Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

Oct-6 抗体 (A-8): sc-376093

4.5(2)
寫評論提問

说明书
  • Oct-6抗体(A-8)是小鼠单克隆mouse IgG1 κ (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列111-160位于human物种的Oct-6的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的Oct-6 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-376093 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Oct-6 Antibody (A-8) for WB applications. 的首选辅助检测试剂,这些试剂现与Oct-6 Antibody (A-8) 打包提供(请参阅下面的订购信息)。

    快捷链接

    関連項目

    POU同源结构域蛋白是转录调节因子,在不同的发育过程(如细胞分裂、分化、特定细胞类型的特异性和存活)中发挥作用,并参与细胞命运的决定。POU转录因子Oct-6(也称为SCIP和Tst-1)由晚期胚胎周围神经系统的雪旺细胞表达,也由成人的非髓鞘形成雪旺细胞表达。Oct-6在髓鞘前细胞中强烈上调,因为它是髓鞘前细胞及时分化为髓鞘细胞所必需的。Oct-6在髓鞘形成过程中起作用,当髓鞘形成时,它需要适当下调其自身的基因。c-Myc可以与Oct-6的POU结构域协同作用,在哺乳动物中枢神经系统中产生髓鞘疾病。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Oct-6 抗体 (A-8) 参考文献:

    1. 鉴定 OCT6 是一种优先在造血细胞和白血病中表达的新型有机阳离子转运体。  |  Gong, S., et al. 2002. Exp Hematol. 30: 1162-9. PMID: 12384147
    2. Oct-6:一种在胚胎干细胞和发育中的大脑中表达的 POU 转录因子。  |  Suzuki, N., et al. 1990. EMBO J. 9: 3723-32. PMID: 1976514
    3. 八聚体结合因子 6(Oct-6/Pou3f1)由干扰素诱导,有助于dsRNA介导的转录反应。  |  Hofmann, E., et al. 2010. BMC Cell Biol. 11: 61. PMID: 20687925
    4. 对 Oct6 Schwann 细胞增强子的功能解剖揭示了二聚体 Sox10 结合的重要作用。  |  Jagalur, NB., et al. 2011. J Neurosci. 31: 8585-94. PMID: 21653862
    5. SIRT1/OCT6轴失调导致环境压力诱导的神经诱导缺陷  |  Li, G., et al. 2017. Stem Cell Reports. 8: 1270-1286. PMID: 28434941
    6. 糖尿病大鼠许旺细胞和坐骨神经中胰岛素与 OCT-6 转录因子的相关性。  |  Manu, MS., et al. 2018. Genes Dis. 5: 130-136. PMID: 30258942
    7. POU-Domain转录因子Oct-6/POU3F1是细胞对基因毒性应激反应的调控因子。  |  Fionda, C., et al. 2019. Cancers (Basel). 11: PMID: 31212703
    8. Oct-6转录因子可能成为麻风病诊断的生物标志物。  |  Serrano-Coll, H., et al. 2021. Diagn Microbiol Infect Dis. 99: 115232. PMID: 33130505
    9. OCT6 通过 MAPK 和 PI3K 信号调控抑制孔雀石诱导的多能干细胞的分化。  |  Yang, XC., et al. 2022. Zool Res. 43: 911-922. PMID: 36052561
    10. 转录因子 OCT6 通过抑制 Nanog 和激活形成态基因调控网络,促进了幼稚多能状态的消解。  |  Waisman, A., et al. 2024. Sci Rep. 14: 10420. PMID: 38710730

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Oct-6 抗体 (A-8)

    sc-376093
    200 µg/ml
    RMB2377.00

    Oct-6 (A-8): m-IgG Fc BP-HRP 套装

    sc-540510
    200 µg Ab; 10 µg BP
    RMB2662.00

    Oct-6 (A-8): m-IgG1 BP-HRP 套装

    sc-542170
    200 µg Ab; 20 µg BP
    RMB2662.00

    Oct-6 抗体 (A-8) X

    sc-376093 X
    200 µg/0.1 ml
    RMB2377.00

    What is the recommended fixation method for immunofluorescence staining with Oct-6 (A-8): sc-376093 monoclonal antibody?

    Asked by: Trav11
    Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
    Answered by: Technical Support
    Date published: 2017-03-01
    • y_2025, m_8, d_30, h_9CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_376093, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 159ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Works well for IF applicationsWorks well for IF applications, nuclear staining in MeOH fixed HepG2 cells. -SCBT QC
    Date published: 2015-04-10
    Rated 4 out of 5 by from Blowout band at expected molecular weightBlowout band at expected molecular weight in Jurkat and HL-60 whole cell lysates. -SCBT QC
    Date published: 2014-12-13
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_376093, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 13ms
    • REVIEWS, PRODUCT
    Oct-6 抗体 (A-8) is rated 4.5 out of 5 by 2.
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_376093, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 101ms
    • REVIEWS, PRODUCT