Date published: 2025-9-7

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p-INSR/Insulin Receptor β 抗体 (10C3): sc-81500

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说明书
  • p-INSR/Insulin Receptor β 抗体 10C3 是小鼠单克隆 IgG1, 在41篇文献中引用,提供 50 µg/0.5 ml
  • 与human起源的insulin R的酪氨酸1150/1151周围的氨基酸残基对应的磷酸化肽段
  • 推荐用于 mouse, rat 和 human 来源的Tyr 1150 and Tyr 1151 dually phosphorylated insulin Rβ and IGF1 receptor WB 和 IP检测
  • 关于如何获取p-INSR/Insulin Receptor β (10C3): sc-81500免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是p-INSR/Insulin Receptor β Antibody (10C3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与p-INSR/Insulin Receptor β Antibody (10C3) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

p-insulin Rβ抗体(10C3)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)和免疫沉淀(IP)应用检测小鼠、大鼠和人类样本中的p-insulin Rβ 。p-insulin Rβ (10C3)抗体以非结合形式提供,专门用于检测胰岛素受体β亚基和IGF1受体的双磷酸化的Tyr 1150和Tyr 1151。胰岛素受体(IR)通过调节胰岛素的作用在细胞代谢中发挥关键作用,而胰岛素是维持血糖平衡的关键激素。胰岛素受体位于细胞膜上,是一种异二聚体蛋白复合物,由细胞外的α亚基和细胞内的β亚基组成,β亚基对于受体功能至关重要。胰岛素结合后,胰岛素受体会发生构象变化,激活内源性酪氨酸激酶活性,导致β亚基内特定酪氨酸残基的磷酸化。这种磷酸化过程有助于各种信号蛋白的聚集,从而传播胰岛素信号,最终促进目标组织中的葡萄糖摄取和糖原合成。人类胰岛素受体基因编码一种由1382个氨基酸组成的蛋白质,该蛋白质被切割成功能性α和β亚基,并经历翻译后修饰,例如在Tyr 1322处的磷酸化,这进一步调节了活性和信号传导能力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-INSR/Insulin Receptor β 抗体 (10C3) 参考文献:

  1. 通过胰岛素受体发出信号。  |  Whitehead, JP., et al. 2000. Curr Opin Cell Biol. 12: 222-8. PMID: 10712920
  2. 胰岛素受体:从蛋白质序列到结构。  |  Marino-Buslje, C., et al. 1999. Biochem Soc Trans. 27: 715-26. PMID: 10917671
  3. 跨膜信号传递机制:胰岛素结合与胰岛素受体。  |  Ottensmeyer, FP., et al. 2000. Biochemistry. 39: 12103-12. PMID: 11015187
  4. 胰岛素受体--结构和功能特征。  |  Perz, M. and Torlińska, T. 2001. Med Sci Monit. 7: 169-77. PMID: 11208515
  5. 胰岛素受体变异形式与 2 型糖尿病。  |  Sesti, G. 2000. Pharmacogenomics. 1: 49-61. PMID: 11258596
  6. 磷酸化胰岛素样生长因子-I/胰岛素受体存在于所有乳腺癌亚型中,与不良预后相关。  |  Law, JH., et al. 2008. Cancer Res. 68: 10238-46. PMID: 19074892
  7. 基质金属蛋白酶-7(MMP-7)和磷酸化胰岛素生长因子受体I(pIGF-1R)的共同表达与野生型KRAS患者接受西妥昔单抗或帕尼单抗治疗后的不良预后相关:GEMCAD研究。  |  Hörndler, C., et al. 2011. Cancer Biol Ther. 11: 177-83. PMID: 21099348
  8. 预测早产的宫颈磷酸化胰岛素样生长因子结合蛋白-1测试:系统评价和荟萃分析。  |  Conde-Agudelo, A. and Romero, R. 2016. Am J Obstet Gynecol. 214: 57-73. PMID: 26149828
  9. 晚期胃肠道间质瘤(GIST)中磷酸化胰岛素生长因子I受体(p-IGF1R)和金属蛋白酶-3(MMP3)的表达。GEIS 19研究。  |  Maurel, J., et al. 2016. Clin Sarcoma Res. 6: 10. PMID: 27358721
  10. ZFYVE28通过增加晚期内体产生来促进胰岛素受体磷酸化降解,从而介导胰岛素抵抗。  |  Yu, L., et al. 2023. Nat Commun. 14: 6833. PMID: 37884540

订购信息

产品名称产品编号规格价格数量收藏夹

p-INSR/Insulin Receptor β 抗体 (10C3)

sc-81500
50 µg/0.5 ml
RMB2377.00

p-INSR/Insulin Receptor β (10C3): m-IgGκ BP-HRP 套装

sc-534471
50 µg Ab; 40 µg BP
RMB2662.00

What are the components in our p-insulin Rβ (10C3): sc-81500 antibody solution?

Asked by: jenni
Each vial contains 50 µg IgG1 in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose.
Answered by: Technical Support 12
Date published: 2017-01-09
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Rated 5 out of 5 by from OutstandingVery clean highly specific signal; low background !!
Date published: 2017-01-07
Rated 5 out of 5 by from Excellent WB resultSaw increased expression in insulin stimulated MDA-MB-231 whole cell lysate as expected.
Date published: 2016-12-30
Rated 5 out of 5 by from Clean band in WB using insulin stimulated MDAClean band in WB using insulin stimulated MDA-MB-231 whole cell lysates. -SCBT Publication Review
Date published: 2015-04-24
Rated 5 out of 5 by from Published western blot data on human andPublished western blot data on human and murine hepatocytes. -SCBT Publication Review
Date published: 2015-01-20
Rated 4 out of 5 by from Successfully immunoprecipitated phosphoSuccessfully immunoprecipitated phospho-insulinR beta from murine brain slices. -SCBT Publication Review
Date published: 2015-01-17
Rated 5 out of 5 by from Worked well for immunoprecipitation and immunoblottingWorked well for immunoprecipitation and immunoblotting - used murine 3T3-L1/mesenchymal stem cell lysates. -SCBT QC
Date published: 2015-01-10
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p-INSR/Insulin Receptor β 抗体 (10C3) is rated 4.8 out of 5 by 6.
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