Date published: 2025-9-8

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Op18 抗体 (A-4): sc-48362

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说明书
  • Op18抗体(A-4)是小鼠单克隆IgG2b κ, 在12篇文献中引用,规格为200 µg/ml
  • 与氨基酸1-149结合,代表全长Op18,human起源
  • 抗-Op18 抗体 (A-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Op18 and other stathmin family members including stathmin-like protein RB3 and SCG10-like protein
  • 抗Op18抗体(A-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Op18 (A-4): sc-48362免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP 是 Op18 抗体 (A-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Op18 抗体 (A-4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Op18抗体(A-4)是一种小鼠单克隆IgG2b kappa轻链抗体,可通过包括蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)在内的方法,在小鼠、大鼠和人类样本中检测Op18以及其他stathmin家族成员,如stathmin样蛋白RB3和SCG10样蛋白。Op18 (A-4) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。Op18,又称癌蛋白18、丝蛋白酶抑制剂、原蛋白或代谢蛋白,是一种高度保守的、与微管蛋白相关的细胞内磷蛋白,在调节微管动力学方面发挥着关键作用。Op18(A-4)单克隆抗体通过调节微管的稳定性和组织结构发挥作用,而微管对于细胞分裂和细胞内运输等各种细胞过程至关重要。Op18以多种磷酸化形式存在,并表达为两种不同的同工型,其活性受磷酸化事件严格调控。值得注意的是,Op18受抑癌蛋白p53下调,这表明Op18与影响细胞增殖和分化的关键细胞信号通路有关。Op18的过度表达与多种癌症有关,包括乳腺癌和急性白血病的多种亚型,这凸显了Op18作为肿瘤生物标志物和治疗靶标的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Op18 抗体 (A-4) 参考文献:

  1. p53 诱导后,stathmin/Op18 和 FKBP25 基因下调。  |  Ahn, J., et al. 1999. Oncogene. 18: 5954-8. PMID: 10557083

订购信息

产品名称产品编号规格价格数量收藏夹

Op18 抗体 (A-4)

sc-48362
200 µg/ml
$316.00

Op18 (A-4): m-IgG Fc BP-HRP 套装

sc-528530
200 µg Ab; 10 µg BP
$354.00

Op18 (A-4): m-IgGκ BP-HRP 套装

sc-520926
200 µg Ab, 40 µg BP
$354.00

Op18 抗体 (A-4) AC

sc-48362 AC
500 µg/ml, 25% agarose
$416.00

Op18 抗体 (A-4) HRP

sc-48362 HRP
200 µg/ml
$316.00

Op18 抗体 (A-4) FITC

sc-48362 FITC
200 µg/ml
$330.00

Op18 抗体 (A-4) PE

sc-48362 PE
200 µg/ml
$343.00

Op18 抗体 (A-4) Alexa Fluor® 488

sc-48362 AF488
200 µg/ml
$357.00

Op18 抗体 (A-4) Alexa Fluor® 546

sc-48362 AF546
200 µg/ml
$357.00

Op18 抗体 (A-4) Alexa Fluor® 594

sc-48362 AF594
200 µg/ml
$357.00

Op18 抗体 (A-4) Alexa Fluor® 647

sc-48362 AF647
200 µg/ml
$357.00

Op18 抗体 (A-4) Alexa Fluor® 680

sc-48362 AF680
200 µg/ml
$357.00

Op18 抗体 (A-4) Alexa Fluor® 790

sc-48362 AF790
200 µg/ml
$357.00

What is the complete reactivity of this antibody?

Asked by: AbPolly
Thank you for your question. This antibody is recommended for detection of Op18 and other stathmin family members including stathmin-like protein RB3 and SCG10-like protein. For homology and alignments with other specific protein targets, please contact our Technical Service department.
Answered by: Technical Support 15
Date published: 2017-02-07
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Rated 5 out of 5 by from Excellent results with WBGot strong bands of OP18 in Western blot, used at 1:500 dilution
Date published: 2018-01-27
Rated 4 out of 5 by from Good for IFThis Op18 Antibody (A-4) shows strong specific signal in IF staining in primary rat motor neuron.
Date published: 2017-12-04
Rated 4 out of 5 by from Works by IFThis antibody worked decently in cryosectioned and paraformaldehyde fixed human epidermis, but it was a bit weak at a 1:100 dilution.
Date published: 2017-08-31
Rated 1 out of 5 by from Didn't work-Western BlotWe tried a sample of this antibody when we ran out of our regular anti-stathmin antibody that we normally buy from a different company. This antibody didn't work on our lysates (A20). It only gave a small smudge plus a few dark background bands.
Date published: 2017-08-24
Rated 3 out of 5 by from clear bandwork not very well in A549 cells and Hela cells,diluted at 1:1000
Date published: 2017-07-11
Rated 5 out of 5 by from Very popular choice for IHC(P)This mouse monoclonal Op18 antibody, clone (A-4), is a very popular choice for immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, or IHC(P).
Date published: 2017-01-24
Rated 5 out of 5 by from Great immunoperoxidase cytoplasmic stainingGreat immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human lymph node tissue. -SCBT QC
Date published: 2015-05-15
Rated 4 out of 5 by from Nice band detected in WB using KNice band detected in WB using K-562 whole cell lysate. -SCBT QC
Date published: 2015-04-17
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Op18 抗体 (A-4) is rated 3.9 out of 5 by 9.
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