Date published: 2025-9-8
访问圣克鲁斯动物健康

021-6093-6350

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
MYBPC3 Antibody (G-1) - Western Blotting - Image 355500
MYBPC3 抗体 (G-1): sc-137182. 人胎儿心脏组织提取物中 MYBPC3 表达的 Western 印迹分析.
MYBPC3 抗体 (G-1): sc-137182. 人胎儿心脏组织提取物中 MYBPC3 表达的 Western 印迹分析.

MYBPC3 抗体 (G-1): sc-137182

5.0(4)
寫評論提問

说明书
  • MYBPC3抗体(G-1)是小鼠单克隆IgG1 κ, 在2篇文献中引用，规格为200 µg/ml
  • 针对氨基酸1-120，在MYBPC3的human起源的N-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的MYBPC3 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 MYBPC3 抗体 (G-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MYBPC3 抗体 (G-1) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 MYBPC 抗体 包括 MYBPC3

MYBPC3（肌球蛋白结合蛋白C，心脏）编码厚丝肌球蛋白结合蛋白C的心脏亚型。它存在于脊椎横纹肌A带的横跨桥带（C区）。肾上腺素刺激后，cAMP依赖性蛋白激酶（PKA）对MYBPC3的调节磷酸化可能与心脏收缩的调节有关。MYBPC3结合F-肌动蛋白、MHC和天然细丝，并修饰肌动蛋白激活的肌球蛋白ATP酶的活性。MYBPC3基因突变主要导致蛋白质截断，这是家族性肥厚型心肌病4型（CMH4）的一个原因，这是一种以心室肥大为特征的心脏疾病，通常涉及室间隔，并且通常是不对称的。 MYBPC3基因定位于染色体11p11.2。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MYBPC3 抗体 (G-1) 参考文献:

  1. MYBPC3的交替结局：高发的25 bp缺失突变的后果和治疗意义。  |  Kuster, DW. and Sadayappan, S. 2014. Pflugers Arch. 466: 207-13. PMID: 24327208
  2. 针对新生儿心肌病的 Mybpc3 基因疗法可长期预防小鼠患病。  |  Mearini, G., et al. 2014. Nat Commun. 5: 5515. PMID: 25463264
  3. 重新评估南亚肥厚型心肌病患者的 MYBPC3Δ25bp 非线性缺失。  |  Harper, AR., et al. 2020. Circ Genom Precis Med. 13: e002783. PMID: 32163302
  4. 肥厚型心肌病相关突变 MYBPC3-E334K 不同表型的性别和年龄差异。  |  Yang, QL., et al. 2021. Heart Vessels. 36: 1525-1535. PMID: 33830315
  5. 心脏成纤维细胞缺乏 MYBPC3 会促使其活化并导致纤维化。  |  Zou, X., et al. 2022. Cell Death Dis. 13: 948. PMID: 36357371
  6. 肥厚型心肌病大鼠模型中 MYBPC3 基因突变的同源定向修复。  |  Nie, J., et al. 2023. Gene Ther. 30: 520-527. PMID: 36765144
  7. MYBPC3 单核苷酸多态性相关代谢物的变化与精英运动员适应性心脏功能之间的关系。  |  Riguene, E., et al. 2023. J Cardiovasc Dev Dis. 10: PMID: 37754829
  8. 碱基编辑可有效防止 Mybpc3 突变小鼠早期发生严重心肌病。  |  Wu, S., et al. 2024. Cell Res. 34: 327-330. PMID: 38337022
  9. MYBPC3-c.772G>A突变导致肥厚型心肌病患者诱导干细胞衍生心肌细胞模型中的单倍体缺陷和肌球蛋白循环动力学改变。  |  Steczina, S., et al. 2024. J Mol Cell Cardiol. 191: 27-39. PMID: 38648963
  10. MYBPC3和MYH7介导的肥厚型心肌病的心房颤动基质和导管消融结果  |  Haq, IU., et al. 2024. JACC Clin Electrophysiol. 10: 1380-1391. PMID: 38819352

订购信息

产品名称产品编号规格价格数量收藏夹

MYBPC3 抗体 (G-1)

sc-137182
200 µg/ml
RMB2377.00

MYBPC3 (G-1): m-IgG Fc BP-HRP 套装

sc-539955
200 µg Ab; 10 µg BP
RMB2662.00

MYBPC3 (G-1): m-IgG1 BP-HRP 套装

sc-541811
200 µg Ab; 20 µg BP
RMB2662.00

Why the mouse tissue extract shows in WB has two band with different KD? but the human and rat show only one band in WB?

Asked by: Coraline
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

I am using MYBPC3 (G-1): sc-137182 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Trav11
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_30, h_9CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_137182, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 106ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Good specificity in WB in human transfectedGood specificity in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-25
Rated 5 out of 5 by from Strong band in WB in mouse heart and ratStrong band in WB in mouse heart and rat heart tissue extracts. -SCBT QC
Date published: 2015-01-28
Rated 5 out of 5 by from IHC publishable data with human skeletal muscleIHC publishable data with human skeletal muscle - SCBT Publication Review
Date published: 2015-01-08
Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human heart muscle tissue. -SCBT QC
Date published: 2014-07-26
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_zh_CN, sid_137182, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
MYBPC3 抗体 (G-1) is rated 5.0 out of 5 by 4.
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_zh_CN, sid_137182, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 98ms
  • REVIEWS, PRODUCT
021-6093-6350
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打0086-021-60936350联系我们。
版权所有© 2007-2025 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。