Date published: 2025-9-8

021-6093-6350

SCBT Portrait Logo
Seach Input

Nischarin 抗体 (D-1): sc-374407

5.0(2)
寫評論提問

说明书
  • Nischarin抗体(D-1)是小鼠单克隆IgG1 κ, 在3篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1212-1504位于human物种的Nischarin的C-terminus
  • 推荐用于 mouse, rat 和 human 来源的Nischarin WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Nischarin Antibody (D-1) for WB applications. 的首选辅助检测试剂,这些试剂现与Nischarin Antibody (D-1) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

整合素在细胞的关键功能中扮演着重要角色,包括细胞骨架组织、生长、生存、运动和基因表达调控。Nischarin是一种新型的细胞内蛋白质,它与整合素α5/β1的细胞质结构域结合,并与PAK激酶家族的各种成员相互作用。Nischarin与PAK1的结合抑制了PAK1磷酸化底物的能力。当结合时,这个复合物定位于参与细胞运动的膜皱褶。Nischarin还充当细胞运动中Rac功能的拮抗剂,并改变肌动蛋白丝的组织。这些功能使Nischarin可能在细胞迁移调控中发挥作用。Nischarin是一种主要表达于肾脏和脑部的细胞质蛋白质。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Nischarin 抗体 (D-1) 参考文献:

  1. 咪唑啉-1受体候选物IRAS和nischarin同源物的细胞信号传导。  |  Piletz, JE., et al. 2003. Ann N Y Acad Sci. 1009: 392-9. PMID: 15028618
  2. 整合素结合蛋白Nischarin通过抑制PAK调节细胞迁移。  |  Alahari, SK., et al. 2004. EMBO J. 23: 2777-88. PMID: 15229651
  3. Nischarin抑制LIM激酶,从而调节丝切蛋白磷酸化及细胞侵袭。  |  Ding, Y., et al. 2008. Mol Cell Biol. 28: 3742-56. PMID: 18332102
  4. 转移性乳腺癌中整合素结合蛋白Nischarin的表达。  |  Chen, J., et al. 2015. Mol Med Rep. 12: 77-82. PMID: 25695373
  5. Nischarin的表达与雌激素受体呈负相关,并改变人类乳腺癌的细胞凋亡、迁移和侵袭。  |  Chang, C., et al. 2017. Biochem Biophys Res Commun. 484: 536-542. PMID: 28131840
  6. Nischarin突变雌性小鼠胰岛素抵抗的发展。  |  Dong, S., et al. 2019. Int J Obes (Lond). 43: 1046-1057. PMID: 30546133
  7. 新生大鼠腹侧延髓中拟脲嘧啶1受体候选蛋白nischarin的表达。  |  Nagakura, Y., et al. 2021. Neurosci Lett. 761: 136113. PMID: 34265418
  8. 非肾上腺素能咪唑啉-1受体蛋白nischarin是星形胶质细胞谷氨酸摄取的关键调节剂。  |  Gupta, S., et al. 2022. iScience. 25: 104127. PMID: 35434559
  9. IRAS/Nischarin通过激活小鼠大脑伏隔核中的谷氨酸受体来调节吗啡的奖赏作用。  |  Li, S., et al. 2022. Biomed Pharmacother. 153: 113346. PMID: 36076473
  10. 对人类肿瘤类型中nischarin表达的分析揭示了其环境依赖性,并揭示了其作为肿瘤药物再开发靶标的潜力。  |  Ostojić, M., et al. 2024. PLoS One. 19: e0299685. PMID: 38781180

订购信息

产品名称产品编号规格价格数量收藏夹

Nischarin 抗体 (D-1)

sc-374407
200 µg/ml
RMB2377.00

Nischarin (D-1): m-IgG Fc BP-HRP 套装

sc-540448
200 µg Ab; 10 µg BP
RMB2662.00

Nischarin (D-1): m-IgG1 BP-HRP 套装

sc-542130
200 µg Ab; 20 µg BP
RMB2662.00

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-374407: Nischarin (D-1) mouse monoclonal antibody will work?

Asked by: jenniferc
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
  • y_2025, m_8, d_31, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_374407, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Satisfactory Western Blot data of NischarinSatisfactory Western Blot data of Nischarin expression in PC-12 whole cell lysate. -SCBT QC
Date published: 2015-01-23
Rated 5 out of 5 by from Great Western Blot data of Nischarin expressionGreat Western Blot data of Nischarin expression in non-transfected and human Nischarin transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-11-02
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_374407, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Nischarin 抗体 (D-1) is rated 5.0 out of 5 by 2.
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_374407, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 103ms
  • REVIEWS, PRODUCT