Date published: 2025-9-6
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p-PKC zeta Antibody (H-2) - Immunohistochemistry - Image 350577
p-PKC ζ (H-2): sc-271962. 对福尔马林固定, 石蜡包埋的人类前列腺组织进行免疫过氧化物酶染色, 显示腺细胞, 间质细胞和平滑肌细胞的胞浆染色.
p-PKC ζ (H-2): sc-271962. 对福尔马林固定, 石蜡包埋的人类前列腺组织进行免疫过氧化物酶染色, 显示腺细胞, 间质细胞和平滑肌细胞的胞浆染色.

p-PKC zeta 抗体 (H-2): sc-271962

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寫評論提問

说明书
  • p-PKC zeta抗体(H-2)是小鼠单克隆IgG1 κ, 在11篇文献中引用，规格为200 µg/ml
  • 抗-p-PKC zeta 抗体 (H-2) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Thr 410 phosphorylated PKC ζ
  • 抗p-PKC zeta抗体（H-2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取p-PKC zeta (H-2): sc-271962的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 p-PKC zeta 抗体 (H-2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与p-PKC zeta 抗体 (H-2) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
说明书与实验方案
研究信息

関連項目

此外 PKC 抗体包括 PKC α, PKC β, PKC δ, PKC ε, PKC η, PKC γ, PKC ι, PKC λ, PKC μ 和 PKC ν

p-PKC ζ抗体（H-2）是一种IgG1 κ小鼠单克隆p-PKC ζ抗体（也称为PKC ζ抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的Thr 410磷酸化PKC ζ。p-PKC ζ抗体（H-2）既可作为非偶联抗p-PKC ζ抗体形式提供，也可作为多种偶联形式的抗p-PKC ζ抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。蛋白激酶C（PKC）家族的成员在多种细胞功能中发挥关键的调节作用，包括细胞生长和分化、基因表达、激素分泌和膜功能。PKC最初被鉴定为丝氨酸/苏氨酸蛋白激酶，其活性依赖于钙和磷脂。二酰甘油（DAG）和促肿瘤佛波酯与PKC结合并激活PKC。PKC至少可分为两大类，包括常规（c）PKC异构体（α、βI、βII和γ）和新型（n）PKC异构体（δ、ε、ζ、η和θ）。在Thr 507磷酸化后，PKC δ被激活，它可以抑制特定底物的功能，如Jak2和Stat3。IL-6诱导后，PKC δ在Ser 727上磷酸化并与Stat3结合，从而负调控Stat3的DNA结合和转录活性。PKC ζ的磷酸化由PDK1诱导。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-PKC zeta 抗体 (H-2) 参考文献:

  1. 蛋白激酶 C delta 以白细胞介素-6 依赖性方式与 Stat3 结合并使其磷酸化。  |  Jain, N., et al. 1999. J Biol Chem. 274: 24392-400. PMID: 10446219
  2. IL-3 依赖性髓系祖细胞巨噬细胞分化过程中蛋白激酶 C 对 Jak2 酪氨酸激酶的调控  |  Kovanen, PE., et al. 2000. Blood. 95: 1626-32. PMID: 10688817
  3. 噻唑烷二酮治疗可增强胰岛素对非糖尿病和后藤柿崎 II 型糖尿病大鼠脂肪细胞中蛋白激酶 C-zeta /lambda 活化和葡萄糖转运的影响。  |  Kanoh, Y., et al. 2000. J Biol Chem. 275: 16690-6. PMID: 10749857
  4. 蛋白激酶 C 家族的新成员 nPKC theta 主要在骨骼肌中表达。  |  Osada, S., et al. 1992. Mol Cell Biol. 12: 3930-8. PMID: 1508194
  5. [正常眼睛和青光眼中的视网膜神经纤维层。I. 398 例青光眼患者的半定量数据]。  |  Jonas, JB., et al. 1989. Klin Monbl Augenheilkd. 194: 437-46. PMID: 2761192
  6. 膜磷脂对多功能蛋白激酶的钙依赖性激活。  |  Takai, Y., et al. 1979. J Biol Chem. 254: 3692-5. PMID: 438153
  7. 肌醇磷脂的周转和信号转导  |  Nishizuka, Y. 1984. Science. 225: 1365-70. PMID: 6147898
  8. 蛋白激酶 C 在细胞表面信号转导和肿瘤促进中的作用。  |  Nishizuka, Y. Nature. 308: 693-8. PMID: 6232463
  9. 蛋白激酶 C 可能是促进肿瘤生长的植物醇酯的受体蛋白。  |  Kikkawa, U., et al. 1983. J Biol Chem. 258: 11442-5. PMID: 6311812
  10. 促进肿瘤生长的植物醇酯直接激活钙激活的磷脂依赖性蛋白激酶。  |  Castagna, M., et al. 1982. J Biol Chem. 257: 7847-51. PMID: 7085651

订购信息

产品名称产品编号规格价格数量收藏夹

p-PKC zeta 抗体 (H-2)

sc-271962
200 µg/ml
RMB2377.00

p-PKC zeta (H-2): m-IgG Fc BP-HRP 套装

sc-525840
200 µg Ab; 10 µg BP
RMB2662.00

p-PKC zeta 抗体 (H-2) AC

sc-271962 AC
500 µg/ml, 25% agarose
RMB3129.00

p-PKC zeta 抗体 (H-2) HRP

sc-271962 HRP
200 µg/ml
RMB2377.00

p-PKC zeta 抗体 (H-2) FITC

sc-271962 FITC
200 µg/ml
RMB2482.00

p-PKC zeta 抗体 (H-2) PE

sc-271962 PE
200 µg/ml
RMB2580.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 488

sc-271962 AF488
200 µg/ml
RMB2685.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 546

sc-271962 AF546
200 µg/ml
RMB2685.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 594

sc-271962 AF594
200 µg/ml
RMB2685.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 647

sc-271962 AF647
200 µg/ml
RMB2685.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 680

sc-271962 AF680
200 µg/ml
RMB2685.00

p-PKC zeta 抗体 (H-2) Alexa Fluor® 790

sc-271962 AF790
200 µg/ml
RMB2685.00

p-PKC zeta (H-2) 中和勝肽

sc-271962 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-271962 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from good antibody for wbThe antibody was used in different cell lines at the concentration of 1:500 diluted in TBS 0,1% Tween-20 and used for 2 hours or overnight. The signal is clear and specific.
Date published: 2021-10-04
Rated 4 out of 5 by from WBI used this antibody for WB. I could detect clear bands.
Date published: 2021-01-05
Rated 5 out of 5 by from satisfied with the antibodyThe WB strong signal can be obtained in the sample of rats that dilute 1/500 with the antibody
Date published: 2017-10-20
Rated 5 out of 5 by from Great productWe used this antibody for our western blot. give us good results.
Date published: 2017-09-27
Rated 5 out of 5 by from 值得拥有SC是实验室的常备抗体，4度保存，方便使用，本次希望加入Cruzcredits计划，更多的体验，满心期待。
Date published: 2017-07-27
Rated 5 out of 5 by from Excellent!This antibody works great in immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of glandular cells, interstitial cells and smooth muscle cells.
Date published: 2017-01-19
Rated 5 out of 5 by from PraiseUsed at 1:500 dilution in human epidermoid cancer and prostate cancer 293T cell lysates,and get a good signal.
Date published: 2016-12-17
Rated 5 out of 5 by from This antibody works great in IF in mouse cellsThis antibody works great in IF in mouse cells.
Date published: 2015-10-05
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p-PKC zeta 抗体 (H-2) is rated 4.7 out of 5 by 10.
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