Date published: 2025-9-7
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MYH10 Antibody (A-5) - Western Blotting - Image 260752
MYH10 抗体 (A-5): sc-376954. IMR-32 全细胞裂解液 (A), 小鼠大脑 (B) 和大鼠大脑 (C) 组织提取物中 MYH10 表达的 Western 印迹分析.
MYH10 抗体 (A-5): sc-376954. IMR-32 全细胞裂解液 (A), 小鼠大脑 (B) 和大鼠大脑 (C) 组织提取物中 MYH10 表达的 Western 印迹分析.

MYH10 抗体 (A-5): sc-376954

4.6(5)
寫評論提問

说明书
  • MYH10抗体(A-5)是小鼠单克隆IgG2a λ, 在4篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的myosin heavy chain 10的N-terminus的氨基酸2-27之间
  • 推荐用于 mouse, rat 和 human 来源的myosin heavy chain 10 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应，包括： 和 equine, canine and bovine
  • m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP)是 MYH10 抗体 (A-5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与MYH10 抗体 (A-5) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGλ BP 偶联产品，请参阅我们的 小鼠 IgG 结合蛋白完整列表。

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基因信息
说明书与实验方案
研究信息

関連項目

此外 Myosin 抗体 包括 MRLC2, MYH, MYH1, MYH10, MYH11, MYH15, MYH2, MYH3, MYH4和MYH6

肌动蛋白是一种高度保守的蛋白质，在所有真核细胞中都有表达。肌动蛋白丝可以形成稳定和不稳定的结构，是微绒毛和肌肉细胞收缩装置的关键组成部分。肌球蛋白是由两条重链（缩写为MYH或MHC）和四条轻链（MLC）组成的六聚体，与肌动蛋白相互作用，产生各种细胞运动所需的力，包括胞质分裂、吞噬作用和肌肉收缩。MYH10也被称为肌球蛋白IIb、肌球蛋白-10、NMMHC-IIB、非肌肉肌球蛋白重链IIb或细胞肌球蛋白重链B型。MYH10参与细胞形状、胞质分裂和特殊功能，如帽化和分泌。它在白细胞和肾脏的肾小球中表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MYH10 抗体 (A-5) 参考文献:

  1. Myh10 的点突变会导致心脏发育和体壁闭合出现重大缺陷。  |  Ma, X. and Adelstein, RS. 2014. Circ Cardiovasc Genet. 7: 257-65. PMID: 24825879
  2. 一例携带新型 MYH10-RET 融合体的晚期婴儿肌纤维瘤病。  |  Rosenzweig, M., et al. 2017. Pediatr Blood Cancer. 64: PMID: 28028925
  3. 在哺乳动物的发育过程中，心外膜功能和冠状血管的形成需要非肌肉肌球蛋白 IIB (Myh10)。  |  Ridge, LA., et al. 2017. PLoS Genet. 13: e1007068. PMID: 29084269
  4. 由 Myh9、Myh10 和 Myh14 编码的非肌肉肌球蛋白 2 蛋白独特地分布在小鼠肾小管节段中。  |  Otterpohl, KL., et al. 2017. Physiol Rep. 5: PMID: 29208685
  5. 肌球蛋白重链 10 (MYH10) 基因沉默通过抑制 Wnt/β-Catenin 通路，减少胶质瘤细胞系 U251、T98G 和 SHG44 的细胞迁移和侵袭。  |  Wang, Y., et al. 2018. Med Sci Monit. 24: 9110-9119. PMID: 30552850
  6. 成年小鼠肾上皮细胞中Myh9和Myh10的条件性失活会导致进行性肾病。  |  Otterpohl, KL., et al. 2020. JCI Insight. 5: PMID: 33001861
  7. 小鼠胚胎植入前发育过程中单亲和双亲母系-同卵双生Myh9和Myh10突变体的多尺度分析  |  Schliffka, MF., et al. 2021. Elife. 10: PMID: 33871354
  8. 产生杂合型（MRli003-A-1）和同源型（MRli003-A-2）MYH10基因敲除人类iPSC株系。  |  Zhang, F., et al. 2021. Stem Cell Res. 57: 102612. PMID: 34864222
  9. LncRNA BlncAD1通过与MYH10、PI3K/Akt信号通路和miR-27a-5p/CDK6轴结合调节牛脂肪生成  |  Li, X., et al. 2024. J Agric Food Chem. 72: 11094-11110. PMID: 38661523
  10. 粗升肢Myh9和Myh10肌球蛋白马达特异性失活导致渐进性肾病，并驱动远端肾小球和集合管的性别特异性细胞适应  |  Otterpohl, KL., et al. 2024. Function (Oxf).. PMID: 39500539

订购信息

产品名称产品编号规格价格数量收藏夹

MYH10 抗体 (A-5)

sc-376954
200 µg/ml
RMB2377.00

MYH10 (A-5): m-IgGλ BP-HRP 套装

sc-523139
200 µg Ab, 40 µg BP
RMB2662.00

MYH10 (A-5) 中和勝肽

sc-376954 P
100 µg/0.5 ml
RMB511.00

Of your Myh10 antibodies, has any of them been tested for cross-reactivity with Myh9? Thanks,

Asked by: Miguel Vicente
Thank you for your question. For this antibody, no cross-reactivity with Myh9 has been found.
Answered by: Tech Support Europe
Date published: 2021-09-10

What application is the blocking peptide sc-376954 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Good antibody for WBTested this antibody in an IP for a nuclear complex that interacts with Myh10. The antibody detected Myh10 very well the first few times I used it but I have seen a slight decrease in sensitivity with storage. Still, it is a very specific antibody because I see a different trend with Myh9 antibody.
Date published: 2016-12-16
Rated 5 out of 5 by from Works well for Western blot with IMRWorks well for Western blot with IMR-32 whole cell lysate and mouse and rat brain tissue extracts. -SCBT QC
Date published: 2015-04-12
Rated 4 out of 5 by from Robust signal strength using this monoclonalRobust signal strength using this monoclonal antibody specifically in IMR-32 whole cell lysate. -SCBT QC
Date published: 2015-02-21
Rated 5 out of 5 by from Great monoclonal antibodyGreat monoclonal antibody! Specific cytoplasmic staining in human cerebellum tissue. -SCBT QC
Date published: 2015-01-16
Rated 5 out of 5 by from Observed strong Western blot positive resultsObserved strong Western blot positive results in SK-N-SH whole cell lysate. -SCBT QC
Date published: 2014-05-26
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MYH10抗体 (A-5) is rated 4.6 out of 5 by 5.
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