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p-JNK 抗体 (9H8): sc-81502

4.8(4)
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说明书
  • p-JNK 抗体 9H8 是小鼠单克隆 IgG1, 在38篇文献中引用，提供 50 µg/0.5 ml
  • 针对磷酸化肽段，与JNK的pThr-Gly/Pro-pTyr基序周围的氨基酸残基对应，human来源
  • 推荐用于 mouse, rat 和 human 来源的both Tyr 185 phosphorylated JNK1, JNK2 and JNK3 and Thr 183 and Tyr 185 dually phosphorylated JNK1, JNK2 and JNK3 WB, IP, IF 和 ELISA检测; 与non-phosphorylated form of JNK不交叉反应
  • 看 p-JNK (G-7): sc-6254，可查看有标记的 p-JNK 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成p-JNK 抗体 (9H8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 JNK 抗体包括 JNK1, JNK2 和 JNK3

丝裂原活化蛋白（MAP）激酶ERK 1和ERK 2是脯氨酸定向激酶，它们通过酪氨酸和苏氨酸残基的同时磷酸化而被激活。JNK家族包括JNK1、JNK2和JNK3，与MAP激酶家族有远亲关系，其成员在Thr-Pro-Tyr基序上的Thr 183和Tyr 185残基处通过双重磷酸化被激活，以响应紫外（UV）光。这一基序与MAP激酶家族的Thr-Glu-Tyr基序不同。JNK被JNK激活激酶（JNKK1和JNKK2）磷酸化，它们是MEK家族的成员。活化的JNK介导c-Jun在氨基末端丝氨酸调控位点Ser 63和Ser 73处的磷酸化，这刺激了c-Jun的反式激活功能。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-JNK 抗体 (9H8) 参考文献:

  1. 蛋白激酶p-JNK与肝细胞癌中AP-1及其相关Jun家族蛋白的活化有关。  |  Guo, L., et al. 2005. Life Sci. 77: 1869-78. PMID: 15927205
  2. NaF通过p-ERK和p-JNK诱导LS8细胞凋亡--氟斑牙的机制研究。  |  Zhao, L., et al. 2016. Acta Odontol Scand. 74: 539-549. PMID: 27624793
  3. 氨溴索通过抑制 p-JNK/p-ERK 减轻顺铂诱导的肝毒性和肾毒性。  |  Bishr, A., et al. 2019. Can J Physiol Pharmacol. 97: 55-64. PMID: 30383980
  4. 抑制 p-mTOR 可通过降低 p-JNK 抑制 PS1 的转录  |  Das, HK. and Hontiveros, SS. 2020. Front Biosci (Landmark Ed). 25: 1297-1304. PMID: 32114433
  5. CAB39 通过上调 p-JNK 促进鼻咽癌 CNE-1 细胞增殖  |  Peng, L., et al. 2020. Cancer Manag Res. 12: 11203-11209. PMID: 33177871
  6. 抗炎二肽--一种来自安比奥巴分泌物的代谢产物--通过阻断 p-JNK/Bax 通路的细胞凋亡保护脑缺血损伤。  |  Zhang, Q., et al. 2021. Front Pharmacol. 12: 689007. PMID: 34220513
  7. [电针对脑外伤大鼠神经功能及 p-JNK 和 Beclin-1 表达的影响］  |  Liu, RC., et al. 2023. Zhen Ci Yan Jiu. 48: 475-80. PMID: 37247861
  8. 线粒体 P-JNK 靶标 SAB（SH3BP5）在细胞死亡调控中的作用。  |  Win, S., et al. 2024. Front Cell Dev Biol. 12: 1359152. PMID: 38559813
  9. 更正： RacGAP1通过miR-192和p-JNK调节AP-1，从而促进宫颈癌的恶性进展。  |  Zhang, T., et al. 2024. Cell Death Dis. 15: 528. PMID: 39048575
  10. 维生素 B6 通过 p-JNK/Nrf-2/NF-κB 信号改善氯化镉诱导的氧化应激介导的小鼠海马记忆缺陷  |  Nasir, A., et al. 2024. Curr Neuropharmacol.. PMID: 39092643

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产品名称产品编号规格价格数量收藏夹

p-JNK 抗体 (9H8)

sc-81502
50 µg/0.5 ml
RMB2377.00

请问有试用装吗，有10ul的包装吗

Asked by: Anonymous
感谢您提问。 我们公司绝大多数一抗抗体都有小样提供，小样需要随正装的订单赠送。 p-JNK 抗体 (9H8): sc-81502目前没有小样提供，同靶标的sc-6254有小样提供。 https://www.scbt.com/p/p-jnk-antibody-g-7 Thank you for your question. Most of our primary antibodies are available as samples, which need to be gifted along with a full-sized product order. No sample is available for sc-81502 at present, and a sample is available for sc-6254 of the same target. https://www.scbt.com/p/p-jnk-antibody-g-7
Answered by: Ling Chen
Date published: 2024-11-19

I am using p-JNK (9H8): sc-81502 for immunofluorescence, what dilution of this antibody should I use?

Asked by: AbPolly
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from This antibody worked well in detecting pThis antibody worked well in detecting p-JNK in western blotting assay.
Date published: 2016-09-02
Rated 5 out of 5 by from WB: Positive in mouse L929 cellsWB: Positive in mouse L929 cells. -SCBT Publication Review
Date published: 2015-03-12
Rated 5 out of 5 by from Publication in IP and WB with human HeLa samplesPublication in IP and WB with human HeLa samples. -SCBT Publication Review
Date published: 2015-03-10
Rated 5 out of 5 by from Worked well for WesternWorked well for Western, publication in A549 cells. -SCBT Publication Review
Date published: 2014-02-17
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p-JNK 抗体 (9H8) is rated 4.8 out of 5 by 4.
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