影响。  |  Wang, C., et al. 2018. J Immunol. 200: 558-564. PMID: 29222166
  8. 死后人脑核糖体蛋白 S6 功能减退将 mTORC1 依赖性信号传导与精神分裂症联系起来  |  Ibarra-Lecue, I., et al. 2020. Front Pharmacol. 11: 344. PMID: 32265715
  9. 间皮瘤患者中磷酸化核糖体蛋白S6的表达--与临床病理特征和结果相关：欧洲胸腔肿瘤平台（ETOP）Mesoscape项目的结果。  |  Rüschoff, JH., et al. 2022. Mod Pathol. 35: 1888-1899. PMID: 36115922
  10. 研究CoAlation对核糖体蛋白S6激酶1的调节。  |  Malanchuk, O., et al. 2024. Int J Mol Sci. 25: PMID: 39201434

订购信息

产品名称产品编号规格价格数量收藏夹

p-Ribosomal Protein S6 抗体 (B-6)

sc-514033
200 µg/ml
RMB2377.00

p-Ribosomal Protein S6 (B-6) 中和勝肽

sc-514033 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-514033 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
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Rated 1 out of 5 by from no bandsUnfortunately i could not detect any bands in 3% milk/tbst using A549 cell lysates
Date published: 2021-03-17
Rated 2 out of 5 by from Antibody reviewNot much promising with western blotting at 1:500 dilution.
Date published: 2017-09-27
Rated 1 out of 5 by from No signalI used this antibody repeatedly in western blot on endogenous proteins of CRC cell lines and don't get any signal.
Date published: 2017-09-25
Rated 4 out of 5 by from a good antibody for WBThis antibody recognizes a band of predicted molecular weight (1:500 dilution, 30 ug HeLa total extract), although the signal intensity is somewhat low.
Date published: 2017-08-24
Rated 4 out of 5 by from goodworked well in wb, the band is great ,but the backgound is not very perfect ,not very clean
Date published: 2017-03-07
Rated 5 out of 5 by from Worked well for WB with untreated HEK293 and EGFWorked well for WB with untreated HEK293 and EGF-treated HEK293 whole cell lysates. -SCBT QC
Date published: 2013-09-03
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p-Ribosomal Protein S6 抗体 (B-6) is rated 2.8 out of 5 by 6.
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