Date published: 2025-9-7
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OAS2 Antibody (G-9) - Immunohistochemistry - Image 160000
OAS2 抗体 (G-9): sc-271117. 福尔马林固定, 石蜡包埋的人小肠组织的免疫过氧化物酶染色显示腺细胞的胞浆染色.
OAS2 抗体 (G-9): sc-271117. 福尔马林固定, 石蜡包埋的人小肠组织的免疫过氧化物酶染色显示腺细胞的胞浆染色.

OAS2 抗体 (G-9): sc-271117

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说明书
  • OAS2 抗体 G-9 是小鼠单克隆 IgG2b κ，OAS2抗体, 在10篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于mouse物种的OAS2的C-terminus附近的氨基酸706-735之间
  • OAS2 抗体 (G-9) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 OAS2
  • 抗OAS2抗体（G-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于ChIP的TransCruz试剂(sc-271117 X, 200 µg/0.1 ml)
  • 关于如何获取OAS2 (G-9): sc-271117的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2b BP-HRP 是 OAS2 抗体 (G-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与OAS2 抗体 (G-9) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 OAS 抗体 包括 OAS1, Oas1a, OAS2和OAS3

OAS2抗体（G-9）是一种IgG2b κ小鼠单克隆OAS2抗体，可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人的OAS2蛋白。OAS2抗体（G-9）既可以非偶联的抗OAS2抗体形式存在，也可以多种偶联形式的抗OAS2抗体存在，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。2'-5'-寡腺苷酸合成酶（OAS）家族由四个成员组成：OAS1、OAS2、OAS3和OASL。这些蛋白由干扰素诱导，在双链RNA和镁离子存在下将ATP转化为2'-5'-连接的腺苷酸低聚物。铜离子、铁离子和锌离子强烈抑制OAS酶活性，而锰离子可以取代镁离子作为激活剂。OAS家族在抑制细胞蛋白合成和抵抗病毒感染中发挥着重要作用。OAS2代表OAS家族中的"中型"，包含两个由富含脯氨酸的假定连接区隔开的OAS1同源结构域。它以二聚体的形式发挥功能。OAS2的异常表达模式可能与狼疮患者的感染爆发有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

OAS2 抗体 (G-9) 参考文献:

  1. 二价金属离子对 2'-5' 寡腺苷酸合成酶的抑制作用。  |  Hartmann, R., et al. 2001. FEBS Lett. 507: 54-8. PMID: 11682059
  2. 小鼠 2',5'-醇腺苷酸合成酶基因家族的基因组结构。  |  Kakuta, S., et al. 2002. J Interferon Cytokine Res. 22: 981-93. PMID: 12396720
  3. 2'-5'-oligoadenylate synthetase 泛素样家族的特征。  |  Eskildsen, S., et al. 2003. Nucleic Acids Res. 31: 3166-73. PMID: 12799444
  4. 干扰素治疗慢性丙型肝炎三种不同方案早期阶段的抗病毒作用和病毒动态：每日两次使用干扰素-β治疗与干扰素-α加利巴韦林联合治疗之间的差异。  |  Nakajima, H., et al. 2003. Acta Med Okayama. 57: 217-25. PMID: 14679399
  5. 人类 2'-5' 寡腺苷酸合成酶的三维模型：重建酶组装的新计算方法。  |  Torshin, IY. 2005. Med Sci Monit. 11: BR235-47. PMID: 15990685
  6. 1 型糖尿病与 OAS 基因簇：与剪接多态性或单体型有关？  |  Tessier, MC., et al. 2006. J Med Genet. 43: 129-32. PMID: 16014697
  7. 哺乳动物 2'-5' 寡腺苷酸合成酶基因家族：啮齿目和有齿目同源 Oas1 基因协同进化的证据。  |  Perelygin, AA., et al. 2006. J Mol Evol. 63: 562-76. PMID: 17024523
  8. 2', 5'-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway.  |  Liao, X., et al. 2020. Viruses. 12: PMID: 32276512
  9. 乳腺癌中OAS1/OAS2/OAS3/OASL的预后特征。  |  Zhang, Y. and Yu, C. 2020. BMC Cancer. 20: 575. PMID: 32560641
  10. AT1R自身抗体通过激活AT1R-OAS2促进平滑肌细胞的表型转换。  |  Zhang, X., et al. 2024. Biochem Pharmacol. 219: 115977. PMID: 38092283
  11. Genetic variants of LRRC8C, OAS2, and CCL25 in the T cell exhaustion-related genes are associated with non-small cell lung cancer survival.  |  Lu, G., et al. 2024. Front Immunol. 15: 1455927. PMID: 39416786
  12. 诱导 2.5 OAS 基因表达和活性不足以实现 IFN-gamma 诱导的神经母细胞瘤细胞分化。  |  Corrias, MV., et al. 1995. Int J Cancer. 62: 223-9. PMID: 7622300

订购信息

产品名称产品编号规格价格数量收藏夹

OAS2 抗体 (G-9)

sc-271117
200 µg/ml
RMB2377.00

OAS2 (G-9): m-IgG Fc BP-HRP 套装

sc-525783
200 µg Ab; 10 µg BP
RMB2662.00

OAS2 (G-9): m-IgG2b BP-HRP 套装

sc-549634
200 µg Ab; 10 µg BP
RMB2662.00

OAS2 抗体 (G-9) X

sc-271117 X
200 µg/0.1 ml
RMB2377.00

OAS2 抗体 (G-9) AC

sc-271117 AC
500 µg/ml, 25% agarose
RMB3129.00

OAS2 抗体 (G-9) HRP

sc-271117 HRP
200 µg/ml
RMB2377.00

OAS2 抗体 (G-9) FITC

sc-271117 FITC
200 µg/ml
RMB2482.00

OAS2 抗体 (G-9) PE

sc-271117 PE
200 µg/ml
RMB2580.00

OAS2 抗体 (G-9) Alexa Fluor® 488

sc-271117 AF488
200 µg/ml
RMB2685.00

OAS2 抗体 (G-9) Alexa Fluor® 546

sc-271117 AF546
200 µg/ml
RMB2685.00

OAS2 抗体 (G-9) Alexa Fluor® 594

sc-271117 AF594
200 µg/ml
RMB2685.00

OAS2 抗体 (G-9) Alexa Fluor® 647

sc-271117 AF647
200 µg/ml
RMB2685.00

OAS2 抗体 (G-9) Alexa Fluor® 680

sc-271117 AF680
200 µg/ml
RMB2685.00

OAS2 抗体 (G-9) Alexa Fluor® 790

sc-271117 AF790
200 µg/ml
RMB2685.00

OAS2 (G-9) 中和勝肽

sc-271117 P
100 µg/0.5 ml
RMB511.00

Hi my name is Preeti, I am running western blot for Oas-2 in mouse lung but i am getting so many bands for Oas2. which one i should consider for Oas-2 for mouse lung.

Asked by: Anonymous
Thank you for your question. OAS2 has been reported to run anywhere between 69-82kDa, but it may be glycosylated which may show the protein as even larger. Please contact technical service directly for assistance if you need further assistance with this antibody.
Answered by: Tech Service
Date published: 2019-09-27

What application is the blocking peptide sc-271117 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of OAS2 expression in GA-10 whole cell lysate.
Date published: 2017-01-19
Rated 5 out of 5 by from WBright size band has been detected by this antibody with human samples.
Date published: 2017-01-11
Rated 5 out of 5 by from Worked with transfected lysate by WBWorked with transfected lysate by WB. -SCBT QC
Date published: 2015-06-01
Rated 5 out of 5 by from WB publishable data with human PCWB publishable data with human PC-3 and SK-Mel-37 - SCBT Publication Review
Date published: 2015-05-01
Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human small intestine tissue. -SCBT QC
Date published: 2013-06-09
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OAS2 抗体 (G-9) is rated 5.0 out of 5 by 5.
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