Date published: 2025-10-23

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NumbL 抗体 (H-5): sc-390799

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说明书
  • NumbL抗体(H-5)是小鼠单克隆mouse IgG2a κ (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列331-410位于human物种的NumbL的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的NumbL WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是NumbL Antibody (H-5) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与NumbL Antibody (H-5) 打包提供(请参阅下面的订购信息)。

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    在果蝇中,神经元细胞命运的决定是由NUMB指导的,NUMB是一种信号适配蛋白,具有两个蛋白质-蛋白质相互作用结构域,即一个磷酸酪氨酸结合结构域和一个富含脯氨酸的SH3结合区(PRR)。哺乳动物的NUMB同源物在发育过程中决定细胞命运方面发挥作用,并与多种蛋白质结合,包括Eps15、LNX1和Notch 1。NumbL(NUMB样蛋白),也被称为Numb-R、NBL、CAG3A、CTG3a、NUMBLIKE或TNRC23,是一种由609个氨基酸组成的细胞质蛋白,与NUMB一样,被认为在细胞命运中发挥作用。NumbL在发育中的脑组织中高水平表达,含有一个PID(磷酸酪氨酸相互作用结构域),并在神经元分化中发挥重要作用,可能与Eps15和Notch 1相关。在小鼠中,NumbL基因的缺失与早期胚胎死亡有关,这表明NumbL在早期发育中起着至关重要的作用。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    NumbL 抗体 (H-5)

    sc-390799
    200 µg/ml
    RMB2377.00

    NumbL (H-5): m-IgG Fc BP-HRP 套装

    sc-540855
    200 µg Ab; 10 µg BP
    RMB2662.00

    NumbL (H-5): m-IgG2a BP-HRP 套装

    sc-546966
    200 µg Ab; 10 µg BP
    RMB2662.00

    Hello. We are interested in this anti-NUMBL Ab (sc-390799 for IF studies. May we have a 10ug free aliquot to test? We will not have proper LNX2 KO controls but if we get differences in localization between WT and Mutant mice we will deepen the analyses.

    Asked by: Eduardo
    Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
    Answered by: Tech Service
    Date published: 2019-05-21

    How much sample do you recommend loading on the gel for Western blot detection using NumbL (H-5): sc-390799?

    Asked by: Trav11
    We recommend loading 40–60 µg whole cell lysate, 10–20 µg nuclear extract, 5-10 µg transfected lysate, or 10–20 ng purified protein per lane. A link to our complete Western blotting protocol is provided here for your reference: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced positive Western blot data of NumbLProduced positive Western blot data of NumbL expression in Y79 whole cell lysate. -SCBT QC
    Date published: 2014-10-17
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    NumbL 抗体 (H-5) is rated 5.0 out of 5 by 1.
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