Date published: 2025-9-7
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NK-1R Antibody (D-11) - Western Blotting - Image 144617
NK-1R 抗体 (D-11): sc-365091. WEHI-3 (A), K-562 (B) 和 CCD-1064Sk (C) 全细胞裂解液中 NK-1R 表达的 Western 印迹分析.
NK-1R 抗体 (D-11): sc-365091. WEHI-3 (A), K-562 (B) 和 CCD-1064Sk (C) 全细胞裂解液中 NK-1R 表达的 Western 印迹分析.

NK-1R 抗体 (D-11): sc-365091

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寫評論提問

说明书
  • NK-1R 抗体 D-11 是小鼠单克隆 IgG1 κ，NK-1R抗体, 在14篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列325-407位于human物种的NK-1R的C-terminus附近
  • NK-1R 抗体 (D-11) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 NK-1R; 也和以下物种反应，包括： 和 equine, canine, bovine and porcine
  • 抗NK-1R抗体（D-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取NK-1R (D-11): sc-365091的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 NK-1R 抗体 (D-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与NK-1R 抗体 (D-11) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
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说明书与实验方案
研究信息

関連項目

NK 抗体

NK-1R抗体（D-11）是一种IgG1 κ小鼠单克隆NK-1R抗体（也称为TACR1抗体、NK1R抗体、SPR抗体、Substance-P受体抗体、NK-1受体抗体、TAC1R抗体、NKIR抗体或Neurokinin-1受体抗体），可通过WB、IP、IF、IHC（P）和ELISA检测小鼠、大鼠和人源的NK-1R蛋白。NK-1R抗体（D-11）既可以是非偶联的抗NK-1R抗体形式，也可以是多种偶联形式的抗NK-1R抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。P物质受体，也称为神经激肽1受体的NK-1R，是一类速激肽受体的成员，还包括NK-2受体和NK-3受体。P物质受体与速激肽肽结合，包括P物质、K物质和神经调节素K。NK-1R可能参与伤害性传递、基底神经节功能或焦虑和抑郁。NK-1R高比例表达于位于层1的脊索和脊神经分支神经元。脊髓背角的NK-1R神经元可能在慢性神经性和炎性疼痛中发挥作用。配体诱导的NK-1R内化到早期内体中会耗尽这些细胞表面的受体。这种内化可能参与细胞对P物质的下调反应。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NK-1R 抗体 (D-11) 参考文献:

  1. 新生儿和成人脊髓中 P 物质受体 (NK1) 类免疫反应神经元的分布。  |  Ding, YQ., et al. 1999. Neurosci Lett. 266: 133-6. PMID: 10353345
  2. 大脑中的速激肽 NK1 受体：药理学和假定功能。  |  Saria, A. 1999. Eur J Pharmacol. 375: 51-60. PMID: 10443564
  3. 表达 P 物质受体的脊髓神经元传递慢性痛觉。  |  Nichols, ML., et al. 1999. Science. 286: 1558-61. PMID: 10567262
  4. 人类 P 物质受体的分子克隆, 结构特征和功能表达。  |  Takeda, Y., et al. 1991. Biochem Biophys Res Commun. 179: 1232-40. PMID: 1718267
  5. SP/NK-1R促进胆囊癌细胞的增殖和迁移。  |  Deng, XT., et al. 2019. J Cell Mol Med. 23: 7961-7973. PMID: 30903649
  6. 神经激肽1受体（NK-1R）拮抗剂：治疗多形性胶质母细胞瘤的潜在靶标。  |  Afshari, AR., et al. 2021. Curr Med Chem. 28: 4877-4892. PMID: 33441062
  7. 具有广谱抗癌活性的碳水化合物NK1R拮抗剂。  |  Recio, R., et al. 2021. J Med Chem. 64: 10350-10370. PMID: 34236855
  8. 神经激肽-1受体（NK-1R）拮抗剂作为克服癌症耐药性的新策略。  |  García-Aranda, M., et al. 2022. Cancers (Basel). 14: PMID: 35565383
  9. 通过调节慢性肾脏疾病的炎症反应和细胞命运，靶向NK-1R可减轻肾纤维化。  |  Zhu, E., et al. 2023. Front Immunol. 14: 1142240. PMID: 37033943
  10. 利用NK1R拮抗剂和选择性COX-2抑制剂的协同潜力，同时靶向TNBC细胞和癌干细胞。  |  Singh, MT., et al. 2024. J Drug Target. 32: 258-269. PMID: 38252517
  11. 上皮细胞中表达的 P 物质（NK1）受体的激动剂诱导内化。  |  Garland, AM., et al. 1994. Biochem J. 303 (Pt 1): 177-86. PMID: 7524481
  12. 躯体感觉刺激后脊髓神经元的受体内吞和树突重塑  |  Mantyh, PW., et al. 1995. Science. 268: 1629-32. PMID: 7539937

订购信息

产品名称产品编号规格价格数量收藏夹

NK-1R 抗体 (D-11)

sc-365091
200 µg/ml
RMB2377.00

NK-1R (D-11): m-IgG Fc BP-HRP 套装

sc-527332
200 µg Ab; 10 µg BP
RMB2662.00

NK-1R (D-11): m-IgG1 BP-HRP 套装

sc-532705
200 µg Ab; 20 µg BP
RMB2662.00

NK-1R 抗体 (D-11) AC

sc-365091 AC
500 µg/ml, 25% agarose
RMB3129.00

NK-1R 抗体 (D-11) HRP

sc-365091 HRP
200 µg/ml
RMB2377.00

NK-1R 抗体 (D-11) FITC

sc-365091 FITC
200 µg/ml
RMB2482.00

NK-1R 抗体 (D-11) PE

sc-365091 PE
200 µg/ml
RMB2580.00

NK-1R 抗体 (D-11) Alexa Fluor® 488

sc-365091 AF488
200 µg/ml
RMB2685.00

NK-1R 抗体 (D-11) Alexa Fluor® 546

sc-365091 AF546
200 µg/ml
RMB2685.00

NK-1R 抗体 (D-11) Alexa Fluor® 594

sc-365091 AF594
200 µg/ml
RMB2685.00

NK-1R 抗体 (D-11) Alexa Fluor® 647

sc-365091 AF647
200 µg/ml
RMB2685.00

NK-1R 抗体 (D-11) Alexa Fluor® 680

sc-365091 AF680
200 µg/ml
RMB2685.00

NK-1R 抗体 (D-11) Alexa Fluor® 790

sc-365091 AF790
200 µg/ml
RMB2685.00

It looks one referece posted (PMID: # 30862903 Blass, G.|Klemens, CA.|Brands, MW.|Palygin, O.|Staruschenko, A.| et al. 2019. Sci Rep. 9: 4296) is not appropriate for this antibody. Please provide proper references.

Asked by: sloth
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

Are there any issues with using sc-365091: NK-1R (D-11) mouse monoclonal primary antibody on mouse samples?

Asked by: Professor Griffin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-365091 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Quite goodThe antibody I ordered was mainly used in Western blot, and my specimen was a rat uterus, and the results were good.
Date published: 2017-08-11
Rated 5 out of 5 by from Worked great.We got specific signal for the protein at the right molecular weight.
Date published: 2017-02-13
Rated 5 out of 5 by from Great resultsNK-1R antibody worked well in the mouse samples, It shows hight express in rat spleen tissue.we feel good about the antibody.
Date published: 2017-02-08
Rated 5 out of 5 by from strong signalSuccessfully used in WB applications with mouse brain tissue,use 5% non-fat milk for blocking buffer,dilution 1:600 can got strong band.
Date published: 2017-01-30
Rated 5 out of 5 by from Produced nice Western blot data of NKProduced nice Western blot data of NK-1R expression in WEHI-3, K-562 and CCD-1064Sk whole cell lysates. -SCBT QC
Date published: 2014-01-01
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NK-1R 抗体 (D-11) is rated 5.0 out of 5 by 5.
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