Date published: 2025-9-8

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N-SMase 抗体 (56-7): sc-100593

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说明书
  • N-SMase抗体(56-7)是小鼠单克隆IgG3 κ, 在1篇文献中引用,规格为50 µg/0.5 ml
  • 免疫human物种的重组N-SMase
  • 推荐用于 human 来源的N-SMase WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成N-SMase 抗体 (56-7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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鞘磷脂及其代谢产物现已被证实在一系列细胞信号传导通路中具有第二信使的功能。鞘磷脂细胞信号传导通路的核心是一系列名为鞘磷脂酶的磷脂酶。这些酶分解鞘磷脂,生成神经酰胺和磷酸胆碱。而神经酰胺转而作为一种脂质第二信使,诱发多种细胞调节现象,例如程序性细胞死亡(细胞凋亡)、细胞分化、细胞增殖以及固醇稳态。中性鞘磷脂酶(N-SMase)是一种对Mg2+敏感的酶,可被一系列生理相关且结构多样的分子激活,如肿瘤坏死因子α(TNFα)、氧化型人类低密度脂蛋白(Ox-LDL)以及若干生长因子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

N-SMase 抗体 (56-7) 参考文献:

  1. 中性鞘磷脂酶抑制参与了 N-乙酰半胱氨酸治疗心肌梗死后衰竭心脏大鼠的益处。  |  Adamy, C., et al. 2007. J Mol Cell Cardiol. 43: 344-53. PMID: 17707397
  2. 中性鞘氨醇酶与乳腺癌研究。  |  Hwang, SY., et al. 2015. J Menopausal Med. 21: 24-7. PMID: 26046034
  3. 中性鞘氨醇酶2在T细胞受体信号传导和极性中的作用。  |  Collenburg, L., et al. 2018. Biol Chem. 399: 1147-1155. PMID: 29337691
  4. 中性鞘氨醇酶和酸性鞘氨醇酶的生理功能及治疗应用。  |  Xiang, H., et al. 2021. Biomed Pharmacother. 139: 111610. PMID: 33957567
  5. 抑制中性鞘氨醇酶2会破坏HIV-1包膜的形成,并显著延迟或消除病毒反弹。  |  Yoo, SW., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219543120. PMID: 37406092
  6. HIV-1的成熟需要中性鞘氨醇酶2。  |  Waheed, AA., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219475120. PMID: 37406093
  7. 中性鞘氨醇酶阻断通过综合应激反应增强造血干细胞的适应性。  |  Hurwitz, SN., et al. 2023. Blood. 142: 1708-1723. PMID: 37699202
  8. 中性鞘氨醇酶抑制剂可促进体外和体内的局部和网状变性。  |  Risner, ML., et al. 2023. Cell Commun Signal. 21: 305. PMID: 37904133
  9. 中性鞘氨醇酶2的抑制作用可限制肝脂肪变性及炎症。  |  Al-Rashed, F., et al. 2024. Cells. 13: PMID: 38474427
  10. 中性鞘氨醇酶-2(NSM2)在T细胞中性脂质储存控制中的作用。  |  Schempp, R., et al. 2024. Int J Mol Sci. 25: PMID: 38542220

订购信息

产品名称产品编号规格价格数量收藏夹

N-SMase 抗体 (56-7)

sc-100593
50 µg/0.5 ml
RMB2504.00

Can sc-100593: N-SMase (56-7) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: AbPolly
Thank you for your question. Yes, sc-100593: N-SMase (56-7) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 3 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-31
Rated 3 out of 5 by from Good immunoperoxidase membrane staining inGood immunoperoxidase membrane staining in formalin-fixed, paraffin-embedded human lymph node tissue. -SCBT QC
Date published: 2015-02-26
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N-SMase 抗体 (56-7) is rated 3.0 out of 5 by 2.
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