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OX2R Antibody (OX110) - Flow Cytometry - Image 13794
OX2R 抗体 (OX110): sc-53103. 用 OX2R 抗体 (OX110) 染色的小鼠外周血白细胞的间接 FCM 分析, 然后用 PE 结合的山羊抗大鼠 IgG: sc-3740. 黑线直方图代表同型对照, 正常大鼠 IgG1: sc-3882.
OX2R Antibody (OX110) - Flow Cytometry - Image 13794
OX2R 抗体 (OX110): sc-53103. 用 OX2R 抗体 (OX110) 染色的小鼠外周血白细胞的间接 FCM 分析, 然后用 PE 结合的山羊抗大鼠 IgG: sc-3740. 黑线直方图代表同型对照, 正常大鼠 IgG1: sc-3882.
OX2R 抗体 (OX110): sc-53103. 用 OX2R 抗体 (OX110) 染色的小鼠外周血白细胞的间接 FCM 分析, 然后用 PE 结合的山羊抗大鼠 IgG: sc-3740. 黑线直方图代表同型对照, 正常大鼠 IgG1: sc-3882.

OX2R 抗体 (OX110): sc-53103

4.0(1)
寫評論提問
说明书
  • OX2R 抗体 OX110 是大鼠单克隆 IgG1，提供 200 µg/ml
  • 针对融合蛋白mCD200RCD4d3+4（mouse起源）
  • 推荐用于 mouse 来源的OX2R FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前，我们还没有完成OX2R 抗体 (OX110)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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    描述
    基因信息
    说明书与实验方案
    研究信息

    関連項目

    OX2抗体

    OX2（CD200，MOX2）是免疫球蛋白超家族（IgSF）的成员，是一种248残基的细胞表面糖蛋白，表达于淋巴细胞、神经元和内皮细胞。OX2受体（OX2R）是一种膜蛋白，其重量的70％来自N-链糖基化，主要表达于淋巴细胞和神经组织。将OX2R与其他白细胞IgSF糖蛋白进行系统发育分析表明，OXR2和OX2共享一个共同的祖先蛋白。OX2R的细胞质部分含有NPXY基序，这些基序已知可与PTB/PID结合结构域相互作用。OX2与OX2R之间的相互作用可能有助于抑制和限制组织中巨噬细胞诱导的炎症损伤的途径。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    OX2R 抗体 (OX110) 参考文献:

    1. OX2R激活诱导PKC介导的ERK和CREB磷酸化。  |  Guo, Y. and Feng, P. 2012. Exp Cell Res. 318: 2004-13. PMID: 22652455
    2. OX2R的C端显著影响下游信号通路。  |  Wang, C., et al. 2017. Mol Med Rep. 16: 159-166. PMID: 28487995
    3. 下丘脑素/食欲素受体药理学和睡眠阶段。  |  Sun, Y., et al. 2021. Front Neurol Neurosci. 45: 22-37. PMID: 34052813
    4. 改良的苏安唑仑汤通过调节Orexin-A和HPA轴稳态，对失眠小鼠模型产生镇静作用。  |  Dong, YJ., et al. 2021. Biomed Pharmacother. 143: 112141. PMID: 34509822
    5. 海马体食欲素受体：定位和功能。  |  Elahdadi Salmani, M., et al. 2022. Vitam Horm. 118: 393-421. PMID: 35180935
    6. 在嗜睡症小鼠模型中，OX2R选择性食欲素激动剂足以改善发作性睡病和睡眠/觉醒不连续，而不会诱发药物寻求行为。  |  Yamamoto, H., et al. 2022. PLoS One. 17: e0271901. PMID: 35867683
    7. 食欲素2受体选择性激动剂达那沃雷司通可改善小鼠模型和人类患者的发作性睡病表型。  |  Evans, R., et al. 2022. Proc Natl Acad Sci U S A. 119: e2207531119. PMID: 35994639
    8. 小鼠睾丸中Orexin B（OXB）及其2型受体（OX2R）在出生后发育过程中的定位和表达。  |  Yadav, A., et al. 2023. Peptides. 164: 170979. PMID: 36841281
    9. TAK-994是一种新型口服脑渗透性奥列克辛2受体选择性激动剂，可抑制小鼠发作性睡病模型的清醒状态和发作性睡病样发作的片段化。  |  Ishikawa, T., et al. 2023. J Pharmacol Exp Ther. 385: 193-204. PMID: 37001988
    10. OX2R激动剂对小鼠大脑中tau蛋白迁移和清除的影响。  |  Terada, M., et al. 2024. Sci Rep. 14: 15964. PMID: 38987562

    订购信息

    产品名称产品编号规格价格数量收藏夹

    OX2R 抗体 (OX110)

    sc-53103
    200 µg/ml
    		CNY2422.00

    OX2R 抗体 (OX110) FITC

    sc-53103 FITC
    200 µg/ml
    		CNY2527.00

    OX2R 抗体 (OX110) PE

    sc-53103 PE
    200 µg/ml
    		CNY2625.00

    How can I use this product for IF in mouse slice? I had tested it for 1:100 dilution, while it didn't work.

    Asked by: Cancan
    Thank you for your question. This rat monoclonal antibody, OX2R (OX110): sc-53103, is currently only recommended for use in flow cytometry (FCM). We have not yet tested the antibody for IF in mouse tissue sections. In general, we would recommend using a starting dilution of 1:50 for IF.
    Answered by: Technical Support
    Date published: 2017-07-31

    How can OX2R (OX110): sc-53103 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

    Asked by: TinTin
    In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-53103 PE) or fluoroscein (sc-53103 FITC).
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 4 out of 5 by LM from Produced good indirect FCM data for mouseProduced good indirect FCM data for mouse peripheral blood leukocytes stained with OX2R . -SCBT QC
    Date published: 2013-04-22
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    OX2R 抗体 (OX110) is rated 4.0 out of 5 by 1.
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