Date published: 2026-4-28

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Myosin Ic 抗体 (13): sc-136544

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说明书
  • Myosin Ic 抗体 13 是小鼠单克隆 IgG1 κ,Myosin Ic抗体, 在9篇文献中引用,规格为200 µg/ml
  • 针对氨基酸239-360 and 859-971和human起源的Myosin Ic的859-971
  • 推荐用于 mouse, rat, human 和 canine 来源的Myosin Ic WB, IP, IF 和 IHC(P)检测
  • 还可偶联琼脂糖 用于IP; 偶联HRP 用于WB, IHC(P) 和ELISA
  • m-IgG Fc BP-HRP是Myosin Ic Antibody (13) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Myosin Ic Antibody (13) 搭配使用(请参阅下面的订购信息)。
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肌球蛋白Ic抗体(13)是一种IgG1κ小鼠单克隆肌球蛋白Ic抗体(也称为肌球蛋白Ic抗体),可通过WB、IP、IF和IHC检测小鼠、大鼠、人类和犬科动物的肌球蛋白Ic蛋白。肌球蛋白Ic抗体(13)可以以非偶联抗肌球蛋白Ic抗体形式和多种偶联抗肌球蛋白Ic抗体形式提供,包括琼脂糖、HRP。肌动蛋白是一种高度保守的蛋白质,在所有真核细胞中都有表达。肌动蛋白丝可以形成稳定和不稳定的结构,是微绒毛和肌肉细胞收缩装置的重要组成部分。肌钙蛋白通过与Ca2+结合促进肌动蛋白和肌球蛋白之间的相互作用。肌钙蛋白由至少两个亚基组成,在心肌、快骨骼肌和慢骨骼肌中存在差异。肌球蛋白是2条重链(MHC)和4条轻链(MLC)的六聚体,与肌动蛋白相互作用,产生各种细胞运动所需的力,包括细胞分裂、吞噬作用和肌肉收缩。肌球蛋白Ic(MYO1C)也被称为肌球蛋白β。在前庭毛细胞中,肌球蛋白-1c可能对快速适应很重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Myosin Ic 抗体 (13) 参考文献:

  1. 肌球蛋白-1c,毛细胞的适应马达。  |  Gillespie, PG. and Cyr, JL. 2004. Annu Rev Physiol. 66: 521-45. PMID: 14977412
  2. Myo1c 专为内耳的适应反应而设计。  |  Batters, C., et al. 2004. EMBO J. 23: 1433-40. PMID: 15014434
  3. 非常规肌球蛋白Myo1c在受调控的外细胞途径中促进膜融合。  |  Bose, A., et al. 2004. Mol Cell Biol. 24: 5447-58. PMID: 15169906
  4. 表达非常规肌球蛋白Myo1c会改变M1集合管细胞的钠转运。  |  Wagner, MC., et al. 2005. Am J Physiol Cell Physiol. 289: C120-9. PMID: 15716323
  5. 肌球蛋白-I的轴突同工型。  |  Lund, LM., et al. 2005. Biochem Biophys Res Commun. 330: 857-64. PMID: 15809075
  6. 前庭毛细胞的快速适应需要肌球蛋白-1c的活性。  |  Stauffer, EA., et al. 2005. Neuron. 47: 541-53. PMID: 16102537
  7. 肌球蛋白 IC 异构体 A 在小鼠、人类细胞系和小鼠前列腺癌组织中的选择性表达。  |  Ihnatovych, I., et al. 2014. PLoS One. 9: e108609. PMID: 25259793
  8. 肌球蛋白-Ic 和非肌球蛋白对驱动蛋白-1 驱动的运输的启动和终止的控制。  |  McIntosh, BB., et al. 2015. Curr Biol. 25: 523-9. PMID: 25660542
  9. 肌球蛋白 Ic 交叉桥的化学机械调控:从单分子机理推导集合体的弹性特性  |  Berger, F. and Hudspeth, AJ. 2017. PLoS Comput Biol. 13: e1005566. PMID: 28549064
  10. 调节蛋白 14-3-3β 与肌球蛋白-IC 的 IQ 基序结合,与磷酸化无关。  |  Ji, HH. and Ostap, EM. 2020. J Biol Chem. 295: 3749-3756. PMID: 31811090
  11. 膜结合肌球蛋白 IC 驱动滑动肌动蛋白丝绕其纵轴进行手性旋转。  |  Sato, Y., et al. 2023. Sci Rep. 13: 19908. PMID: 37963943
  12. 人类刷状缘肌球蛋白-I和肌球蛋白-Ic在人类肠道和Caco-2BBe细胞中的表达。  |  Skowron, JF., et al. 1998. Cell Motil Cytoskeleton. 41: 308-24. PMID: 9858156

订购信息

产品名称产品编号规格价格数量收藏夹

Myosin Ic 抗体 (13)

sc-136544
200 µg/ml
CNY2422.00

Myosin Ic (13): m-IgG Fc BP-HRP 套装

sc-551918
200 µg Ab; 10 µg BP
CNY2715.00

Myosin Ic 抗体 (13) AC

sc-136544 AC
500 µg/ml, 25% agarose
CNY3189.00

Myosin Ic 抗体 (13) HRP

sc-136544 HRP
200 µg/ml
CNY2422.00

I am using Myosin Ic (13): sc-136544 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Professor Griffin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Specific MYO1C detection by WB and IFThis Myosin Ic antibody (13) showed excellent specificity and a high signal-to-noise ratio. It performed robustly in Immunoblotting (1:800) and Immunofluorescence (1:100) in PFA-fixed HeLa cells, enabling precise localization of MYO1C during C. trachomatis infection. This was critical to define its role in actin cage formation. Highly reliable for cytoskeletal and infection studies.
Date published: 2026-04-21
Rated 5 out of 5 by from EXCELLENT ANTIBODY!This antibody is extraordinarily excellent ! It can be recycled for several times !
Date published: 2017-02-13
Rated 5 out of 5 by from Recommended for the use in IHC(P)Beautiful membrane and cytoplasmic immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue.
Date published: 2017-01-23
Rated 4 out of 5 by from Good Western blot results using KGood Western blot results using K-562 whole cell lysate. -SCBT QC
Date published: 2015-05-13
Rated 5 out of 5 by from Good quality antibody for human paraffin samplesGood quality antibody for human paraffin samples. Specific and sensitive -SCBT QC
Date published: 2015-02-26
Rated 5 out of 5 by from Robust and specific signal by Western blotRobust and specific signal by Western blot in HeLa whole cell lysate -SCBT QC
Date published: 2014-11-28
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Myosin Ic 抗体 (13) is rated 4.8 out of 5 by 6.
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