Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41. Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jap.J.Pharmacol. 41 393. Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266.
抑制剂:
Enzyme, 和 TXA Synthase.
物理状态 :
Solid
溶解度 :
Soluble in water (53 mg/ml at 25° C), DMSO (53 mg/ml at 25° C), and ethanol (6 mg/ml at 25° C).
保存 :
Store at room temperature
折射率 :
n20D 1.59 (Predicted)
IC50 :
thromboxane synthetase: IC50 = 4 nM; TXA2R: IC50 = >0.1 mM (human); Cavia porcellus: IC50 = >1 mM