Date published: 2026-10-24

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MyD88 Antibody (B-1) - Western Blotting - Image 374237
MyD88 抗体 (B-1): sc-136970. Raji (A), Jurkat (B), SK-BR-3 (C), THP-1 (D) 和 Hep G2 (E) 全细胞裂解液中 MyD88 表达的近红外 western 印迹分析. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 所用检测试剂: m-IgGκ BP-CFL 680: sc-516180.
MyD88 抗体 (B-1): sc-136970. Raji (A), Jurkat (B), SK-BR-3 (C), THP-1 (D) 和 Hep G2 (E) 全细胞裂解液中 MyD88 表达的近红外 western 印迹分析. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 所用检测试剂: m-IgGκ BP-CFL 680: sc-516180.

MyD88 抗体 (B-1): sc-136970

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寫評論提問
说明书
  • MyD88抗体(B-1)是小鼠单克隆IgG2a κ, 在30篇文献中引用，规格为200 µg/ml
  • 免疫human物种的MyD88的氨基酸1-296
  • MyD88 抗体 (B-1) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 MyD88
  • 抗MyD88抗体（B-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是MyD88 Antibody (B-1) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂，这些试剂现与MyD88 Antibody (B-1) 打包提供（请参阅下面的订购信息）。
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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

MyD88抗体（B-1）是一种IgG2a κ小鼠单克隆MyD88抗体，可通过蛋白质印迹、免疫沉淀、免疫荧光、免疫组织化学（石蜡）和酶联免疫吸附试验检测人类来源的MyD88。MyD88抗体（B-1）既有非偶联形式的抗MyD88抗体，也有多种偶联形式的抗MyD88抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。白细胞介素-1（IL-1）诱导的NFκB通路激活是通过IL-1受体和随后IL-1受体相关激酶（IRAK）的磷酸化介导的。髓样分化蛋白MyD88最初被鉴定为在IL-6诱导的生长停滞和终末分化后，在髓样白血病细胞中上调的蛋白。现在已知MyD88作为IRAK与IL-1受体结合的适配蛋白发挥作用。MyD88在功能上与果蝇Toll信号通路中的适配蛋白tube同源，这两种蛋白都是Toll/IL-1R超家族的成员。MyD88含有一个特征性的N端死亡结构域，该结构域对NFκB的激活至关重要，并且与一个相邻的Toll/IL-1R同源结构域（TIR结构域）相邻。这些结构域共同使MyD88能够与IRAK和IL-1受体复合物发生蛋白质-蛋白质相互作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MyD88 抗体 (B-1) 参考文献:

  1. MyD88及其在癌变中的不同作用。  |  Salcedo, R., et al. 2013. Trends Immunol. 34: 379-89. PMID: 23660392
  2. MyD88在结核分枝杆菌感染中的作用。  |  Cervantes, JL. 2017. Med Microbiol Immunol. 206: 187-193. PMID: 28220253
  3. MyD88作为炎症性肺病的治疗靶点。  |  Di Padova, F., et al. 2018. Expert Opin Ther Targets. 22: 401-408. PMID: 29658361
  4. 淋巴恶性肿瘤中的 MYD88 L265P 突变  |  Yu, X., et al. 2018. Cancer Res. 78: 2457-2462. PMID: 29703722
  5. B细胞内在Myd88调节小鼠狼疮的疾病进展  |  Tilstra, JS., et al. 2023. J Exp Med. 220: PMID: 37787782
  6. 靶向 MyD88：特异性抑制剂 ST2825 的治疗机制和潜在应用。  |  Liu, M., et al. 2023. Inflamm Res. 72: 2023-2036. PMID: 37814128
  7. 用MyD88抑制剂阻断MyD88信号传导，通过维持结肠菌群平衡，防止结肠炎相关性结肠癌的发展。  |  Xie, B., et al. 2023. Sci Rep. 13: 22552. PMID: 38110638
  8. MyD88信号通路：在乳腺癌中的作用。  |  Zheng, H., et al. 2024. Front Oncol. 14: 1336696. PMID: 38347830
  9. 肠道菌群通过上皮细胞MyD88调节宿主褪黑激素的产生。  |  Liu, B., et al. 2024. Gut Microbes. 16: 2313769. PMID: 38353638
  10. OTUD5通过增强MyD88的聚合作用和Myddosome的形成来促进炎症免疫反应。  |  Liu, Y., et al. 2024. Cell Death Differ. 31: 753-767. PMID: 38605168

订购信息

产品名称产品编号规格价格数量收藏夹

MyD88 抗体 (B-1)

sc-136970
200 µg/ml
CNY2422.00

MyD88 (B-1): m-IgG Fc BP-HRP 套装

sc-528831
200 µg Ab; 10 µg BP
CNY2715.00

MyD88 (B-1): m-IgGκ BP-HRP 套装

sc-521379
200 µg Ab, 40 µg BP
CNY2715.00

MyD88 抗体 (B-1) AC

sc-136970 AC
500 µg/ml, 25% agarose
CNY3189.00

MyD88 抗体 (B-1) HRP

sc-136970 HRP
200 µg/ml
CNY2422.00

MyD88 抗体 (B-1) FITC

sc-136970 FITC
200 µg/ml
CNY2527.00

MyD88 抗体 (B-1) PE

sc-136970 PE
200 µg/ml
CNY2625.00

MyD88 抗体 (B-1) Alexa Fluor® 488

sc-136970 AF488
200 µg/ml
CNY2738.00

MyD88 抗体 (B-1) Alexa Fluor® 546

sc-136970 AF546
200 µg/ml
CNY2738.00

MyD88 抗体 (B-1) Alexa Fluor® 594

sc-136970 AF594
200 µg/ml
CNY2738.00

MyD88 抗体 (B-1) Alexa Fluor® 647

sc-136970 AF647
200 µg/ml
CNY2738.00

MyD88 抗体 (B-1) Alexa Fluor® 680

sc-136970 AF680
200 µg/ml
CNY2738.00

MyD88 抗体 (B-1) Alexa Fluor® 790

sc-136970 AF790
200 µg/ml
CNY2738.00

I want to know that how many mL of Antibody in one kit?

Asked by: trathaidang
Thank you for your question. sc-136970 MyD88 (B-1) is 200ug in 1ml.
Answered by: BlakeJ
Date published: 2023-12-01

Can I get a free 10 µg sample of MyD88 (B-1): sc-136970?

Asked by: LihC
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: Tech Service
Date published: 2019-02-12

What is the recommended secondary for use with this mouse monoclonal primary antibody?

Asked by: AbPolly
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 13
Date published: 2017-01-20
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Rated 5 out of 5 by Ling from It works as expectedSuccessfully used for MyD88 protein detection in ovine duodenum and works as expected in Western blot and immunohistochemistry.
Date published: 2025-10-26
Rated 5 out of 5 by Yang0310 from It works wellIt is good antibody for western blot in ovine thymus.
Date published: 2021-04-19
Rated 5 out of 5 by trust from the result ofMyD88 antibody (B-1) SAMPLE 10 µg sc-I can get a better staining in duodenum by using MyD88 antibody (B-1) SAMPLE 10 µg sc-136970 SAMPLE
Date published: 2021-01-05
Rated 4 out of 5 by JJaassoonn from Good!I got a clear band with 1:1000 dilution in the human origin primary cells.
Date published: 2018-12-02
Rated 5 out of 5 by erik from WB resultsVery good Western blot data of expression in HCC cell lysates
Date published: 2017-11-05
Rated 4 out of 5 by Ruchi from clear result.this is very nice antibody, it has strong binding. Dilution of 1:1000 works very well for melanoma cells.
Date published: 2017-10-04
Rated 4 out of 5 by nike2017 from 总体还好本研究过程中涉及到了该抗体的使用，该抗体是单克隆抗体，用人的标本进行蛋白印迹实验，需要增加上样量，可以得到清晰的条带。
Date published: 2017-09-28
Rated 5 out of 5 by woojonglee0917 from works great on mouse cell line cell extract. Highlworks great on mouse cell line cell extract. Highly recommended.
Date published: 2017-08-01
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MyD88 抗体 (B-1) is rated 4.8 out of 5 by 16.
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